Research Article
Volume 4 Issue 6 - 2020
Oral Glucose Tolerance Tests (OGTT) with Alpinia malaccensis Aerial Parts and Rhizome Extracts
Rashed Reza, M M Sultan Mahmud, Md Sohrab Hosen and Mohammed Rahmatullah*
Department of Pharmacy, University of Development Alternative, Lalmatia, Dhaka, Bangladesh
*Corresponding Author: Mohammed Rahmatullah, Professor, Dean, Faculty of Life Sciences, University of Development Alternative, Lalmatia, Dhaka, Bangladesh..
Received:May 11, 2020; Published: May 27, 2020


Diabetes is a metabolic disorder affecting glucose metabolism and homeostasis within the body. In recent years, diabetes has been affecting both young and old, and the number of diabetic and pre-diabetic people have risen to alarming proportions throughout the world. The disease, characterized by high blood glucose levels, rapidly leads to other serious disorders affecting the eyes, kidneys, heart, and brain. Allopathic and traditional medicines can treat only the symptoms but cannot totally cure the disease. Scientists have focused their attention on the plant kingdom in efforts to discover better and more affordable allopathic drugs. Oral glucose tolerance test (OGTT) is one of the ways in which the anti-hyperglycemic efficacy of a drug or formulation can be tested rapidly. We report here that in OGTT, methanol extract of both aerial parts and rhizomes of a Zingiberaceae family plant, Alpinia malaccensis showed promising anti-hyperglycemic efficacy comparable to that of a standard drug, glibenclamide. 

Keywords: Diabetes Mellitus; Alpinia malaccensis; Zingiberaceae; OGTT


  1. World Health Organization (WHO). “Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia”. Report of a World Health Organization/International Diabetes Federation Consultation (2006).
  2. American Diabetes Association (ADA). “Economic costs of diabetes in the US in 2017”. Diabetes Care (2018).
  3. Bnouham M., et al. “Medicinal plants with potential antidiabetic activity – A review of ten years of herbal medicine research”. International Journal of Diabetes and Metabolism 14 (2006): 1-25.
  4. Alarcon-Aguilara FJ., et al. “Study of the anti-hyperglycemic effect of plants used as antidiabetics”. Journal of Ethnopharmacology2 (1998): 101-110.
  5. Sirat HM., et al. “Chemical compositions of the rhizome oils of two Alpinia species of Malaysia”. Natural Product Research10 (2011): 982-986.
  6. Juwitaningsih T., et al. “Two Pyrones with Antibacterial Activities from Alpinia malaccensis”. Natural Product Communications9 (2016): 1297-1298.
  7. Somarathna T., et al. “Antimicrobial activity and phytochemical screening of Alpinia malaccensis (Ran-kiriya) against food-borne bacteria”. Journal of Applied Microbiology5 (2018):1276-1285.
  8. Akhani SP., et al. “Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats”. Journal of Pharmacy and Pharmacology1 (2004): 101-105.
  9. Wei CK., et al. “6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice”. International Journal of Molecular Sciences1 (2017): E168.
  10. Wickenberg J., et al. “Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects”. Nutrition Journal 9 (2010): 43.
  11. Xie Y., et al. “Alpinia oxyphylla Extract Prevents Diabetes in Mice by Modulating Gut Microbiota”. Journal of Diabetes Research 2018 (2018): 4230590.
  12. Joy KL and Kuttan RJ. “Anti-diabetic activity of Picrorrhiza kurroa extract”. Journal of Ethnopharmacology 2 (1999): 143-148.
  13. Jannat K., et al. “Improved oral glucose tolerance with ripe fruit peels of Musa seminifera Lour”. Archives of Natural and Medicinal Chemistry (2018): ANMC-113.
  14. Lopa AF., et al. “Improved oral glucose tolerance with methanol extract of Musa textilis Nee and synergistic action with glibenclamide”. World Journal of Pharmaceutical Research 17 (2018): 204-210.
  15. Rahmatullah M., et al. “Antihyperglycemic and antinociceptive activity evaluation of ‘khoyer’ prepared from boiling the wood of Acacia catechu in water”. African Journal of Traditional, Complementary and Alternative Medicines4 (2013): 1-5.
  16. Agada R., et al. “In vitro and In vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes”. Heliyon3 (2020): e03618.
  17. Etsassala NGER., et al. “Review: Abietane Diterpenes as Potential Candidates for the Management of Type 2 Diabetes”. Current Pharmaceutical Design (2020).
Citation: Mohammed Rahmatullah., et al. “Oral Glucose Tolerance Tests (OGTT) with Alpinia malaccensis Aerial Parts and Rhizome Extracts". EC Nutrition 4.6 (2020): 15-20.

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