Abstract

Technological and scientific innovations have increased exponentially over the last decade. With the continuous advancement in new research techniques, researchers continually develop breakthrough therapies by understanding the cellular and molecular base of every disease. In the process of evolution, gene therapy and molecular dentistry are driving improvements in drug development. Gene therapy has opened doors to the era of evidence-based dentistry. Studies based on the interaction between genetic and dental disorders have given new understanding of the treatment options for oral diseases. Knowledge in molecular dentistry, transcriptomes, and proteomes can assist in better control and prevention of personalized orthodontics. This review portrays the links between genetic disposition and its significant impact in the field of dentistry.

Keywords: Molecular Dentistry; Gene Therapy and Stem Cells

References

1. Frazier-Bowers SA and Vora SR. “Genetic disorders of dental development: tales from the bony crypt”. Current Osteoporosis Reports1 (2017): 9-17.
2. Abedalthagafi MS. “Precision medicine of monogenic disorders: lessons learned from the Saudi human genome”. Frontiers in Bioscience 24 (2019): 870-889.
3. Vieira AR. “Genetic Basis of Enamel and Dentin Defects”. Genetic Basis of Oral Health Conditions: Springer (2019): 9-21.
4. Ghergie M., et al. “Genes and dental disorders”. Clujul Medical 3 (2013): 196.
5. Jaedicke KM., et al. “Salivary cytokines as biomarkers of periodontal diseases”. Periodontology 2000 1 (2016): 164-183.
6. Nandini K., et al. “Genetics In Paediatric Dentistry”. Journal of Clinical Medicine Research 2 (2019): 1-6.
7. Vieira AR. “Genetic Basis of Periodontitis and Tooth Loss”. Genetic Basis of Oral Health Conditions: Springer (2019): 43-50.
8. Schafer CA., et al. “Saliva diagnostics: utilizing oral fluids to determine health status”. Saliva: Secretion and Functions 24 (2014): 88-98.
9. Koneru S and Tanikonda R. “Salivaomics-A promising future in early diagnosis of dental diseases”. Dental Research Journal1 (2014): 11.
10. Potdar PD and Jethmalani YD. “Human dental pulp stem cells: Applications in future regenerative medicine”. World Journal of Stem Cells5 (2015): 839-851.
11. Leyendecker Junior A., et al. “The use of human dental pulp stem cells for in vivo bone tissue engineering: a systematic review”. Journal of Tissue Engineering 9 (2018): 2041731417752766.
12. Luzuriaga J., et al. “Human dental pulp stem cells grown in neurogenic media differentiate into endothelial cells and promote neovasculogenesis in the mouse brain”. Frontiers in Physiology 10 (2019): 347.
13. Khandelwal A., et al. “Gene therapy and its application in dentistry”. Journal of Indian Academy of Oral Medicine and Radiology5 (2010): 37.
14. Liu Y., et al. “Facilitated vascularization and enhanced bone regeneration by manipulation hierarchical pore structure of scaffolds”. Materials Science and Engineering: C (2020): 110622.
15. Duttenhoefer F., et al. “Tissue Engineering and Cell-Based Therapy for Bone Regeneration: Clinical Application and In Vivo and In Vitro Research”. Craniomaxillofacial Reconstructive and Corrective Bone Surgery: Springer (2019): 143-153.
16. Huang S., et al. “Biomimetics using nanotechnology/nanoparticles in dental tissue regeneration”. Nanobiomaterials in Clinical Dentistry: Elsevier (2019): 495-515.
17. Vieira AR. “Genetic Basis of Tooth Agenesis, Supernumerary Teeth, and Other Dental Abnormalities”. Genetic Basis of Oral Health Conditions: Springer (2019): 23-31.
18. Thakur SN. “Implant dentistry-current trends in rehabilitation of missing teeth”. Journal of Chitwan Medical College1 (2019): 1-1.
