Review Article
Volume 19 Issue 7 - 2020
Overview of Different Options for Dental Pulp Therapy: A Systematic Review
Hatem Faisal Bajnaid1*, Rayif Jazaa Alanazi2, Nouf Saad Suliman3, Saad Saleh Alamri4, Eman Ali Alhabib4, Nouf Naif Alquthami5, Ranad Abdulkareem Alghamdi6, Duaa Hamed Alrajhi6, Naif Awdhah Alzahrani7, Nujud Awadh Alharbi8 and Fatimah Mohammad Alamri9
1Department of Endodontics, King Fahad Hospital, Jeddah, Saudi Arabia
2Department Dentistry, Ajmal Dental Polylinic, Hail, Saudi Arabia
3College of Dentistry, King Khalid University, Abha, Saudi Arabia
4General Dentist, Ministry of Health, Hail, Saudi Arabia
5College of Dentistry, Alfarabi Colleges, Jeddah, Saudi Arabia
6General Dentist, Andalusia Dental Center, Jeddah, Saudi Arabia
7General Dentist, Albaha University Medical Center, Albaha, Saudi Arabia
8College of Dentistry, King Saud University, Riyadh, Saudi Arabia
9College of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
*Corresponding Author: Hatem Faisal Bajnaid, Department of Endodontics, King Fahad Hospital, Jeddah, Saudi Arabia.
Received:June 16, 2020; Published: June 29, 2020




Abstract

The dental pulp has many functions that include nutritive, protective, initiative, and reparative ones. Nevertheless, it has a low threshold of damage, for being enclosed in hard tissue. This could, by time, lead to a loss of the pulp and fragile teeth with low quality of life. To avoid tooth extraction and all of the root canal treatment, the proper pulp capping or regeneration therapy of the pulp should be directly carried out. For that, this systematic review will focus on the different options of dental pulp therapy. A systematic electronic database search was conducted for relevant studies published from inception and till 13th May 2020 in seven databases. We included the most appropriate published studies that reported different techniques of dental pulp therapy, after excluding irrelevant ones and those with poor quality. Therapies for dental pulp include two main categories: direct pulp capping and vital pulp amputation. In this study, we have reviewed current and future dental pulp therapies. Most of the current procedures cause an irreversible sacrifice of tissues, leaving vulnerable teeth. Shortly, new regenerative therapies and DCP agents, thanks to the great ongoing studies, are expected to re-shape the current practice and improve patients’ quality of life.

