Research Article
Volume 20 Issue 12 - 2021
Dental Anomalies after Chemotherapy in Childhood Cancer Survivors: A Cross Sectional Study

Ghada Adel Tahoun1*, Sara Ahmed Mahmoud3, Lobna Mohamed Shalaby2 and Amr Ezzat Abd EL Latif3

1Department of Dentistry, Children’s Cancer Hospital Egypt
2Department of Pediatric Oncology, Children’s Cancer Hospital Egypt 57357
3Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Egypt
*Corresponding Author: Ghada Adel Tahoun, Department of Dentistry, Children's Cancer Hospital Egypt.
Received: November 05, 2021; Published: November 29, 2021


Background: Since cancer therapy regimens mostly involve combinations of chemotherapy, radiotherapy, bone marrow transplantation and/or surgery, determining the causality of the dental anomalies observed in cohorts of childhood cancer survivors has been a challenge. Fortunately, effects of radiotherapy and surgery are localized however, due to the lack of specificity of these agents, chemotherapy affects the entire body. Therefore, this study aims to describe the effect of chemotherapy on dental development.
Methods: A total of 144 cancer survivors were selected from Children Cancer Hospital Egypt 57357 using stratified random sampling. The selected subjects matched the following criteria: (1) cancer survivors who were at least 6 years old (2) children who first started receiving chemotherapy at 4 years old or younger. We excluded (1) children who received radiotherapy on head and/or neck (2) children who received bone marrow transplantation (3) children with any associated developmental anomalies. Eligible subjects were assessed radiographically for dental anomalies of the permanent dentition using Holtta's Defect Index (DeI).
Results: 70.14% of the subjects had at least one dental anomaly (DeI ≥ 1). The highest mean DeI was of bone tumors while the least mean was of soft tissue sarcoma. The most frequently detected anomaly was microdontia (56.9%). Microdontia occurred most commonly (71%) in Acute Myeloid Leukemia and Non-Hodgkin's Lymphoma, while root resorption and hypdontia affected mostly bone tumors (66.67%, 33.33%, respectively).

Conclusion: This study confirms that children who receive antineoplastic chemotherapy before the age of 4 years are at high risk of developing dental anomalies.

Keywords: Tooth Abnormalities; Neoplasms; Drug therapy; Anadontia; Tooth Root; Tooth Crown; Cancer Survivors


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Citation: Ghada Adel Tahoun., et al. “Dental Anomalies after Chemotherapy in Childhood Cancer Survivors: A Cross Sectional Study”. EC Dental Science 20.12 (2021): 46-53.

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