19. Junior BRB and Echeverrigaray S. “Dentistry and molecular biology: a promising field for tooth agenesis management”. The Tohoku Journal of Experimental Medicine4 (2012): 243-249.
20. Soxman JA., et al. “Tooth Development”. Anomalies of the Developing Dentition: Springer (2019): 1-6.
21. Mendoza JMG., et al. “Determinants of oral health care related to the frequency and severity of dental caries in preschool children”. Nova Scientia22 (2019): 85-101.
22. Madhumitha M., et al. “Passive Immunization Against Streptococcus mutans”. Indian Journal of Public Health Research and Development 12 (2019): 1141-1144.
23. Pereira VB., et al. “DNA vaccines approach: from concepts to applications” (2014).
24. Sui Y., et al. “Generation of functional salivary gland tissue from human submandibular gland stem/progenitor cells”. Stem Cell Research and Therapy1 (2020): 1-13.
25. Baum BJ., et al. “Advances in salivary gland gene therapy–oral and systemic implications”. Expert Opinion on Biological Therapy 10 (2015): 1443-1454.
26. Romero-Reyes M and Uyanik JM. “Orofacial pain management: current perspectives”. Journal of Pain Research 7 (2014): 99.
27. Dubner R. “Emerging research on orofacial pain”. SAGE Publications Sage CA: Los Angeles, CA (2016).
28. Guedon J-MG., et al. “Current gene therapy using viral vectors for chronic pain”. Molecular Pain 11 (2015): s12990-12015.
29. Wang D., et al. “Adeno-associated virus vector as a platform for gene therapy delivery”. Nature Reviews Drug Discovery5 (2019): 358-378.
30. Glorioso III JC., et al. “Non-toxic HSV vectors for efficient gene delivery applications and complementing cells for their production”. Google Patents (2019).
31. Rubin JD., et al. “Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections”. Human Gene Therapy12 (2019): 1559-1571.
32. Sung Y and Kim S. “Recent advances in the development of gene delivery systems”. Biomaterials Research 1 (2019): 8.
33. Yin H., et al. “Non-viral vectors for gene-based therapy”. Nature Reviews Genetics8 (2014): 541-555.
34. Hinohara K and Polyak K. “Intratumoral heterogeneity: more than just mutations”. Trends in Cell Biology (2019).
35. Düzgüneş N., et al. “Suicide gene therapy of oral squamous cell carcinoma and cervical carcinoma in vitro”. Suicide Gene Therapy: Springer (2019): 177-184.
36. Duzgunes N., et al. “Suicide Gene Therapy of Oral Squamous Cell Carcinoma and Cervical Carcinoma In Vitro”. Methods in Molecular Biology 1895 (2019): 177-184.
37. Goswami R., et al. “Gene Therapy Leaves a Vicious Cycle”. Frontiers in Oncology 9 (2019): 297.
38. Li L., et al. “Comprehensive immunogenomic landscape analysis of prognosis-related genes in head and neck cancer”. Scientific Reports1 (2020): 6395.
39. Farmer ZL., et al. “Gene Therapy in Head and Neck Cancer”. Oral and Maxillofacial Surgery Clinics of North America1 (2019): 117-124.
40. Bali A., et al. “An overview of gene therapy in head and neck cancer”. Indian Journal of Human Genetics3 (2013): 282-290.
41. Westover L., et al. “Non-invasive evaluation of periodontal ligament stiffness during orthodontic tooth movement”. The Angle Orthodontist 2 (2019): 228-234.
42. Chang JH., et al. “Injectable RANKL sustained release formulations to accelerate orthodontic tooth movement”. European Journal of Orthodontics (2019).
43. Li C., et al. “Local injection of RANKL facilitates tooth movement and alveolar bone remodelling”. Oral Diseases2 (2019): 550-560.
44. Kaya S., et al. “Effects of orthodontic force magnitude on cell apoptosis and RANKL-induced osteoclastogenesis: Studies in a rat model”. Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie: Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2 (2020): 100-112.