Research Article
Volume 4 Issue 6 - 2020
Effectiveness of Dipeptidyl Peptidase 4 Inhibitors as Monotherapy and Combination Therapy in Control of Hyperglycemia in Diabetic Patients - An Observational Study Protocol
Saroj Kumar Prusty1, Debmalya Sanyal2* and Sauren Panja3
1Senior Resident, Department of Medicine, NH-RTIICS, Kolkata, India
2Department of Endocrinology, NH-RTIICS and KPC Medical College, Kolkata, India
3Head, Department of Medicine, NH-RTIICS, Kolkata, India
*Corresponding Author: Debmalya Sanyal, Department of Endocrinology, NH-RTIICS and KPC Medical College, Kolkata, India.
Received: April 18, 2020; Published: May 27, 2020


The epidemic of type 2 diabetes mellitus worldwide continues without any reduction in intensity. Despite a number of existing therapies, treatment goals are seldom fully achieved. While Insulin resistance and beta cell failure remain important in the pathogenesis of this condition, the role of incretin hormones in glucose homeostasis are becoming more evident. Gliptins inhibit the enzyme dipeptidyl peptidase-4 which degrades incretin hormones by which these drugs control hyperglycemia. This observational study will focus on patients coming to outdoor in medicine and endocrine department. Main emphasis will be early and effective control of hyperglycemia by implementing Gliptins as monotherapy or as combination therapy with metformin. Outcomes will be observed through 3 monthly follow up as per our hospital protocol for diabetic patients by measuring fasting blood sugar (FBS), postprandial blood sugar (PPBS) and glycosylated hemoglobin (HbA1c) level for a period of 9 months. The major goal would be to achieve FBS of less than 130 mg/dl, PPBS of less than 180 mg/dl and a HbA1c of less than 7% in shortest timeline. Emphasis will be given for patients with renal and hepatic impairment while choosing a gliptin by checking serum creatinine, estimated glomerular filtration rate, urine albumin creatinine ratio and serum liver function test. All patients during this study period will be requested and encouraged to do home glucose monitoring.

Keywords: Fasting Blood Sugar (FBS); Postprandial Blood Sugar (PPBS); Glycosylated Hemoglobin (HbA1c)


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Citation: Debmalya Sanyal., et al. “Effectiveness of Dipeptidyl Peptidase 4 Inhibitors as Monotherapy and Combination Therapy in Control of Hyperglycemia in Diabetic Patients - An Observational Study Protocol". EC Nutrition 4.6 (2020): 21-26.

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