Abstract

Present study was aimed to evaluate the anti-diabetic efficacy of Azadirachta indica in Alloxan monohydrate induced albino rats. Oral administration of fresh Azadirachta indica leaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Azadirachta indica leaves. It is amply revealed that fresh Azadirachta indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Azadirachta indica leaves to be almost similar effect like insulin treatment in alloxan monohydrate administered animal model. From the present investigation it appeared that Azadirachta indica leaves might have some ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans located in the pancreas. Once they bind to the Sulphonyl urea receptors, the K⁺ -ATP channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated.

Keywords: Blood Glucose; Insulin; Azadirachta indica; Leaves; Diabetes

References

1. Hung THW., et al. “Anti-diabetic action of Punica granatum flower extract: Activation of PPAR-Y and identification of an active component”. Toxicology and Applied Pharmacology 207.2 (2005): 160-169.
2. Sarvanan G and Leelavinothan P. “Effect of Syzygium cumini bark on blood glucose, plasma glucose and C-peptide in steptozotocin Induced diabetic rats”. International Journal of Endocrinology and Metabolism 4 (2006): 96-105.
3. Satyanarayan K., et al. “Molecular approach to identify anti-diabetic potential of Azadirachta indica”. Journal of Ayurveda and Integrative Medicine 6.3 (2015): 165-175.
4. Lenzen S. “The mechanism of Alloxan and steptozotocin induced diabetes”. Diabetologia 51 (2008): 216-226.
5. Shailey S and Basir SF. “Strengthening of anti-oxidant defense by Azadirachta indica in alloxan diabetic rat tissue”. Journal of Ayurveda and Integrative Medicine 3.3 (2012): 130-135.
6. Saleem T., et al. “Comparison of hypoglycemic Effects of Azadirachta indica Seeds and leaves on Alloxan Induced Diabetes in male Albino rats”. PJMS 12.2 (2018): 753-756.