Case Report
Volume 19 Issue 10 - 2020
Giant Central Ossifying Fibroma of the Maxilla: Case Report and Literature Review
Rodrigo Felipe Naranjo-Restrepo1, Francisco Levi Duque-Serna1, Vanessa Andrea Flórez-Arango2* and Mónica Vanessa Posso-Zapata2
1Oral and Maxillofacial Surgeon, University of Antioquia, Medellín, Colombia
2Postgraduate Student of Oral and Maxillofacial Surgery, University of Antioquia, Medellín, Colombia
*Corresponding Author: Vanessa Andrea Flórez-Arango, Postgraduate Student of Oral and Maxillofacial Surgery, University of Antioquia, Medellín, Colombia.
Received: August 12, 2020; Published: September 24, 2020




Abstract

The central ossifying fibroma is part of the fibro-osseous lesions and is considered a benign bone tumor. It occurs almost exclusively in the jaws, although cases have also been reported in frontal, orbital, paranasal and temporal bones. In its presentation in the jaws, it is generally an asymptomatic pathology, of slow growth; but as its size increases, it becomes disfiguring and can interfere with the basic functions of mastication, swallowing, phonation and even breathing. Because it is a lesion with defined borders, the treatment of choice is surgical excision. In this article we present the case of a 39-year-old female patient with a giant central ossifying fibroma in the anterior maxilla, accompanied by the clinical, imaging and histopathological findings and treatment used, and a review of recent literature on the characterization of fibro-osseous lesions.

Keywords: Fibro-Osseous Lesions; Central Ossifying Fibroma; Benign Neoplasm; Maxillary Sinus

