Research Article
Volume 20 Issue 12 - 2021
A New Approach in Managing Temporomandibular Disorders with Photo Biomodulation

Georgiana Kosmetatou1,2*, Edit Xhanjanka3, Panagiotis G Georgakopoulos1,2, Aggelos-Taxiarchis Georgakopoulos2, Gianna Dipalma1,2, Francesco Inchingolo1,2 and Ioannis P Georgakopoulos1,2

1Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy
2World Academy of Growth Factors and Stem Cells in Dentistry
3Department of Prosthodontics, Faculty of Dental Medicine, University of Medicine, Tirana, Albania
*Corresponding Author: Georgiana Kosmetatou, Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy.
Received: November 02, 2021; Published: November 29, 2021


Background: Temporomandibular disorders are very frequent among adults. One third of adult people report symptoms, which include jaw and myofacial pain, earaches, headaches or clicking. The causes of temporomandibular disfunction are abnormal occlusion, parafunctional habits (bruxism, lip biting), stress and abnormalities of the intra-articular disc. Therapies for these disorders are considered to be invasive, pharmacheutical and non pharmaceutical. Most patients refer improvement after noninvasive treatments. Low-Level Laser Therapy (LLLT) is a kind of physical treatment which can be used for reducing the symptoms of temporomandibular joint disorders. The clinical effects of LLLT are anti-inflammatory, analgesic, bactericidal and biostimulating. These effects can be helpful in reducing pain. Nowadays, this method is used by many clinicians in the dental field. The purpose of this study is to present the effectiveness of LLLT in reducing pain in TMD and emphasise that it can be easily used by the patient.

Materials and Methods: All 8 systematically healthy patients who were selected for the study suffered from myogenic TMD-assosiated orofacial pain. Six of them were treated with real LLLT for 4 weeks and two of them with the same protocol received placebo laser devices. Each patient was instructed to express its pain level just before, 1 week , 2 weeks , 3 weeks and 1 month after the treatment.

Results: There was a significant reduction of pain in the group of patients who received real LLLT treatment from the second week of treatment. LLLT showed no improvement in the placebo group.

Conclusion: It might be concluded that LLLT is beneficial in patients with severe TMD’s. It may be a treatment method for patients who are interested in noninvasive therapies.

 Keywords: Temporomandibular Disorders; Low-Level Laser Therapy; Noninvasive Dentistry; Temporomandibular Pain; Effectiveness of Low-Level Laser Therapy


    1. Buescher Jennifer J. “Temporomandibular joint disorders”. American Family Physician10 (2007): 1477-1482.
    2. Chellappa Deepika and Manigandan Thirupathy. “Comparative efficacy of low-Level laser and TENS in the symptomatic relief of temporomandibular joint disorders: A randomized clinical trial”. Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research1 (2020): 42-47.
    3. Fikácková H., et al. “Effectiveness of low-level laser therapy in temporomandibular joint disorders: a placebo-controlled study”. Photomedicine and Laser Surgery4 (2007): 297-303.
    4. Gauer Robert L and Michael J Semidey. “Diagnosis and treatment of temporomandibular disorders”. American Family Physician6 (2015): 378-386.
    5. Madani Azamsadat., et al. “A randomized clinical trial comparing the efficacy of low-level laser therapy (LLLT) and laser acupuncture therapy (LAT) in patients with temporomandibular disorders”. Lasers in Medical Science1 (2020): 181-192.
    6. Magri Laís Valencise., et al. “Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain”. Lasers in Medical Science2 (2017): 419-428.
    7. Maia Mila Leite de Moraes., et al. “Effect of low-level laser therapy on pain levels in patients with temporomandibular disorders: a systematic review”. Journal of Applied oral Science: Revista FOB6 (2012): 594-602.
    8. Núñez Silvia Cristina., et al. “Management of mouth opening in patients with temporomandibular disorders through low-level laser therapy and transcutaneous electrical neural stimulation”. Photomedicine and Laser Surgery1 (2006): 45-49.
    9. Scrivani Steven J., et al. “Temporomandibular disorders”. The New England Journal of Medicine25 (2008): 2693-2705.
    10. Kulekcioglu Sevinc., et al. “Effectiveness of low-level laser therapy in temporomandibular disorder”. Scandinavian Journal of Rheumatology2 (2003): 114-118.
    11. Shukla D and Muthusekhar MR. “Efficacy of low-level laser therapy in temporomandibular disorders: A systematic review”. National Journal of Maxillofacial Surgery1 (2016): 62-66.
    12. Gang-Zhu Xu., et al. "Low-Level Laser Therapy for Temporomandibular Disorders: A Systematic Review with Meta-Analysis". Pain Research and Management (2018): 13.
    13. Petrucci A., et al. “Effectiveness of low-level laser therapy in temporomandibular disorders: a systematic review and meta-analysis 25 (2011): 298-307.
    14. Xu Gang-Zhu., et al. “Low-Level Laser Therapy for Temporomandibular Disorders: A Systematic Review with Meta-Analysis”. Pain Research and Management (2018): 4230583.
    15. Herpich Carolina Marciela., et al. "Analysis of laser therapy and assessment methods in the rehabilitation of temporomandibular disorder: a systematic review of the literature”. Journal of Physical Therapy Science1 (2015): 295-301.
    16. Chen J., et al. “Efficacy of low-level laser therapy in the treatment of TMDs: a meta-analysis of 14 randomised controlled trials”. Journal of Oral Rehabilitation4 (2015): 291-299.
    17. Bjordal Jan M., et al. “A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders”. The Australian Journal of Physiotherapy2 (2003): 107-116.
Citation: Georgiana Kosmetatou., et al. “A New Approach in Managing Temporomandibular Disorders with Photo Biomodulation”. EC Dental Science 20.12 (2021): 54-59.

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