Research Article
Volume 19 Issue 10 - 2020
Assessing the Accuracy of Mandibular Second Molar Tooth Development in Estimating Chronological Age
Sparice Estefanía, Villarroel-Dorrego Mariana*, Villasmil Gustavo, González Nieves, Frías Jennifer and Pérez-Alfonzo Ricardo
Universidad Central de Venezuela, Caracas, Venezuela
*Corresponding Author: Villarroel-Dorrego Mariana, Dental Research Institute, Facultad de Odontología, Universidad Central de Venezuela, Los Chaguaramos, Caracas, Venezuela.
Received: June 25, 2020; Published: September 19, 2020




Abstract

Introduction: Lupus nephritis (LN) is one of the most frequent and serious complications in systemic lupus erythematosus (SLE), in which antibodies affect kidney filtration. In most cases, LN diagnosis is mainly based on the renal biopsy.

Objective: The aim of this study was to evaluate the deposits of immunoglobulins and C3 in oral mucosa as a reflect marker of LN in patients with SLE.

Methodology: Incisional biopsies of oral mucosa of 20 patients were included, 17 patients with diagnosis of SLE (7 diagnosed with LN), and 3 patients with cutaneous lupus erythematosus (with no renal disease). Samples were stained using H&E and PAS, and a portion was processed by direct immunofluorescence (DIF) for the detection of IgG, M, A, and C3. Variables were analyzed and compared using the non-parametric test of Mann-Whitney. P values < 0.05 were considered statistically significant.

Results: All patients in the study were female. Oral mucosa proved the presence of immunoglobulins and C3 in 71.4% of patients with LN. LN group demonstrate higher expression of IgG, M and C3 compared to other groups (p = 0.04). A band of inflammatory infiltrate and increase of basal membrane thickness were observed in oral mucosa, although absence of lesion.

Conclusion: Oral deposits of immunoglobulin G, M, and C3 are present in most patients with LN, suggesting presence of autoantibodies in oral mucosa are potential predictors of renal disease.

Keywords: Systemic Lupus Erythematosus; Lupus Nephritis; Oral Mucosa

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Citation: Villarroel-Dorrego Mariana.,et al. “Oral Mucosa Deposits of Immunoglobulins and Complement Component 3 in Patients with Lupus Nephritis”. EC Dental Science 19.10 (2020): 64-70.

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