Research Article
Volume 20 Issue 11 - 2021
Applications of Hyaluronic Acid in Treatment of Periimplant Diseases. A Systematic Review
Nektaria Giavrouta1, Panagiotis Karakostas2 and Sotiria Davidopoulou3*
1School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
2Postgraduate Student, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
3Academic Fellow, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece
*Corresponding Author: Sotiria Davidopoulou, Academic Fellow, Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Received: September 17, 2021; Published: October 26, 2021




Abstract

Objective: Hyaluronic acid is a viscous glycosaminoglycan detected in all periodontal tissues in varying quantities. It may act as a mediator of periodontal tissue regeneration, because of its presence in periodontal tissues and its anti-inflammatory capacity. The objective of this systematic review was to evaluate the potential effect of hyaluronic acid in the treatment of perimucositis and peri-implantitis.

Methods: The international literature in 9 electronic databases was thoroughly studied, using a specific search strategy. The screening process included 6 publications, 5 of them regarding to peri-implantitis and 1 of them relating to perimucositis.

Results: Four RCTs and 2 split mouth studies were examined that showed that although there is a significant difference in BOP, PD and CAL indices were not improved, after the use of hyaluronic acid.

Conclusion: This is the first systematic review regarding HA and treatment of periimplant diseases. The use of hyaluronic acid as an adjunct may have a positive effect in peri-implantitis and no noticeable effect in perimucositis treatment.

Keywords: Hyaluronic Acid; Hyaluron; Peri-Implantitis; Perimucositis; Treatment

References

  1. Casale M., et al. “Hyaluronic acid: Perspectives in dentistry. A systematic review”. International Journal of Immunopathology and Pharmacology (2016): 572-582.
  2. Zhao N., et al. “Effect of hyaluronic acid in bone formation and its applications in dentistry”. Journal of Biomedical Materials Research (2016): 1560-1569.
  3. Ijuin C., et al. “Regulation of hyaluronan synthase gene expression in human periodontal ligament cells by tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma”. Archives of Oral Biology (2001): 767-772.
  4. Takahashi K., et al. “The effects of hyaluronan on matrix metalloproteinase3 (MMP-3), interleukin-1beta (IL-1b), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis”. Osteoarthritis Cartilage (1999): 182-190.
  5. Feinberg RN., et al. “Hyaluronate in vasculogenesis”. Science (1983): 1177-1179.
  6. Mitsui Y., et al. “Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 ininterleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease”. Journal of Orthopaedic Research (2008): 1032-1037.
  7. West DC., et al. “Angiogenesis induced by degradation products of hyaluronic acid”. Science (1985): 1324-1326.
  8. Fakhari A., et al. “Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment”. Acta Biomaterialia (2013): 7081-7092.
  9. Banks J., et al. “Anionic polysaccharide production and tyrosinase activation in cultured human melanoma cells”. Cancer Research (1976): 424-431.
  10. Lindhe J., et al. “Critical probing depths" in periodontal therapy”. Journal of Clinical Periodontology4 (1982): 323-336.
  11. Badersten A., et al. “Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis”. Journal of Clinical Periodontology1 (1984): 63-76.
  12. Caffesse RG., et al. “Scaling and root planing with and without periodontal flap surgery”. Journal of Clinical Periodontology3 (1986): 205-210.
  13. Eliezer Meizi., et al. “Hyaluronic acid as adjunctive to non-surgical and surgical periodontal therapy: a systematic review and meta-analysis”. Clinical Oral Investigations9 (2019): 3423-3435.
  14. Bertl K., et al. “Hyaluronan in non-surgical and surgical periodontal therapy: A systematic review”. Journal of Clinical Periodontology 42 (2015): 236-246.
  15. Moher D., et al. “Preferred reporting items for systematic revies and meta-analyses: The PRISMA statement”. PLOS Medicine (2009): 6.
  16. Higgins, J. P., et al. “Chapter 8: Assessing risk of bias in a randomized trial”. (2021).
  17. Bertl K., et al. “Can hyaluronan injections augment deficient papillae at implant-supported crowns in the anterior maxilla? A randomized controlled clinical trial with 6 months follow-up”. Clinical Oral Implants Research (2017): 1054-1061.
  18. Lopez MA., et al. “The use of hyaluronic acid as an adjuvant in the management of mucositis”. Journal of Biological Regulators and Homeostatic Agents (2017): 115-118.
  19. Lopez MA., et al. “The use of hyaluronic acid as an adjuvant in the management of peri-implantitis”. Journal of Biological Regulators and Homeostatic Agents (2017): 123-127.
  20. Nobre A., et al. “Non-surgical treatment of peri-implant pockets: an exploratory study comparing 0.2% chlorhexidine and 0.8% hyaluronic acid”. The Canadian Journal of Dental Hygiene (2009): 25-30.
  21. Sánchez-Fernández E., et al. “Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial”. Journal of Periodontal and Implant Science (2021): 63-74.
  22. Soriano-Lerma A., et al. “Short-term effects of hyaluronic acid on the subgingival microbiome in peri-implantitis: A randomized controlled clinical trial”. Journal of Periodontology (2020): 734-745.
  23. Nobre A., et al. “Peri-implant maintenance of immediate function implants: a pilot study comparing hyaluronic acid and chlorhexidine”. International Journal of Dental Hygiene (2007): 87-94.
Citation: Nektaria Giavrouta., et al. “Applications of Hyaluronic Acid in Treatment of Periimplant Diseases. A Systematic Review”. EC Dental Science 20.11 (2021): 28-36.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


August Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the August issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before August 18, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.