Review Article
Volume 19 Issue 10 - 2020
Pentoxifylline, Tocopherol and Clodronate Combination for the Treatment of Osteoradionecrosis of the Jaws: A Systematic Review
Touil D1*, Oualha L2, Belkacem Chebil R2 and Sakly N3
1Assistant Professor in Oral Surgery and Oral Medicine, Department of Dentistry, Sahloul University Hospital, Research Laboratory LR12ES11, Dental Faculty of Monastir, University of Monastir, Tunisia
2Research Laboratory LR12ES11, Dental Faculty of Monastir, University of Monastir, Tunisia
3Faculty of Pharmacy of Monastir, University of Monastir, Tunisia
*Corresponding Author: Touil D, Assistant Professor in Oral Surgery and Oral Medicine, Department of Dentistry, Sahloul University Hospital, Research Laboratory LR12ES11, Dental Faculty of Monastir, University of Monastir, Tunisia.
Received: August 21, 2020; Published: October 31, 2020


Purpose of the Study: The purpose of this systematic review was to evaluate the efficacy and the tolerance of the pentoxifylline-tocopherol and clodronate combination (Pentoclo) as a new medical treatment for osteoradionecrosis of the jaws.

Materials and Methods: The bibliographic research was carried out on the databases Medline Via pubmed, google scholar and Cochrane library interface by using the key words; osteoradionecrosis, pentoxifylline, tocopherol, clodronate, jaws, mandible.

Results: After filtering articles based on inclusion and exclusion criteria and removing duplicates, 13 articles were retained in our study: 2 systematic reviews, 3 non randomised uncontrolled clinical trials and 6 descriptive studies. The Pentoclo combination seems to be effective and safe for the management of osteoradionecrosis of the jaws.

Conclusion: This protocol is well tolerated and could be promising for the treatment of osteoradionecrosis of the jaws. The greatest rates of healing and clinical improvement were seen in mild and moderate stages of ORN. Nevertheless, randomised, controlled clinical trials are needed to substantiate and confirm these data.

Keywords: Pentoxifylline; Tocopherol; Clodronate; Osteoradinecrosis


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Citation: Touil D., et al. “Pentoxifylline, Tocopherol and Clodronate Combination for the Treatment of Osteoradionecrosis of the Jaws: A Systematic Review”. EC Dental Science 19.11 (2020): 169-180.

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