References

  1. Su L., et al. “Distinguishing features of focal cemento-osseus and cemento-ossifying fibromas”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 84 (1997): 301-309.
  2. Neville B., et al. J Oral Maxillofac Pathol. 2nd Philadelphia: Saunders (2002): 563-564.
  3. WHO Classification of Head and Neck Tumours. 4th Lyon, France: IARC (2017).
  4. Santaolalla A., et al. “Fibroma osificante de seno etmoidal”. ORL-DIPS 29 (2002): 124-127.
  5. O'Reilly R., et al. “Ossifying fibroma of the temporal bone”. American Journal of Otolaryngology 21 (2000):131-135.
  6. Vlachou G., et al. “Ossifying fibroma of the temporal bone”. The Journal of Laryngology and Otology: JLO 115 (2001): 654-656.
  7. Selesnick S., et al. “Protuberant fibro-osseous lesions of the temporal bone: a unique clinicopathologic diagnosis”. American Journal of Otolaryngology 20 (1999): 394-396.
  8. Goh K., et al. “A case of isolated ossifying fibroma of the mastoid cavity of the temporal bones”. American Journal of Otolaryngology 27 (2005): 358-361.
  9. Chen Y., et al. “Gene mutations in sporadic ossifying fibroma of the jaws”. Diagnostic Pathology 1 (2016): 91.
  10. Horvai A and Jordan R. “Fibro-Osseous Lesions of the Craniofacial Bones: b-Catenin Immunohistochemical Analysis and CTNNB1 and APC Mutation Analysis”. Head and Neck Pathology 8 (2014): 291-297.
  11. Speight P and Carlos R. “Maxillofacial fibro-osseous lesions”. Current Diagnostic Pathology 3 (2014): 291-297.
  12. Hall G. “Fibro-osseous lesions of the head and neck”. Diagnostic Histopathology 4 (2012): 149-158.
  13. Mas M., et al. “Lesiones Fibro-Óseas Benignas Craneofaciales”. Diagnóstico Diferencial En Paleohistopatología.
  14. Brannon R and Fowler G. “Benign fibro-osseus lesions: a review of current concepts”. Advances in Anatomic Pathology 3 (2001): 126-143.
  15. DiCaprio M and Enneking W. “Fibrous dysplasia. Pathophysiology, evaluation, and treatment”. Journal of Bone and Joint Surgery American 87 (2005): 1848-1864.
  16. Jeyaraj P. “Histological Diversity, Diagnostic Challenges, and Surgical Treatment Strategies of Fibrous Dysplasia of Upper and Mid-Thirds of the Craniomaxillofacial Complex”. Annals of Maxillofacial Surgery 2 (2019): 289-314.
  17. Riddle N and Bui M. “Fibrous dysplasia”. Archives of Pathology and Laboratory Medicine 1 (2013): 134-138.
  18. Lee J., et al. “Clinical guidelines for the management of craniofacial fibrous dysplasia”. Orphanet Journal of Rare Diseases 1 (2012): S2.
  19. Stanton R., et al. “The surgical management of fibrous dysplasia of bone”. Orphanet Journal of Rare Diseases 1 (2012): S1.
  20. Toledano J., et al. “Florid cemento-osseous dysplasia: Report of 2 cases”. Journal of Clinical and Experimental Dentistry 11 (2018): e1145-e1148.
  21. Fenerty S., et al. “Florid cemento-osseous dysplasia: Review of an uncommon fibro-osseous lesion of the jaw with important clinical implications”. Skeletal Radiology 46 (2017): 581-590.
  22. Amarista F., et al. “Florid osseous dysplasia. Case report and literature review”. Revista Odontológica Mexicana 20 (2016): e120-e124.
  23. Carvalho A., et al. “The Florid cemento-bony dysplasia and the differential diagnosis”. Revista Cubana de Estomatologia3 (2011).
  24. Goncalves M., et al. “Clinical, radiographic, biochemical and histological findings of florid cemento-osseous dysplasia and report of a case”. Brazilian Dental Journal 3 (2005): 247-250.
  25. Singer S., et al. “Florid cemento-osseous dysplasia and chronic diffuse osteomyelitis: report of a simultaneous presentation and review of the literature”. Journal of the American Dental Association 7 (2005): 927-931.
  26. Park I., et al. “Calcifying tissue of florid cemento-osseous dysplasia easily involving chronic diffuse sclerosing osteomyelitis”. Basic and Applied Pathology 1 (2008): 107-109.
  27. Pitak-Arnnop P., et al. “Florid osseous dysplasia: report of a case presenting acute cellulitis”. Medicina Oral Patologia Oral y Cirugia Bucal 9 (2009): 461-464.
  28. Young S., et al. “Familial gigantiform cementoma: classification and presentation of a large pedigree”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 68 (1989): 740-747.
  29. Wang H., et al. “Familial gigantiform cementoma: distinctive clinical features of a large Chinese pedigree”. British Journal of Oral and Maxillofacial Surgery 53 (2015): 83-85.
  30. Ma C., et al. “Familial gigantiform cementoma: case report of an unusual clinical manifestation and possible mechanism related to “calcium steal disorder”. Medicine 95 (2016): e2956.
  31. Moshref M., et al. “Autosomal dominant gigantiform cementoma associated with bone fractures”. The American Journal of Medical Genetics - Part A 146A (2008): 644-668.
  32. Rossbach H., et al. “Familial gigantiform cementoma with brittle bone disease, pathologic fractures, and osteosarcoma: a possible explanation of an ancient mystery”. Pediatrics and Blood Cancer 44 (2005): 390-396.
  33. Wang H., et al. “Management strategy in patient with familial gigantiform cementoma: A case report and analysis of the literature”. Medicine (Baltimore) 50 (2017): e9138.
  34. Noffke C., et al. “Gigantiform cementoma in a child”. Dentomaxillofacial Radiology 41 (2012): 264-266.
  35. Sciubba J and Younai F. “Ossifying fibroma of the mandible and maxilla: review of 18 cases”. Journal of Oral Pathology and Medicine 18 (1989): 315-321.
  36. Montgomery A. “Ossifying fibroma of the jaw”. Archives of Surgery 15 (1927): 30-44.
  37. Walter J Jr., et al. “Aggressive ossifying fibroma of the maxilla: review of the literature and report of case”. Journal Oral Surgery 37 (1979): 276-286.
  38. Sherman R and Sternberg W. “Roentgen appearance of ossifying fibroma of bone”. Radiology 50 (1948): 295-309.
  39. Barnes L., et al. “World Health Organization classification. Pathology and genetics of head and neck tumours”. Lyon: IARC Press (2005).
  40. El-Mofty S. “Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 3 (2002): 296-304.
  41. Han J., et al. “Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases”. International Journal of Oral and Maxillofacial Surgery 3 (2016): 368-376.
  42. White S and Pharoah M. “Benign tumors. Oral radiology: principles and interpretation”. 7th Amsterdam: Elsevier (2013): 394-398.
  43. Eversole R., et al. “Benign fibro-osseous lesions of the craniofacial complex. A review”. Head and Neck Pathology 2 (2008): 77e202.
  44. Zegalie N., et al. “Ossifying fibromas of the jaws and craniofacial bones”. Diagnostic Histopathology9 (2015): 351-358.
  45. Ardila C and Duque F. “Juvenile trabecular ossyfying fibroma: presentation of three cases”. AMC4 (2014): 424-435.
  46. Malathi N., et al. “Psammomatoid juvenile ossifying fibroma of the jaws”. Journal of Oral and Maxillofacial Pathology 3 (2011): 326-329.
  47. Tamgadge S., et al. “Juvenile ossifying fibroma (Psammomatoid Type) of the maxilla”. Scientific Journal 3 (2009): 14-16.
  48. Gunaseelan R., et al. “Large cemento-ossifying fibroma of the maxilla causing proptosis: a case report”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 104 (2007): e21-e25.
  49. Domínguez L and Martín-Granizo R. “Análisis clínico, radiológico e histológico de los fibromas cementoosificantes de los maxilares”. Revista Española de Cirugía Oral y Maxilofacial 26 (2004): 31-40.
  50. Lombardi A., et al. “Fibroma osificante de mandíbula: Presentación de un caso y revisión de la literature”. Revista Española de Cirugía Oral y Maxilofacial 31 (2009): 242-248.
  51. Pérez S., et al. “Fibroma osificante maxilar: Presentación de un caso y revisión de la literature”. Medicina Oral 9 (2004): 333-339.
  52. Young N and Rowson J. “Cementifying fibroma of the frontal bone: A case report”. Journal of Oral and Maxillofacial Surgery 45 (2007): 667-669.
  53. Guzmán J and Hernández S. “Fibroma osificante etmoidal, caso en paciente pediátrico”. Revista De Otorrinolaringología Y Cirugía De Cabeza Y Cuello 36 (2008): 31-36.
  54. Mintz S and Velez I. “Central ossifying fibroma: an analysis of 20 cases and review of the literature”. Quintessence International 38 (2007): 221-227.
  55. Gomes-Ferreira P., et al. “Conservative Management of Central Cemento-Ossifying Fibroma”. The Journal of Craniofacial Surgery 1 (2017): e8-e9.
  56. Lv M., et al. “Which Patients With Ossifying Fibroma of the Jaws Would Be Suitable for Radical Ablative Surgery?” The Journal of craniofacial surgery 4 (2016): 927-931.
Citation: Vanessa Andrea Flórez-Arango., et al. “Giant Central Ossifying Fibroma of the Maxilla: Case Report and Literature Review”. EC Dental Science 19.10 (2020): 160-172.

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