Keywords: Dental Pulp Therapy; Endodontics; Pulpotomy

References

  1. Avery James K and Daniel J Chiego. “Essentials of Oral Histology and Embryology: A Clinical Approach”. St. Louis, Mo.: Mosby Elsevier (2006).
  2. Hargreaves Kenneth M., et al. “Seltzer and Bender's Dental Pulp”. Quintessence Chicago (2012).
  3. Bergenholtz Gunnar., et al. “Textbook of Endodontology”. John Wiley and Sons (2013).
  4. Heyeraas KJ and I Kvinnsland. "Tissue Pressure and Blood Flow in Pulpal Inflammation”. Proceedings of the Finnish Dental Society 1 (1992): 393-401.
  5. Ng YL., et al. "Outcome of Secondary Root Canal Treatment: A Systematic Review of the Literature”. International Endodontic Journal 12 (2008): 1026-1046.
  6. Health, National Institutes of. "Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies”. National Heart, Lung, and Blood Institute (2014).
  7. Komabayashi T., et al. "Current Status of Direct Pulp-Capping Materials for Permanent Teeth”. Dental Materials Journal 1 (2016): 1-12.
  8. Morotomi Takahiko., et al. "Current and Future Options for Dental Pulp Therapy”. The Japanese Dental Science Review1 (2019): 5-11.
  9. Hilton Thomas J. "Keys to Clinical Success with Pulp Capping: A Review of the Literature”. Operative Dentistry5 (2009): 615-625.
  10. Chen L., et al. "Bioactive Dental Restorative Materials: A Review”. American Journal of Dentistry 4 (2013): 219-227.
  11. Poggio C., et al. "In Vitro Cytotoxicity Evaluation of Different Pulp Capping Materials: A Comparative Study”. Archives of Industrial Hygiene and Toxicology 3 (2015): 181-188.
  12. Reston EG and CA De Souza Costa. "Scanning Electron Microscopy Evaluation of the Hard Tissue Barrier after Pulp Capping with Calcium Hydroxide, Mineral Trioxide Aggregate (Mta) or Proroot Mta”. Australian Endodontic Journal 2 (2009): 78-84.
  13. De Lourdes Rodrigues Accorinte, M., et al. "Influence of Rubber Dam Isolation on Human Pulp Responses after Capping with Calcium Hydroxide and an Adhesive System”. Quintessence International 37.3 (2006): 205-212.
  14. De Souza Costa CA., et al. "Response of Human Pulps Capped with a Self-Etching Adhesive System”. Dental Materials 3 (2001): 230-240.
  15. Accorinte ML., et al. "Response of Human Pulps Capped with Different Self-Etch Adhesive Systems”. Clinical Oral Investigations 2 (2008): 119-127.
  16. Sübay RK and M Demirci. "Pulp Tissue Reactions to a Dentin Bonding Agent as a Direct Capping Agent”. Journal of Endodontics 3 (2005): 201-204.
  17. Accorinte Mde L., et al. "Adverse Effects of Human Pulps after Direct Pulp Capping with the Different Components from a Total-Etch, Three-Step Adhesive System”. Dental Materials 7 (2005): 599-607.
  18. Fernandes AM., et al. "Direct Capping of Human Pulps with a Dentin Bonding System and Calcium Hydroxide: An Immunohistochemical Analysis”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 3 (2008): 385-390.
  19. Hörsted-Bindslev P., et al. "Direct Capping of Human Pulps with a Dentin Bonding System or with Calcium Hydroxide Cement”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 5 (2003): 591-600.
  20. Jitaru S., et al. "The Use of Bioceramics in Endodontics - Literature Review”. Clujul Medical 4 (2016): 470-473.
  21. Camilleri J. "The Chemical Composition of Mineral Trioxide Aggregate”. Journal of Conservative Dentistry 4 (2008): 141-143.
  22. Bogen G., et al. "Direct Pulp Capping with Mineral Trioxide Aggregate: An Observational Study”. Journal of the American Dental Association3 (2008): 305-315.
  23. Mente, J., et al. "Treatment Outcome of Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: Long-Term Results”. Journal of Endodontics 11 (2014): 1746-1751.
  24. Hilton TJ., et al. "Comparison of Caoh with Mta for Direct Pulp Capping: A Pbrn Randomized Clinical Trial”. Journal of Dental Research 7(2013): 16s-22s.
  25. Al-Hiyasat AS., et al. "The Radiographic Outcomes of Direct Pulp-Capping Procedures Performed by Dental Students: A Retrospective Study”. Journal of the American Dental Association12 (2006): 1699-1705.
  26. Torabinejad M., et al. "Physical and Chemical Properties of a New Root-End Filling Material”. Journal of Endodontics 7 (1995): 349-353.
  27. Monteiro Bramante C., et al. "Presence of Arsenic in Different Types of Mta and White and Gray Portland Cement”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 6 (2008): 909-913.
  28. Camilleri J. "Characterization and Chemical Activity of Portland Cement and Two Experimental Cements with Potential for Use in Dentistry”. International Endodontic Journal 9 (2008): 791-799.
  29. Accorinte Mde L., et al. "Evaluation of Mineral Trioxide Aggregate and Calcium Hydroxide Cement as Pulp-Capping Agents in Human Teeth”. Journal of Endodontics 1 (2008): 1-6.
  30. Tuna D and A Olmez. "Clinical Long-Term Evaluation of Mta as a Direct Pulp Capping Material in Primary Teeth”. International Endodontic Journal 4 (2008): 273-278.
  31. Aeinehchi M., et al. "Mineral Trioxide Aggregate (Mta) and Calcium Hydroxide as Pulp-Capping Agents in Human Teeth: A Preliminary Report”. International Endodontic Journal 3 (2003): 225-231.
  32. Iwamoto CE., et al. "Clinical and Histological Evaluation of White Proroot Mta in Direct Pulp Capping”. American Journal of Dentistry 2 (2006): 85-90.
  33. Min KS., et al. "Effect of Mineral Trioxide Aggregate on Dentin Bridge Formation and Expression of Dentin Sialoprotein and Heme Oxygenase-1 in Human Dental Pulp”. Journal of Endodontics 6 (2008): 666-670.
