Research Article
Volume 19 Issue 1 - 2020
Control of Somatostatin Receptor 2 (SSTR2) by Proinflammatory, Microbial and Obesity-Associated Signals in Gingival Crevicular Fluid (GCF), Role of Visfatin and Other Adipokines in Obesity with Periodontitis, Besides Diurnal Rhythms-A Systemic Review to Update the Association of Oral Health with Obesity
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: November 01, 2019; Published: December 05, 2019




Abstract

With the obesity epidemic getting out of control-simultaneous increase in comorbidities is rising as well like type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS) and increased chances of cardiovascular mortality. Hence need of the hour is to control the related causes associated with aetiopathogenesis. Earlier we have emphasized on the role of oral health in obesity. Here we update the information by showing a correlation of presence of somatostatin (SST) in gingival tissues and crevicular fluid (GCF) and how SSTR2 (SST receptor 2) is regulated by proinflammatory, microbial and obesity associated signals in periodontal cells and tissues. With the antiproliferative, antiangiogenic and antiapoptotic actions of SST, SSTR2 might be playing an important role in the aetiopathogenesis of periodontitis. Further we have emphasized on the role of visfatin in aetiopathogesis of obesity and periodontitis besides other cytokines. Role of circadian rhythms and poor lifestyle habits might be responsible especially in children for higher incidence of obesity and periodontitis. Further importance of losing weight emphasizes on how adiponectin improves while tumor necrosis alpha (TNF-α) falls in GCF and helps in curing periodontitis as well. Use of metformin in type 1 obesity was found to be helpful in reducing obesity and periodontitis, reducing the metalloproteinases 1, 3, 8, V that are present in periodontium of obese subjects.

Keywords: SSTR2; GCF; Visfatin; Adiponectin; Metformin; Periodontitis; Obesity

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Citation: Kulvinder Kochar Kaur., et al. “Control of Somatostatin Receptor 2 (SSTR2) by Proinflammatory, Microbial and Obesity-Associated Signals in Gingival Crevicular Fluid (GCF), Role of Visfatin and Other Adipokines in Obesity with Periodontitis, Besides Diurnal Rhythms-A Systemic Review to Update the Association of Oral Health with Obesity”. EC Dental Science 19.1 (2020): 01-11.

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