Research Article
Volume 20 Issue 11 - 2021
Applications of Hyaluronic Acid in Treatment of Periimplant Diseases. A Systematic Review
Nektaria Giavrouta1, Panagiotis Karakostas2 and Sotiria Davidopoulou3*
1School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
2Postgraduate Student, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
3Academic Fellow, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
*Corresponding Author: Sotiria Davidopoulou, Academic Fellow, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Received: September 17, 2021; Published: October 26, 2021


Objective: Hyaluronic acid is a viscous glycosaminoglycan detected in all periodontal tissues in varying quantities. It may act as a mediator of periodontal tissue regeneration, because of its presence in periodontal tissues and its anti-inflammatory capacity. The objective of this systematic review was to evaluate the potential effect of hyaluronic acid in the treatment of perimucositis and peri-implantitis.

Methods: The international literature in 9 electronic databases was thoroughly studied, using a specific search strategy. The screening process included 6 publications, 5 of them regarding to peri-implantitis and 1 of them relating to perimucositis.

Results: Four RCTs and 2 split mouth studies were examined that showed that although there is a significant difference in BOP, PD and CAL indices were not improved, after the use of hyaluronic acid.

Conclusion: This is the first systematic review regarding HA and treatment of periimplant diseases. The use of hyaluronic acid as an adjunct may have a positive effect in peri-implantitis and no noticeable effect in perimucositis treatment.

Keywords: Hyaluronic Acid; Hyaluron; Peri-Implantitis; Perimucositis; Treatment


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Citation: Nektaria Giavrouta., et al. “Applications of Hyaluronic Acid in Treatment of Periimplant Diseases. A Systematic Review”. EC Dental Science 20.11 (2021): 28-36.

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