Case Report
Volume 19 Issue 4 - 2020
Oro-Dental Manifestations in Patients with Acromegaly: A Case Report
Reva Bembi1*, Esha Garg2, Neha Vaid3, Arpit Sikri4 and Jyotsana Sikri5
1Senior Lecturer, Department of Oral Medicine and Radiology, JCD Dental College, Sirsa, Haryana, India
2Consultant Oral and Maxillofacial Radiologist, India
3Senior Lecturer, Department of Oral Pathology, JCD Dental College, Sirsa, Haryana, India
4Senior Resident, Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, New Delhi, India
5Senior Lecturer, Department of Conservative Dentistry and Endodontics, Santosh Dental College, Santosh Deemed to be University, Ghaziabad, Delhi NCR, India
*Corresponding Author: Reva Bembi, Senior Lecturer, Department of Oral Medicine and Radiology, JCD Dental College, Sirsa, Haryana, India.
Received: January 27, 2020; Published: March 19, 2020


Acromegaly is an acquired disorder related to excessive production of growth hormone and characterized by progressive somatic disfigurement (mainly involving face and extremities) and systemic manifestations. It is a rare condition, with an estimated prevalence of around 60 per million and an annual incidence of 3 - 4 per million. Analyzing mortality determinants, around 60% of acromegalic patients die from cardiovascular disease, 25% from respiratory causes and 15% from neoplasia. It has tendency towards Mandibular overgrowth, tooth separation and jaw malocclusion which makes its diagnosis important even for dentists.

Keywords: Acromegaly; Dysmorphic Syndrome


  1. de Herder WW. “Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886)”. Pituitary 12.3 (2009): 236-244.
  2. Melmed S. “Acromegaly pathogenesis and treatment”. Journal of Clinical Investigation 119.11 (2009): 3189-3202.
  3. de Herder WW. “The History of Acromegaly”. Neuroendocrinology 103.1 (2016): 7-17.
  4. Mammis A., et al. “Early descriptions of acromegaly and gigantism and their historical evolution as clinical entities”. Neurosurgery Focus 29.4 (2010): E1.
  5. Chanson P and Salenave S. “Acromegaly”. Orphanet Journal of Rare Diseases 3 (2008): 17.
  6. Drange MR., et al. “Pituitary tumor registry: a novel clinical resource”. Journal of Clinical Endocrinology and Metabolism 85.1 (2000): 168-174.
  7. Kamenicky P., et al. “Body Fluid Expansion in Acromegaly Is Related to Enhanced Epithelial Sodium Channel (ENaC) Activity”. The Journal of Clinical Endocrinology and Metabolism 96.7 (2011): 2127-2135.
  8. Molitch ME. “Clinical manifestations of acromegaly”. Endocrinology and Metabolism Clinics of North America 21.3 (1992): 597-614.
  9. Kashyap RR., et al. “Dental patient with acromegaly: a case report”. Journal of Oral Science 53.1 (2011): 133-136.
  10. White SC and Pharaoh MJ. “Oral Radiology. Principles and interpretation”. 6th Edition, Elsevier, St Louis (2009): 458-460.
  11. Killinger Z., et al. “Arthropathy in acromegaly”. Rheumatic Disease Clinics of North America 36.4 (2010): 713-720.
  12. Scarpa R., et al. “Acromegalic axial arthropathy: a clinical case-control study”. Journal of Clinical Endocrinology and Metabolism 89.2 (2004): 598-603.
  13. Lugo G., et al. “Clinical Manifestations and Diagnosis of Acromegaly”. International Journal of Endocrinology (2012): 540398.
  14. Colao A., et al. “Systemic Hypertension and Impaired Glucose Tolerance Are Independently Correlated to the Severity of the Acromegalic Cardiomyopathy”. The Journal of Clinical Endocrinology and Metabolism 85.1 (2000): 193-199.
  15. Wassenaar MJ., et al. “Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study”. Journal of Clinical Endocrinology and Metabolism 95.5 (2010): 2073-2079.
  16. Chanson P., et al. “McCune-Albright syndrome in adulthood”. Pediatric Endocrinology Reviews 4.4 (2007): 453-462.
  17. Vergès B., et al. “Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study”. Journal of Clinical Endocrinology and Metabolism 87.2 (2002): 457-465.
  18. Bertherat J. “Carney complex (CNC)”. Orphanet Journal of Rare Diseases 1 (2006): 21.
  19. Vierimaa O., et al. “Pituitary Adenoma Predisposition Caused by Germline Mutations in the AIP Gene”. Science 312.5777 (2006): 1228-1230.
  20. Melmed S., et al. “Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor”. New England Journal of Medicine 312.1 (1985): 9-17.
  21. Kumar SS., et al. “Current therapy and drug pipeline for the treatment of patients with acromegaly”. Advances in Therapy 26.4 (2009): 383-403.
  22. Laws ER. “Surgery for acromegaly: evolution of the techniques and outcomes”. Reviews in Endocrine and Metabolic Disorders 9.1 (2008): 67-70.
  23. Duymuş ZK and Karaalioglu OF. “Prosthetic restoration of a patient with acromegaly- a case report”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 19.1 (2009): 41-46.
Citation: Reva Bembi., et al. “Oro-Dental Manifestations in Patients with Acromegaly: A Case Report”. EC Dental Science 19.4 (2020): 99-106.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

January Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 10, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.