Research Article
Volume 20 Issue 11 - 2021
Evaluation of Ph of a Novel Bioceramic Material for Use in Endodontic Practice: An In-Vitro Analysis
Harpreet Singh1* and Pavita Kataria2
1Dean, BJS Research Institute and Professor, Endodontics, BJS Dental College and Hospital, Ludhiana, India
2Senior Lecturer, Periodontology, BJS Dental College and Hospital, Ludhiana, India
*Corresponding Author: Harpreet Singh, Dean, BJS Research Institute and Professor, Endodontics, BJS Dental College and Hospital, Ludhiana, India.
Received: August 04, 2021; Published: October 25, 2021


Introduction: Bioceramic materials have a come long way in terms of their potential role in critical tooth saving procedures, especially during endodontic management. The process of developing new materials with MTA like properties is still in progress in order to make materials which are clinically efficient but at the same time cost effective. One of the essential pre-requisites of these bioceramic materials is their ability to attain a highly alkaline pH after setting so that they can exhibit the osteogenic potential. The current study was carried out in these lines in order to evaluate the alkalinity of the newly introduced MTA in the Indian market in order to explore its osteogenic potential as the biological properties of MTA are attributed to its alkalinity.

Aim: To investigate the pH of a novel Bioceramic material, MTA (Maarc Dental, India) in order to validate its osteogenic potential.

Methodology: MTA Powder was mixed with its special liquid as per the manufacturer’s instructions, ensuring the complete dissolution of the powder particles. 20 polyethylene tubes measuring 3 mm in diameter and 2 mm in height were filled with freshly prepared material. The samples were sealed in tubes containing 10 ml of distilled water and stored at 37 degree celsius. The pH was measured after 3 hours, 24 hours and 48 hours using a calibrated pH meter.

Observations and Results: The maximum pH was observed to be 10.59 after 24 hours with a mean of 10.52. After 24 hours, a gradual fall in pH was observed in the samples.

Conclusion: Within the parameters set in this study, it was concluded that new MTA seems to be promising enough as it obtained a high alkaline pH after 24 hours of mixing. However, long term clinical evaluation in patients is required to support the laboratory findings.

Keywords: Alkalinity; Bioceramics; Endodontics; MTA; pH


  1. Tabassum S and Khan FR. “Failure of endodontic treatment: The usual suspects”. European Journal of Dentistry1 (2016): 144-147.
  2. LeGeros RZ. “Properties of osteoconductive biomaterials: calcium phosphates”. Clinical Orthopaedics and Related Research 395 (2002): 81-98.
  3. Tang Z., et al. “The material and biological characteristics of osteoinductive calcium phosphate ceramics”. Regenerative Biomaterials 1 (2018): 43-59.
  4. Rusin Zhao., et al. “Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments”. Molecule 26 (2021): 3007.
  5. Hernán Coaguila-Llerena., et al. “Physicochemical Properties of a Bioceramic Repair Material – BioMTA”. Brazilian Dental Journal5 (2020): 511-515.
  6. Kaur M., et al. “MTA versus Biodentine: Review of Literature with a Comparative Analysis”. Journal of Clinical and Diagnostic Research8 (2017): ZG01-ZG05.
  7. Youssef AR., et al. “Effects of mineral trioxide aggregate, calcium hydroxide, biodentine and Emdogain on osteogenesis, Odontogenesis, angiogenesis and cell viability of dental pulp stem cells”. BMC Oral Health 19 (2019): 133.
  8. Galal M., et al. “Solubility, pH change, and calcium ion release of low solubility endodontic mineral trioxide aggregate”. Bulletin of the National Research Centre 44 (2020): 42.
  9. Shekhar S., et al. “Comparative pH and calcium ion release in newer calcium silicate-based root canal sealers”. Endodontology 31 (2019): 29-33.
  10. Lee SJ., et al. “Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations”. The Journal of Endodontics 19 (1993): 541-544.
  11. Torabinejad M and Chivian N. “Clinical applications of mineral trioxide aggregate”. The Journal of Endodontics 3 (1999): 197-205.
  12. Abedi HR and Ingle JI. “Mineral trioxide aggregate: a review of a new cement”. The Journal of the California Dental Association 12 (1995): 36-39.
  13. Howard W Roberts., et al. “Mineral trioxide aggregate material use in endodontic treatment: A review of the literature”. Dental Materials 24 (2008): 149-164.
  14. Singh H., et al. “Biodentin: A promising dentin substitute”. JBR Journal of Interdisciplinary Medicine and Dental Science 5 (2014): 1000140.
  15. Stella Maris de Freitas Lima., et al. “Improvement of reparative bioceramics in endodontics- A clinical review”. Biomedical Journal of Scientific and Technical Research 3 (2020): 18306-183010.
  16. Eliaz N and Metoki N. “Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications”. Materials4 (2017): 334.
  17. Raghavendra SS., et al. “Bioceramics in endodontics - a review”. Journal of Istanbul University Faculty of Dentistry3-1 (2017): S128-S137.
  18. Amini Ghazvini S., et al. “Ion release and pH of a new endodontic cement, MTA and Portland cement”. The Iranian Endodontic Journal2 (2009): 74-78.
  19. Macwan C and Deshpande A. “Mineral Trioxide Aggregate (MTA) in dentistry: A review of literature”. International Journal of Oral Health and Medical Research 6 (2014): 71-74.
Citation: Harpreet Singh and Pavita Kataria. “Evaluation of Ph of a Novel Bioceramic Material for Use in Endodontic Practice: An In-Vitro Analysis”. EC Dental Science 20.11 (2021): 03-09.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

January Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 14, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.