Review Article
Volume 20 Issue 3 - 2021
Comparative Analysis of Intravenous Sedation Techniques in Dentistry: A Systematic Review
Omar Mario Masabni1*, Karissa Burgos2, Michael Haddow3, Anthony L Neely4 and Bassam M Kinaia5
1Affiliate Professor, Periodontist, Division of Clinical Dentistry, University of Detroit Mercy School of Dentistry, MI, USA
2Postgraduate Orthodontics Resident, Graduate Orthodontics, University of Colorado School of Dental Medicine, CO, USA
3Clinical Associate Professor, Division of Graduate Periodontics, University of Detroit Mercy School of Dentistry, Detroit, MI, USA
4Associate Professor, Division of Graduate Periodontics, University of Detroit Mercy School of Dentistry, Detroit, MI, USA
5Director and Associate Professor, Division of Graduate Periodontics, University of Detroit Mercy School of Dentistry, Detroit, MI, USA
*Corresponding Author: Omar Mario Masabni, Periodontist and Clinical Affiliate Professor, Division of Clinical Dentistry, University of Detroit Mercy School of Dentistry, Detroit, MI, USA.
Received: November 17, 2020; Published: February 27, 2021


Introduction: As sedation dentistry increase in demand, the need for a gold standard becomes necessary. Several drug combinations are used to achieve optimal sedation with varied rates of success.

Aim and Objective: The aim of this study was to analyze outcomes of conscious intravenous sedation (IVS) for dental procedures.

Materials and Methods: Electronic search of the MEDLINE (PubMed) database up to April 2018 was conducted. Two reviewers independently and in duplicates identified eligible studies using specific data extraction and assessment forms. The PRISMA and MECIR guidelines were the basis for the current systematic review analyses.

Results: The search identified 567 potential publications. After review of abstracts and titles, 42 articles qualified for full-text review where seven studies satisfied the inclusion criteria allowing two analyses. The first analysis compared single versus multiple drugs showing weighted mean recovery time of 30.3 5 ± 4.22 min (single) versus 32.50 ± 13.50 min (multiple) and procedure time of 29.85 ± 5.18 min (single) versus 50.50 ± 20.69 min (multiple). The second analysis showed weighted mean of recovery time 12.1 ± 0.9 min; procedure time 36.8 ± 6.2 min; total dosage 255.8 ± 13.0 mg for propofol with nitrous versus recovery time 22.7 ± 8.9 min; procedure time 48.1 ± 8.6 min; total dosage 160.7 ± 15.8 mg for propofol as a single/in combination with other drugs without nitrous.

Conclusion: The recovery time and procedure length were shorter in trials using single drugs compared to multiple drugs. Further, the weighted mean showed that the use of propofol alone resulted in longer recovery time and procedure length but a lower total dosage than when combined to propofol and nitrous oxide. Despite these findings, data should be interpreted with caution due to high heterogeneity. The high number of patients in the multiple drugs compared to low number of patients in the single drug group could skew the results creating bias. Finally, definitive conclusions regarding conscious sedation cannot be made and data should be interpreted with caution due to limited number of studies.


Keywords: Anesthesia; Conscious Sedation; Dental; Nitrous Oxide, Systematic Review


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Citation: Omar Mario Masabni., et al. “Comparative Analysis of Intravenous Sedation Techniques in Dentistry: A Systematic Review”. EC Dental Science 20.3 (2021): 91-102.

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