Review Article
Volume 20 Issue 2 - 2021
A ‘Gutta Percha Based Endodontic Sealer’ with an Excellent Flow: Gutta Flow
Harpreet Singh1* and Amanpreet Singh2
1Head, BJS Research Institute, Professor, Department of Endodontics, BJS Dental College, Hospital and Research Institute, Ludhiana, India
2Associate Professor, Department of Pedodontics, BJS Dental College, Hospital and Research Institute, Ludhiana, India
*Corresponding Author: Harpreet Singh, Head, BJS Research Institute, Professor, Department of Endodontics, BJS Dental College, Hospital and Research Institute, Ludhiana, India.
Received: November 16, 2020; Published: January 30, 2021


The success of endodontic therapy relies on multiple contributing factors, with each one having a substantial role to play. While focusing intricately on each step involved in the procedure of root canal treatment, the aim is targeted at obtaining three dimensional obturation of the root canal system. Of the two main materials used in obturation, the gutta percha component is standard across the globe, owing to its exceptionally magnificent properties while the endodontic sealer, the second component, is variable. This is for the fact that there is a plethora of sealers available and their usage is operator dependent, more so as per personal inclination. While the dental professionals are still looking for an ‘ideal endodontic sealer’, it seems quite appropriate that a sealer which contains gutta percha as one of its major components, can be crowned with this title. Guttaflow 2, a gutta percha based sealer fits perfectly in this category and may put an end to the seamless search of an ideal endodontic sealer.

Keywords: Endodontic Sealer; Endodontic Therapy; Guttaflow 2; Gutta Percha


  1. Estrela Carlos., et al. “Characterization of Successful Root Canal Treatment”. Brazilian Dental Journal 1 (2014): 3-11.
  2. Ruddle CJ. “Endodontic Triad for Success: The Role of Minimally Invasive Technology”. Dentistry Today5 (2015): 78-80.
  3. Singh H., et al. “Endodontic sealers: Current concepts and comparative analysis”. The Open Dentistry Journal 1 (2015): 32-37.
  4. Marín-Bauza GA., et al. “Physicochemical properties of endodontic sealers of different bases”. Journal of Applied Oral Science 4 (2012): 455-461.
  5. Fonseca DA., et al. “Biocompatibility of Root Canal Sealers: A Systematic Review of In vitro and In vivo Studies”. Materials24 (2019): 4113.
  6. Faria Jr., et al. “Comparative assessment of the flow rate of root canal sealers”. The Revista Odonto Ciência 2 (2010): 170-173.
  7. Savariz A., et al. “Long-term sealing ability of GuttaFlow versus Ah Plus using different obturation techniques”. Medicina Oral, Patologia Oral, Cirugia Bucal 6 (2010): e936-e941.
  8. Tracie M Zielinski and J Craig Baumgartner. “An evaluation of gutta flow and gutta percha in the filling of lateral grooves and depressions”. Journal of Endodontics 3 (2008): 295-298.
  9. Saygili G., et al.In vitro Cytotoxicity of GuttaFlow Bioseal, GuttaFlow 2, AH-Plus and MTA Fillapex”. The Iranian Endodontic Journal 3 (2017): 354-359.
  11. Mandal P., et al.In vitro cytotoxicity of guttaflow 2 on human gingival fibroblasts”. Journal of Endodontics 8 (2014): 1156-1159.
  12. Accardo C., et al. “A novel GuttaFlow sealer supports cell survival and attachment”. Journal of Endodontics 2 (2014): 231-234.
  13. Willershausen I., et al.In vitro analysis of the cytotoxicity and the antimicrobial effect of four endodontic sealers”. Head and Face Medicine 7 (2011): 15.
  14. Zoufan K., et al. “Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 5 (2011): 657-661.
  15. De-Deus G., et al. “The sealing ability of GuttaFlow in oval-shaped canals: An ex vivo study using a polymicrobial leakage model”. International Endodontic Journal 40 (2007): 794-799.
  16. Patil P., et al. “A comparison of apical sealing ability between GuttaFlow and AH plus: An In vitro study”. Journal of International Society of Preventive and Community Dentistry 4 (2016): 377-382.
  17. Varun K., et al. “Qualitative and quantitative comparative evaluation of sealing ability of guttaflow, thermoplasticized gutta percha and lateral compaction for root canal obturation: a cohort, controlled, ex-vivo study”. Oral Health and Dental Management 3 (2013): 155-161.
  19. Rafael Verardino de Camargo., et al. “Evaluation of the physicochemical properties of silicone- and epoxy resin-based root canal sealers”. Brazilian Oral Research 31 (2017): e72.
Citation: Harpreet Singh and Amanpreet Singh. “A ‘Gutta Percha Based Endodontic Sealer’ with an Excellent Flow: Gutta Flow”. EC Dental Science 20.2 (2021): 101-105.

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