Review Article
Volume 4 Issue 3 - 2016
The Role of Orthodontic Tooth Movement during Mechanical Force in the Molecule and the Cell
Majid Salman Al-Mohaidaly*
1Department of Dental Sciences, King Saud University, Saudi Arabia
*Corresponding Author: Majid Salman Al-Mohaidaly, Department of Dental Sciences, King Saud University, Saudi Arabia.
Received: April 21, 2016; Published: May 09, 2016
Citation: Majid Salman Al-Mohaidaly. “The Role of Orthodontic Tooth Movement during Mechanical Force in the Molecule and the Cell”. EC Dental Science 4.3 (2016): 803-808.
Abstract
Application of mechanical force on abnormally positionedtooth, cause changes in tooth location and transmitted to the bonein the periodontal ligament (PDL) produce orthodontic toothmovement. This force application is further way that remodelingin the area occurs. In order to develop biological strategies forenhancing this movement of teeth in bone, the underlyingmechanisms of bone resorption and apposition should beunderstood in detail. Analysis of gingival crevicular fluid (GCF)may be a good means of examining the ongoing molecular andcellular process associated with gingival and bone turnover duringorthodontic tooth movement. If it could be possible to biologicallymonitor and predict the outcome of orthodontic force, then theappliance management could be based on dividual tissue responseand the effectiveness of the treatment could be improved andunderstanding their biology is critical in finding ways to modifybone biology to move teeth faster. The present article reviewed ashort introduction to some mayors advanced mechanical force inmolecular and cellular biology during orthodontic tooth movement.
Keywords: Molecule; Cell; Mechanical force; Orthodontic tooth movement; Molecular biology
Introduction
In clinical orthodontic treatment requires application of force system to individual teeth or groups of teeth, which result in cellular response with periodontal ligament (PDL) and alveolar bone remodeling. The force applied must be off sufficient magnitude and duration to exceed the normal physiologic threshold associated with daily oral function. Excessive force levels will result in area of tissue necrosis with delayed tooth movement and increased risk of root resorption.
The PDL, the soft tissue matrix that joins the dental root to the alveolar bone, is composed of an intricate network of blood vessel and nerve ending, the principal cellular components of which are fibroblast and progenitor cells [1]. Although orthodontic tooth movement is achieved in large segment of population, the optimum force level has not been defined. The optimum force for tooth movement depends on individual root geometry as well as biologic characteristics of surrounding tissue including bone density, periodontal thickness, and dynamics of gingival crevicular fluid (GCF) which has three sources: cellular, vascular, and interstitial [2,3,19]. The current concept of optimal force is basedon the hypothesis that a force of a certain magnitude and temporal characteristics continuous, intermittent, constant and declining would be capable of producing a maximum rate of tooth movement without tissue damage and with maximum patient comfort. The optimal force for tooth movement may differ for each individual patient. Orthodontic appliance is generally adjusted or activated about once per month. Within several days after the appliances is adjusted and sustained force is applied to the teeth, some patients complain of senses of in congruity of teeth. It has been reported that such un-usual sensations are diminished after one or two weeks [4]. It has beenan important matter of concern to examine the effect of orthodontic force toward the periodontal tissue, especially, cellular and molecular during tooth movement.
Tooth, Periodontal Ligament and AlveolarBone
The teeth are both secured and suspended within their bony alveolar sockets by a fibrovascular PDL. The PDL consist of cellularcomponents and intercellular components, which fillup the space between the cells. Intercellular components i.e., extra cellular matrix (ECM), are mainly composed of fibrous elements and ground substance [5]. The mayor fibrous elements are collagen fibers type I and type III, which play arole in resisting tensional force and holding teeth in the alveolar socket [6]. The mayor components of the ground substance of the PDL are proteoglycans (core protein + long chain glycosaminoglycans) and glycoproteins. There areconsidered to contribute to viscoelastcity and are necessary in the process of remodeling the PDL.
It is thought that proteoglycans production and distribution change in response to mechanical stress on tissue [6,7]. Cells of the PDL include eosteoblast, osteoclast, fibroblasts, epithelial cell, rest of malassez, macrophage, undifferentiated mesenchymal cell and cementoblasts. Fibroblasts are the principal cells of PDL and are rich in bone alkaline phosphatase activity and osteokalsin. As this enzyme is a requisite for phosphate metabolism in the mineralization ofbone and cementum formation, the PDL fibroblasts are thought to play a role in alveolar bone metabolism [8,12].

Figure 1: Tooth, Periodontal Ligament and Alveolar Bone.

