Research Article
Volume 20 Issue 3 - 2021
Sub-Gingival and Intra-Canal Irrigation by 2% Chlorhexidine Gluconate (Consepsis®) as Adjunctive Therapy in the Management of Periodontal Pocket
Mohammed MA Abdullah Al-Abdaly1*, Hussein Masoud Alqahtani2, Wael Mohammed Kedwan Al-Shehri3 and Saleh Salem Saleh Al- Shehri4
1Periodontics and Community Dental Sciences Department, College of Dentistry, King Khalid University, Saudi Arabia
2Prince Sultan Armed Forces Hospital, AlMadinah AlMunawarah, Saudi Arabia
3Ministry of Health, Bream Al-Seleel Primary Healthcare Center, Abha, Saudi Arabia
4Ministry of Health, Tareeb Primary Health Care Center, Abha, Saudi Arabia
*Corresponding Author: Mohammed MA Abdullah Al-Abdaly, Periodontics and Community Dental Sciences Department, College of Dentistry, King Khalid University, Saudi Arabia.
Received: February 11, 2021; Published: February 26, 2021


Background: In periodontics and endodontics, the residual chlorhexidine antibacterial effects are attributed to its ability to attach with the hydroxyapatite and release it gradually. Consequently, it could keep a persistent level to create continuous antibacterial effects inside the periodontal pocket and the root canal for a long duration. Thus, the present study aimed to assess the impact of sub-gingival and intra-canal irrigation with 2% Chlorhexidine gluconate (Consepsis®) as adjunctive therapy in the management of periodontal pocket.

Materials and Methodology: This study included thirty patients (50% males and 50% females) with mild to moderate periodontal pocket depth (4 - 6 mm) adjacent to teeth need endodontic therapy (120 teeth) was divided into three equal groups (10 patients included 40 teeth per group).

Each case was treated with endodontic and periodontal therapy, where the treatment was root canal therapy (RCT) and scaling and root planing (SRP) alone in group I. Moreover, intra-canal irrigation by Consepsis® in group II and sub-gingival irrigation by Consepsis® in group III. Plaque index (PLI), Gingival index (GI) and periodontal pocket depth (PPD) were recorded at baseline, 4 weeks, and 6 weeks follow up. Data were collected and analyzed using SPSS software, version 21 and through t-test, to assess the statistical significance differences p-value (p ˂ 0.05). 

Results: In the comparison of clinical findings between groups I, II and III, the results of the current study revealed a reduction in all the clinical parameters without statistically significant differences except GI and PPD in the third visit (after six weeks post-treatment), there were statistically significant differences of PPD at the second visit (p = 0.034), and there were highly statistically significant differences of GI and PPD at the third visit (p = 0.001*).

Conclusion: In the current study, Consepsis® sub-gingival and intra-canal irrigation as an adjunct to SRP improved the results of the traditional endodontic and periodontal therapy, due to its bactericidal effect on aerobic, and anaerobic bacteria. Thus, it may be considered as adjunctive therapy in the management of periodontal pocket of endodontic-periodontal lesions.


