Research Article
Volume 19 Issue 7 - 2020
Clinico-Biochemical Evaluation of CRP and Complete Blood Count in Chronic Periodontitis
Kamalkishor Mankar1 and Pranjali Bawankar2*
1Reader, Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Nagpur, India
2Senior Lecturer, Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Nagpur, India
*Corresponding Author: Pranjali Bawankar, Senior Lecturer, Department of Periodontics, VSPM Dental College and Research Centre, Nagpur, India.
Received: March 23, 2020; Published: June 02, 2020




Abstract

Introduction: A strong association of chronic periodontal disease and cardiovascular disorders has been established. The interlink being chronic inflammation. Serum levels of CRP have been shown to be a strong predictor of the risk of cardiovascular events. The relation of anemia and chronic inflammatory diseases has been reported. In light of the above-mentioned facts the present study was formulated to evaluate serum levels of CRP, Hb% WBC count and RBC count in patients with chronic periodontitis.

Objective: To compare and correlate the serum levels of C-reactive protein and WBC, RBC, Hb% in patients with chronic periodontitis and healthy controls.

Material and Methods: A total of 120 patients equally divided into four groups depending upon the severity of chronic periodontitis (CP) were recruited for the study. The serum levels of C-reactive protein were assessed using Enzyme Linked Immunosorbant Assay. The complete blood count including WBC, RBC, Hb% was obtained using CBC cell counter.

Results: The serum CRP and WBC levels were found to be elevated in severe CP patients as compared to moderate and mild CP patients. The RBC count and Hb % was found to be lowered in severe CP as compared to other groups.

Conclusion: Within the limitations of the study it can be conclude that the serum CRP levels increases with the severity of periodontal disease The WBC count also was found to be increased in severe chronic periodontitis cases thereby suggesting active inflammation. Whereas the RBC count and Hb count significantly decreases with the severity of periodontitis thereby increasing risk of anemia.

Keywords: Chronic Periodontitis; Cardiovascular Diseases; Anemia; Inflammation; Periodontal Disease

References

  1. Genco Goldman H and Cohen D. “Contemporary Periodontics”. Saint Louis: The CV Mosby Company (1990): 184-194.
  2. Haziout A., et al. “Cutting edge: The induction of acute phase proteins by lipopolysaccharide uses a novel pathway that is CD14 independent”. Journal of Immunology 160 (1998): 2570-2572.
  3. Nieto FJ. “Infections and atherosclerosis: new clues from an old hypothesis?” American Journal of Epidemiology 148 (1998): 937-948.
  4. Ross R. “Atherosclerosis: an inflammatory disease”. The New England Journal of Medicine 340.2 (1999): 115-126.
  5. Koening W. “Heart disease and inflammatory response”. British Medical Journal 321.7255 (2000): 187-188.
  6. Libby P. “Inflammation in atherosclerosis”. Nature 420 (2002): 868-874.
  7. Mehta JL., et al. “Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease”. Journal of the American College of Cardiology 3 (1998): 1217-1225.
  8. Slade DG., et al. “Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study”. Archives of Internal Medicine 163 (2003): 1172-1179.
  9. Ridker PM., et al. “C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women”. The New England Journal of Medicine 342 (2000): 836-843.
  10. Brown DW., et al. “Hematocrit and the risk of coronary heart disease mortality”. American Heart Journal 142 (2001): 657-663.
  11. Sweetnam PM., et al. “Total and differential leukocyte counts as predictors of ischemic heart disease: the Caerphilly and Speedwell studies”. American Journal of Epidemiology 145 (1997): 416-421.
  12. Manttari M., et al. “Leukocytes as a coronary risk factor in a dyslipidemic male population”. American Heart Journal 123 (1992): 873-877.
  13. Heinrich PC., et al. “Interleukin-6 and the acute phase response”. Biochemical Journal 265 (1990): 621-636.
  14. Ernst E., et al. “Leukocytes and the risk of ischemic diseases”. The Journal of the American Medical Association 257 (1987): 2318-2324.
  15. Danesh J., et al. “Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. Meta- analysis of prospective studies”. The Journal of the American Medical Association 279 (1998): 1477-1482.
  16. Hutter JW., et al. “Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects”. Journal of Clinical Periodontology 28 (2001): 930-936.
  17. Ridker PM., et al. “Established and emerging plasma biomarkers in the prediction of atherothrombotic events”. Circulation 109.25-1 (2004): IV6-IV19.
  18. Noack B., et al. “Periodontal infections contribute to elevated systemic C reactive protein level”. Journal of Periodontology 72 (2001): 1221-1227.
  19. Glurich I., et al. “Systemic inflammation in cardiovascular and periodontal disease: comparative study”. Clinical and Diagnostic Laboratory Immunology 9 (2002): 425-432.
  20. Pepys MB and Baltz ML. “Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein”. Advances in Immunology 34 (1983): 141-212.
  21. Slade DG., et al. “Acute phase inflammatory response to periodontal disease in the US population”. Journal of Dental Research 79 (2000): 49-57. 
  22. Kweider M., et al. “Dental disease, fibrinogen and white cell count; links with myocardial infarction?” Scottish Medical Journal 38 (1993): 73-74.
  23. Hutter JW., et al. “Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects”. Journal of Clinical Periodontology 28 (2001): 930-936.
  24. Vreugdenhil DM., et al. “Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease”. Journal of Clinical Investigation 91 (1993): 1351-1357.
  25. Jongen-Lavrencic M., et al. “Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease”. The Journal of Rheumatology 24 (1997): 1504-1509.
  26. Katevas P., et al. “Peripheral blood mononuclear cells from patients with rheumatoid arthritis suppress erythropoiesis In vitro via the production of tumor necrosis factor alpha”. European Journal of Haematology 53 (1994): 26-30.
Citation: Kamalkishor Mankar and Pranjali Bawankar. “Clinico-Biochemical Evaluation of CRP and Complete Blood Count in Chronic Periodontitis”. EC Dental Science 19.7 (2020): 04-12.

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