The purpose of an orthodontic appliance is to apply a mechanical force directly to a tooth with the force vector aimed in the intended pathor direction of tooth movement.
Many devices have been used over the years, with varying degrees of success, but all rest upon the same principle that if a sufficient force is applied directly to a tooth, the surrounding PDL and alveolar bone will continue to remodel and adapt until such time that the force is withdrawn either by removal of the appliance or once the tooth moved a sufficient distance such that the original force stored in the wire or spring of the appliance has dissipated.
When the force (F) is applied to the tooth, the associated fibrous and cellular components of the PDL have some capacity to distort as animmediate response. The simplest model is a single rooted tooth like a mandibular canine. The PDL on the side which the force is directed towards will become compressed. This is called as ‘Pressure side’. The PDL on the side which the force is directed away from will become elongated. This is called as ‘Tension side’. This model and the concepts of pressure side and tension side should be kept well in mind as establish a natural conceptual division between the two simultaneous processes which seem necessary in order for teeth to move.
Orthodontic forces produce a distortion ofthe PDL matrix resulting in an alteration incellular shape and cytoskeletal configuration and neuropeptide release from afferent nerve endings. At the biomolecular level, these forces may inducethe release of prostaglandins, growth factors and cytokines [9,10].
Histochemical, immunohistochemistry (IHC) on animals and biochemical studies on human beings support this conclusion. Finally orthodontic forces appear to generate cytokines that effect the formation and resorption of bone.

Figure 2: Tooth, Periodontal Ligament and Alveolar Bone.

One such cytokine, tumor necrosis factors alpha (TNF), is of particular importance since has been shown to be an early modulator of bone resorption and is detectable in the human GCF.
Deposition of new osteoid on the tension side began after 3 days of treatment, area of active osteoblastic resorption with multinucleated osteoclast in their lacunae were found in the pressure side after 4 days of treatment, marker gene expression for osteoblastic differentiation includes: alkaline phosphatase, osteocalcin, andbone sialoprotein all detected by IHC.
Proliferation and recruitment of osteoblastprecursors is an important step in osteogenesison periosteal surfaces, and increase in thenumber of osteoblasts in the area of otherwiseintense bone matrix synthesis suggests that, during bone formation, proliferation of cell hasa smaller role compared to the marked increase in differentiation individual cell [11,12].
Biology of Bone Remodeling and Root Resorption
Due to the low level of forces applied throughout the treatment, the microcirculation atand around the root surface is not compromised.
Two biological phenomena need to be described, one is the alveolar bone remodeling and the other is the integrity of the root structure. In terms of remodeling, a modified type of the alveolar bone resorption is observed. In the traditionally ligated system, where force levels applied and necessary for the tooth movement were in the range of several hundred grams of force, the orthodontic movement was typically described in three phases :- (1) The initial movement due to the PDL compression. (2) The hyalinization period within the PDL with very little or no tooth movement. (3) The tooth movement caused through the process of undermining resorption and largely mediated by the presence of oxygen, brought about by reopening of the capillary network [4,13].
Ideally, the clinician want to eliminate the second phase [shown in red], because it is not a biologically positive or clinically advantageous stage. Instead, one would want to move the tooth in an uninterrupted fashion, where the line representing the tooth movement would be continually advancing in an upward direction with the positive slope and without any significant plateaus or interruptions of that trend. This would additionally suggest the presence of predominantly the desired, frontal bone resorption. With the application of low, continuous forces the tooth movement can appear to be uninterrupted and quite different from that shown on the diagram. It is nearly continuous.
More precisely it fluctuated in cycles of approximately two days. This process is characterized primarily by the frontal resorptionon the pressure side of the root, where the oxygen supply is not seriously compromised, thus allowing osteoblastic activity adjacent to the PDL. At the same time, the tension side is preparing for and then within a few days starts laying down, the new osteomaterial. With this synchronous bone formation and resorption, a new or remodeled alveolar socket is formed, contributing to the apparent fluid motion of fluid mechanics of the tooth movement. The root structure responds in a different fashion, because the root resorption is viewed by most as a negative and undesirable sequel of orthodontic treatment. Among various factors possibly responsible for the root resorption, the ones often listened as the mostlikely are force level and duration. The light, continuous forces typically cause neither pain for the patient nor root resorption. Also, because of the shorter duration of active treatments within teractive self-ligation, forces are applied for a shorter time, further reducing the likelihood of the root resorption [14-17,21].

Figure 3: These stages can be diagrammatically shown in this fashion.

