Case Report
Volume 19 Issue 3 - 2020
Lip Swelling in a Pediatric Patient: A Case Report and Literature Review
Shahla Kakoei1, Sara Amanpour2, Ali Salari3 and Sahar Mafi4*
1Oral and Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran
2Assistant Professor of Oral and Maxillofacial Pathology, School of Dentistry, Kerman, Iran
3Oral Medicine Specialist, Rafsanjan, Iran
4Postgraduate Student of Oral Medicine Department, Kerman University of Medical Sciences, Kerman, Iran
*Corresponding Author: Sahar Mafi, Postgraduate Student of Oral Medicine Department, Kerman University of Medical Sciences, Kerman, Iran.
Received: January 09, 2020; Published: February 26, 2020


Introduction: Lip enlargement is one of the most challenging problems encountered by physicians and dentists due to the various predisposing factors that are involved. 

Case Presentation: Here we report a rare case of recurrent enlargement of both upper and lower lips in a 6-year-old child. The parents reported the presence of recurrent white lesions in the patient’s oral cavity since birth. The patient’s medical history revealed no known systemic condition and use of any medications. In extraoral examination upper and lower lip enlargement was visible. Incisional biopsy was done and microscopic examination demonstrate. severe mixed inflammatory cell infiltration and numerous eosinophils are scattered in the superficial connective tissue within chronic fungal infection. 

Discussion: Candidiasis infection was considered as etiology of lip swelling and patient underwent treatment with systemic antifungal agent, which resulted in complete resolution of the condition. Due to high prevalence of chronic Candida infections, this medical condition should be considered in the differential diagnosis of lip enlargement cases.

Keywords: Lip Swelling; Lip Enlargement; Chronic Candidiasis Infection; Yeast; Allergic Reaction


  1. Lakhani Sonam., et al. "Recurrent Lip Swelling: A Diagnostic Challenge”. BMJ Case Reports (2014): bcr2013203018. 
  2. Lalla Rajesh V., et al. "Oral Candidiasis: Pathogenesis, Clinical Presentation, Diagnosis and Treatment Strategies”. Journal of the California Dental Association 41.4 (2013): 263-268. 
  3. Patil Shankargouda., et al. "Clinical Appearance of Oral Candida Infection and Therapeutic Strategies”. Frontiers in Microbiology 6 (2015): 1391. 
  4. Daley Tom D and Adytia K Gupta. "Exfoliative Cheilitis”. Journal of Oral Pathology and Medicine 24.4 (1995): 177-179. 
  5. Terai H and M Shimahara. "Cheilitis as a Variation of Candida‐Associated Lesions”. Oral Diseases 12.3 (2006): 349-352. 
  6. Critchlow William Austin and David Chang. "Cheilitis Granulomatosa: A Review”. Head and Neck Pathology 8.2 (2014): 209-213. 
  7. James D Geraint. "A Clinicopathological Classification of Granulomatous Disorders”. Postgraduate Medical Journal 76.898 (2000): 457-465. 
  8. Nikoo A., et al. "Persistent Lip Enlargement: An Unusual Presentation of Lupus Erythematosus”. International Journal of Women's Dermatology 3.2 (2017): 96-99. 
  9. Vibhute Nupura A., et al. "Cheilitis Granulomatosa: A Case Report with Review of Literature”. Indian Journal of Dermatology 58.3 (2013): 242. 
  10. Darwazeh Azmi MG and Tamer A Darwazeh. "What Makes Oral Candidiasis Recurrent Infection? A Clinical View”. Journal of Mycology (2014): 758394. 
  11. Dessinioti C and A Katsambas. "Seborrheic Dermatitis: Etiology, Risk Factors, and Treatments: Facts and Controversies”. Clinics in Dermatology 31.4 (2013): 343-351. 
  12. Bernstein Jonathan A and Luqman Seidu. "Chronic Vulvovaginal Candida Hypersensitivity: An Underrecognized and Undertreated Disorder by Allergists”. Allergy and Rhinology 6.1 (2015): e44. 
Citation: Sahar Mafi., et al. “Lip Swelling in a Pediatric Patient: A Case Report and Literature Review”. EC Dental Science 19.3 (2020): 01-06.

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