Keywords: Consepsis®; Intra-Canal Irrigation; Sub-Gingival Irrigation


  1. Socransky SS and Haffajee AD. “The Bacterial Etiology of Destructive Periodontal Disease: Current Concepts”. Journal of Periodontology 63 (1992): 322-331.
  2. Genco R., et al. “Consensus report. Periodontal diseases: Pathogenesis and microbial factors”. Annals of Periodontology 1 (1996): 926-932.
  3. Cobb CM. “Clinical significance of nonsurgical periodontal therapy: An evidence based perspective of scaling and root planing”. Journal Of Clinical Periodontology 2 (2002): 616.
  4. Cobb CM. “Microbes, inflammation, scaling and root planing, and the periodontal condition”. Journal of Dental Hygiene 3 (2008): 49.
  5. Rams TE. and Slots J. “Local delivery of antimicrobial agents in the periodontal pocket”. Periodontology 2000 10 (1996): 139-159.
  6. Greenstein G. “Research, Science and Therapy Committee of the American Academy of Periodontology. Position paper: The role of supra- and subgingival irrigation in the treatment of periodontal diseases”. Journal of Periodontology 76 (2005): 2015-2027.
  7. Douglasss CW., et al. “Cross-sectional studies in periodontal disease current status and implications for dental practice”. Advances in Dental Research 1 (1993): 25-31.
  8. Skoglund A. and Persson G. “A follow-up study of apicoectomized teeth with–up total loss of buccal bone plate”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 59 (1985): 78-81.
  9. Socransky SS. and Haffajee AD. “Dental biofilms: difficult therapeutic targets”. Periodontology 2000 28 (2002): 12-55.
  10. Berutti E., et al. “Penetration ability of different irrigants into dentinal tubules”. Journal of Endodontics 12 (1997): 725-727.
  11. Ringel AM., et al. “In vivo evaluation of chlorhexidine gluconate solution and sodium hypochlorite solution as root canal irrigants”. Journal of Endodontics 5 (1982): 200-204.
  12. McDonell G. and Russell AD. “Antiseptics and disinfectants: activity, action, and resistance”. Clinical Microbiology Reviews 12 (1999): 1479.
  13. Silness J and Loe H. “Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition”. Acta Odontologica Scandinavica 22 (1964): 122-135.
  14. Loe H and Silness J. “Periodontal disease in pregnancy I. Prevalence and severity”. Acta Odontologica Scandinavica 21 (1963): 533-551.
  15. Genco J. “Using antimicrobial agents to manage periodontal diseases”. Journal of the American Dental Association 122 (1991): 31-38.
  16. Rotstein I and Simon JH. “The endo-perio lesion: a critical appraisal of the disease condition”. Endodontic Topics 13 (2006): 44-50.
  17. Van Der Sluis LWM., et al. “The influence of volume, type of irrigant and flushing method on removing artificially placed dentine debris from the apical root canal during passive ultrasonic irrigation”. International Endodontic Journal 39 (2006): 472-476.
  18. Wang Q., et al. “Prevalence of Enterococcus faecalis in saliva and filled root canals of teeth associated withapical periodontitis”. International Journal of Oral Science 4 (2012): 19-23.
  19. Kerns DG. and Glickman GN. “Endodontic and periodontal interrelationships”. In: Cohen S, Hargreaves KM. Eds. Pathways of the pulp. St. Louis: MosbyInc (2006): 650-670.
  20. Killoy WJ. and Polson AM. “Controlled local delivery of antimicrobials in the treatment of periodontitis”. Dental Clinics of North America 42 (1998): 263‑283.
  21. Hull P S. “Chemical inhibition of Plaque”. Journal of Clinical Periodontology 7 (1980): 431-443.
  22. Lander P E., et al. “The antimicrobial and clinical effects of a single subgingival irrigation of chlorohexidine in advanced periodontal lesions”. Journal of Clinical Periodontology 13 (1986): 74-80.
  23. Raheja J., et al. “Evaluation of efficacy of chlorhexidine intracanal medicament on the periodontal healing of concomitant endodontic periodontal lesions without communication: an interventional study”. Journal of Periodontology 8 (2014): 1019-1026.
  24. Basrani B1., et al. “Substantive antimicrobial activity in chlorhexidine-treated human root dentin”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 2 (2002): 240-245.
  25. Gonzalez-Lopez S., et al. “Effect of CHX on the decalcifying effect of 10% Citric Acid, 20% Citric Acid or 17%EDTA”. Journal of Endodontics 8 (2006): 781-784.
  26. De Lucena JM., et al. “Antimicrobial effectiveness of intracanal medicaments on Enterococcus faecalis: chlorhexidine versus octenidine”. International Endodontic Journal 1 (2013): 53-61.
  27. Chen SY., et al. “The influence of endodontic treatment on periodontal wound healing”. Journal of Clinical Periodontology 24 (1997): 44956.
  28. Southard SR., et al. “The Effect of 2% Chlorhexidine Digluconate Irrigation on Clinical Parameters and the Level of Bacteroides gingivalis in Periodontal Pockets”. Journal of Periodontology6 (1989): 302-309.
  29. Colombo AP., et al. “Effects of non-surgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results”. Journal of Periodontology 76 (2005): 778-784.
  30. Faveri M., et al. “Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: A randomized, placebo-controlled clinical trial”. Journal of Clinical Periodontology 33 (2006): 819-828.
  31. Kaldahl WB., et al. “A review of longitudinal studies that compared periodontal therapies”. Journal of Periodontology 64 (1993): 243-253.
  32. Morrison EC., et al. “Short-term effects of initial, nonsurgical periodontal treatment (hygienic phase)”. Journal of Clinical Periodontology 7 (1980): 199-211.
  33. Sekino S., et al. “Effect of various chlorhexidine regimens on salivary bacteria and de novo plaque formation”. Journal of Clinical Periodontology 30 (2003): 919-925.
Citation: Mohammed MA Abdullah Al-Abdaly., et al. “ESub-Gingival and Intra-Canal Irrigation by 2% Chlorhexidine Gluconate (Consepsis®) as Adjunctive Therapy in the Management of Periodontal Pocket”. EC Dental Science 20.3 (2021): 49-60.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 28, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to