Discussion
The tooth supporting tissue is constantly remodeled under normal conditions with physiological tooth migration. With orthodontic intervention prolonged pressure on the teeth result in enhanced remodeling of periodontal structures, including supracrestals gingival and PDL fibers, as well as alveolar bone. Study of orthodontically induced reactions in the human PDL has been limited. Knowledge of historical responses in the supporting structures of teeth during orthodontic tooth movement is mainly based on animal studies. It has been suggested that the initial phase of orthodontic tooth movement involves many inflammatory-like reactions within the periodontal tissues, characterized by vascular changes and migration of leukocytes out of PDL capillaries [17,18,21]. The remodeling involves differentiation of resident PDL cells into osteoblasts and fibroblasts [1,4,6]. Osteoblasts control both the resorptive and formative phases of the bone remodeling cycle by regulating osteoclasts recruitment and activity.
In addition, osteoblasts produce collagenases, which degrade non-mineralized osteoid covering the resting bone surface and thus enable the osteoclasts to gain access to the mineralized tissue. Prostaglandin (PG) functions as a mediator of thebone resorption induced by experimental tooth movement [8-10,12].
On the pressure side, osteoclasts attract thealveolar bone from the PDL space in the process of direct resorption, allowing rapid tooth movement. On the tension side, new bone is deposited by the osteoblasts until the width of the PDL space has returned to its normal limits.
Over compression in limited areas of the PDL frequently totally occludes blood flow, causing cell death and the development of a cell-free necrotic area. In light microscopy, the tissue reveals a glass like appearance termed hyalinization. When hyalinization occurs, osteoclasts differentiate from the cells within the adjacent bone-marrow spaces to start undermining resorption from the underside of the laminadura. This undermining resorption results in an inevitable delay in tooth movement and may increase root resorption [15,21,22].
GCF is a complex mixture of substances derived from serum, host inflammatory cells, structural cells of the periodontium and oral bacteria. GCF originates from the vessels of the gingival plexus of blood vessels and flows through the external basement membrane and the junctional epithelium to reach the gingival sulcus. GCF can be isolated from health sulcus, although only in small amounts. In the healthy periodontium, GCF represents the transudate of gingival tissue interstitial fluid produced by anosmotic gradient. The volume of GCF increases during periodontal inflammation, primarily due to an increase in the permeability of the vessels underlying the Junctional and vascular epithelium and also due to basement membrane changes.
In addition, the enlarged intercellular spaces of the junctional epithelium act as a reservoir for GCF. Atthe same time, its composition starts to resemble that of an inflammatory exudates [2,3,19].
The collection and analysis of GCF haveprovided a non-invasive and site-specific means to assess the biochemical status of the marginal periodontium. GCF composition is well documented as reflecting also the metabolic state of the deep-seated tissues of the periodontium, e.g., alveolar bone turnover [13,14]. A considerable number of bacteria and host derived products found in the GCF have been associated with the initiation and progression of periodontal disease. Biochemical analysis of GCF shows promise as an effective means forearly detection of periodontal disease. In order to monitor non-invasively the expression of biologically active substances in humans, changes have been studied in the composition of GCF, elevation and partial activation of multiple species of polymorph nuclear leukocyte (PMN) and fibroblast-type MMP reflect periodontal remodeling during orthodontic tooth movement [18,20,21].
Conclusion
As a conclusion, mechanical force is very important in tooth movement especially in the Orthodontic field of Dentistry. Its importance concerning the mechanism of resorption and remodeling effects the movement and arrangement of teeth in the mouth. The use of the (GCF) gingival crevicular fluid as a marker for the ongoing molecular and cellular process associated with the gingival and bone turnover during orthodontic tooth movement is useful and gives important information for that. Further studies should be done on this area to find other findings which will be of great significance in the future for orthodontic tooth movement.
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  4. Pollanen MT., et al. “Structure and Function of the Tooth-Epithelial Interface in Health and Disease”. Journal of Periodontology 31 (2000): 12-31.
  5. Kaneko S., et al. “Occlusal Hypo function Causes Changes in the Proteoglycan Content in the Rat Periodontal Ligament”. Journal of Periodontal Research 36.1 (2001): 9-17.
  6. Beertsen W., et al. “On the role of MT1-MMP, A Matrix Metalloproteinase Essential to Collagen Remodeling in Murine Molar Eruption and Root Growth”. European Journal of Oral Sciences 110.6 (2002): 445-451.
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Copyright: © 2016 Majid Salman Al-Mohaidaly. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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