  34. Qudeimat MA., et al. "Calcium Hydroxide Vs Mineral Trioxide Aggregates for Partial Pulpotomy of Permanent Molars with Deep Caries”. European Archives of Paediatric Dentistry 2 (2007): 99-104.
  35. Percinoto C., et al. "Clinical and Radiographic Evaluation of Pulpotomies Employing Calcium Hydroxide and Trioxide Mineral Aggregate”. General Dentistry 4 (2006): 258-261.
  36. Nair PN., et al. "Histological, Ultrastructural and Quantitative Investigations on the Response of Healthy Human Pulps to Experimental Capping with Mineral Trioxide Aggregate: A Randomized Controlled Trial”. International Endodontic Journal 2 (2008): 128-150.
  37. Chacko V and S Kurikose. "Human Pulpal Response to Mineral Trioxide Aggregate (Mta): A Histologic Study”. The Journal of Clinical Pediatric Dentistry 3 (2006): 203-209.
  38. Formosa LM., et al. "The Effect of Curing Conditions on the Physical Properties of Tricalcium Silicate Cement for Use as a Dental Biomaterial”. International Endodontic Journal 4 (2012): 326-336.
  39. Bortoluzzi EA., et al. "The Influence of Calcium Chloride on the Setting Time, Solubility, Disintegration, and Ph of Mineral Trioxide Aggregate and White Portland Cement with a Radiopacifier”. Journal of Endodontics 4 (2009): 550-554.
  40. Nielsen MJ., et al. "Mechanical Properties of New Dental Pulp-Capping Materials”. General Dentistry 1 (2016): 44-48.
  41. Hench LL. "The Story of Bioglass”. Journal of Materials Science: Materials in Medicine 11 (2006): 967-978.
  42. Pereira RDS., et al. "Histomorphometric and Immunohistochemical Assessment of Runx2 and Vegf of Biogran™ and Autogenous Bone Graft in Human Maxillary Sinus Bone Augmentation: A Prospective and Randomized Study”. Clinical Implant Dentistry and Related Research 5 (2017): 867-875.
  43. Washio A., et al. "Physicochemical Properties of Newly Developed Bioactive Glass Cement and Its Effects on Various Cells”. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2 (2015): 373-380.
  44. Hanada K., et al. "In Vitro and in Vivo Effects of a Novel Bioactive Glass-Based Cement Used as a Direct Pulp Capping Agent”. Journal of Biomedical Materials Research Part B: Applied Biomaterials 1 (2019): 161-168.
  45. McKay WF., et al. "A Comprehensive Clinical Review of Recombinant Human Bone Morphogenetic Protein-2 (Infuse Bone Graft)”. International Orthopaedics6 (2007): 729-734.
  46. Qin C., et al. "Dentin Matrix Protein 1 (Dmp1): New and Important Roles for Biomineralization and Phosphate Homeostasis”. Journal of Dental Research 12 (2007): 1134-1141.
  47. Washio A., et al. "Possible Involvement of Smad Signaling Pathways in Induction of Odontoblastic Properties in Kn-3 Cells by Bone Morphogenetic Protein-2: A Growth Factor to Induce Dentin Regeneration”. International Journal of Dentistry (2012): 258469.
  48. Aberg T., et al. "Expression Patterns of Bone Morphogenetic Proteins (Bmps) in the Developing Mouse Tooth Suggest Roles in Morphogenesis and Cell Differentiation”. Developmental Dynamics 4 (1997): 383-396.
  49. Shimabukuro Y., et al. "Fibroblast Growth Factor-2 Regulates the Cell Function of Human Dental Pulp Cells”. Journal of Endodontics 11 (2009): 1529-1535.
  50. Morotomi T., et al. "Continuous Fever-Range Heat Stress Induces Thermotolerance in Odontoblast-Lineage Cells”. Archives of Oral Biology 7 (2014): 741-748.
  51. Lanneau D., et al. "Apoptosis Versus Cell Differentiation: Role of Heat Shock Proteins Hsp 90, Hsp70 and Hsp27”. Prion 1 (2007): 53-60.
  52. Nakayama K., et al. "The Novel Nf-Κb Inhibitor, Mti-Ii Peptide Anti-Inflammatory Drug, Suppresses Inflammatory Responses in Odontoblast-Like Cells”. Journal of Cellular Biochemistry11 (2016): 2552-2558.
  53. Kalyan Ksdr., et al. "Preclinical Evaluation and Clinical Trial of Chlorhexidine Polymer Scaffold for Vital Pulp Therapy”. The Journal of Clinical Pediatric Dentistry 2 (2019): 109-115.
  54. Durmus N., et al. "Effectiveness of the Ozone Application in Two-Visit Indirect Pulp Therapy of Permanent Molars with Deep Carious Lesion: A Randomized Clinical Trial”. Clinical Oral Investigations 10 (2019): 3789-3799.
  55. Discher DE., et al. "Growth Factors, Matrices, and Forces Combine and Control Stem Cells”. Science5935 (2009): 1673-1677.
  56. Nakashima M. "Induction of Dentine in Amputated Pulp of Dogs by Recombinant Human Bone Morphogenetic Proteins-2 and -4 with Collagen Matrix”. Archives of Oral Biology 12 (1994): 1085-1089.
  57. Yeom KH., et al. "Platelet-Rich Plasma Enhances the Differentiation of Dental Pulp Progenitor Cells into Odontoblasts”. International Endodontic Journal 3 (2016): 271-278.
  58. Sheridan MH., et al. "Bioabsorbable Polymer Scaffolds for Tissue Engineering Capable of Sustained Growth Factor Delivery”. Journal of Controlled Release 1-3 (2000): 91-102.
  59. Julovi SM., et al. "Hyaluronan Inhibits Il-1beta-Stimulated Collagenase Production Via Down-Regulation of Phosphorylated P38 in Sw-1353 Human Chondrosarcoma Cells”. Modern Rheumatology 3 (2008): 263-270.
  60. Inuyama Y., et al. "Effects of Hyaluronic Acid Sponge as a Scaffold on Odontoblastic Cell Line and Amputated Dental Pulp”. Journal of Biomedical Materials Research Part B: Applied Biomaterials 1 (2010): 120-128.
Citation: Hatem Faisal Bajnaid., et al. “Overview of Different Options for Dental Pulp Therapy: A Systematic Review”. EC Dental Science 19.7 (2020): 100-109.

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