Research Protocol
Volume 4 Issue 6 - 2020
Tirzepatide: Summary of the Emerging Data on the Novel GLP-1/GIP Dual Agonist
Jessica Reid1,2, Khyati Rana1, Stephanie Niman1 and Rebecca F Goldfaden1*
1East Coast Institute for Research, Jacksonville, FL, USA
2University of Florida College of Pharmacy, Jacksonville, FL, USA
*Corresponding Author: Rebecca F Goldfaden, East Coast Institute for Research, Jacksonville, FL, USA.
Received: March 12, 2020; Published: May 09, 2020




Abstract

Introduction

The landscape for diabetes treatment is continuously evolving and the demand for medications that simultaneously manages multiple comorbidities, such as cardiovascular (CV) disease (CVD) and obesity, has become the mainstay in diabetes research. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor (GLP-R) agonists (GLP-1RAs) have demonstrated additional benefits for patients with type 2 diabetes mellitus (T2DM), such as reducing body weight (BW), the risk of CV events, death in patients with established CVD, the risk of hospitalization for heart failure (HHF), and/or the risk of major adverse CV events (MACE) in patients with established CVD [1,2]. To meet this growing need for medications that may concurrently manage comorbid conditions associated with T2DM, new molecules are currently being developed and studied. One molecule, tirzepatide, a novel agent in the GLP-1R/glucosedependent insulinotropic polypeptide (GIP) dual agonist class is currently under investigation by Eli Lilly and Company in subjects with T2DM, overweight or obese with weight-related co-morbidities, impaired liver function, and/or an increased CV risk.

References

  1. Rabizadeh S., et al. “Cardiovascular and Renal Benefits of SGLT2 Inhibitors: A Narrative Review”. International Journal of Endocrinology and Metabolism 2 (2019): e84353.
  2. Tran KL., et al. “Overview of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Patients with Type 2 Diabetes”. American Health and Drug Benefits 4 (2017): 178-188.
  3. Gupta K and Raja A. “Physiology, Gastric Inhibitory Peptide”. In StatPearls. StatPearls Publishing (2019).
  4. Coskun T., et al. “LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept”. Molecular Metabolism 18 (2018): 3-14.
  5. Frias JP., et al. “Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial”. The Lancet10160 (2018): 2180-2193.
  6. A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone (SURPASS-1). ClinicalTrials.gov (2020).
  7. A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes (SURPASS-2). ClinicalTrials.gov (2020).
  8. A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes (SURPASS-3). ClinicalTrials.gov (2020).
  9. A Study of Tirzepatide (LY3298176) Versus Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine With or Without Metformin (SURPASS-5). ClinicalTrials.gov (2020).
  10. A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo). ClinicalTrials.gov (2020).
  11. A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT). ClinicalTrials.gov (2020).
  12. A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight (SURMOUNT-1). ClinicalTrials.gov (2020).
  13. A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) (SYNERGY-NASH). ClinicalTrials.gov (2020).
Citation: Rebecca F Goldfaden., et al. “Tirzepatide: Summary of the Emerging Data on the Novel GLP-1/GIP Dual Agonist". EC Nutrition 4.6 (2020): 12-14.

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