Review Article
Volume 4 Issue 8 - 2020
The Role of Diabetes Mellitus (Both T1D and T2D) in the Atherosclerosis Development-A Systematic Review with Part of Inflammation along with Altered Glucose and Lipid Metabolism for Forming Therapeutic Approaches
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: June 15, 2020; Published: July 30, 2020




Abstract

Earlier we had reviewed the role of micro RNA’s in obesity as well as diabetes mellitus and importance of treating both together with the term diabesity coined along with the role of various transcription factors in lipid metabolism. Further we had evaluated the role of developing drugs for brown adipose tissue thermogenesis (BAT) along with mirabegron in obesity as well as macrophage polarization in Non-alcoholic Fatty Liver Disease (NAFLD) along with various transcription factors in macrophage polarization, besides reviewing the role of macrophage polarization in tackling obesity as well as diabetes mellitus [91-96]. Here we have further tried to summarize the correlation among diabetes mellitus as well as atherosclerosis. Diabetes Mellitus is a well known disorder of the carbohydrate metabolism occurring secondary to defects in insulin liberation, insulin action or both. Atherosclerosis forms secondary to a multiple steps or events that finally culminates in cardiovascular disease (CVD) that is associated with great morbidity as well as mortality. Here we conducted a systematic review to find the correlation among diabetes mellitus as well as atherosclerosis utilizing the pubmed search engine with the MeSH terms like DM; atherosclerosis; Obesity; NAFLD; microRNA; inflammation; macrophage polarization; epigenetics; therapy. We found a total of 26,137 articles out of which we selected 97 articles for this review. It was seen that both type 1 (T1D) as well as type2 diabetes (T2D) can stimulate atherosclerosis formation or increased rate of propagation. Escalated glucose amounts, dyslipidaemia as well as other metabolic derangements have a close role in the etiopathogenesis of atherosclerosis at every step of atherogenic event. Chronic inflammation is believed to be a crucial factor in atherosclerosis formation, being present right from the initiation of the pathology. It might be thought to be a connection among atherosclerosis as well as diabetes mellitus. Inspite of the insight efficacious inflammatory treatments that would halt atherosclerosis generation or decrease further propagation have not been generated. Here we have tried to comprehensively summarize the various aetiopathogenetic pathways including roles of micro RNA as well as epigenetic events, as well as oxidative stress, changed PKC signaling, roles of various transcription factors to help form some effective anti-inflammatory therapies.

Keywords: Diabetes Mellitus; Atherosclerosis; Chronic Inflammation; Micro RNA; Epigenetic Events; Transcription Factors; PKC Signaling; Oxidative Stress

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Citation: Kulvinder Kochar Kaur., et al. “The Role of Diabetes Mellitus (Both T1D and T2D) in the Atherosclerosis Development-A Systematic Review with Part of Inflammation along with Altered Glucose and Lipid Metabolism for Forming Therapeutic Approaches". EC Diabetes and Metabolic Research 4.8 (2020): 27-43.

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