Research Article
Volume 19 Issue 2 - 2020
Comparative Evaluation of Using Leukocyte-Platelet Rich Fibrin (L-PRF) and Emdogain (EMD) in Guided Tissue Regeneration (GTR) Technique for Reconstruction of Periodontal Intrabony Defects in Patients with Periodontitis
Janet Moradi Haghgou, Erfan Abbasi Atibeh, Alireza Zamani, Ghodratollah Roshanaei and Nazli Rabienejad*
Department of Periodontology, Hamadan University of Medical Sciences, Iran
*Corresponding Author: Nazli Rabienejad, Department of Periodontology, Hamadan University of Medical Sciences, Iran.
Received: November 11, 2019; Published: January 29, 2020


Background: Positive results of using GTR technique for reconstruction of intrabony defects which have been proven in many studies. Aim of this study was to evaluate the effect of using L-PRF and EMD growth factors along with GTR technique for reconstruction of periodontal intrabony defects.

Methods and Materials: Forty five intrabony defects resulted from periodontal disease which can be reconstructed were enrolled in the study. Defects divided into three groups by simple sampling (n = 15). Group 1 just got GTR treatment as control group, group 2 got L-PRF along with GTR treatment and in group 3 EMD used along with GTR. Clinical factors such as periodontal probing depth (PPD), clinical attachment level (CAL), keratinized gingival width (KGW) and bleeding on probing (BOP) were evaluated before and six months after treatment. Also amount of bone fill was evaluated with standard radiography.

Result: Treatment in all three groups significantly result in reduction of PPD and gaining of CAL. Sites with BOP significantly decreased, defects significantly filled with bone, however, there was no significant difference in KGW. Intragroup comparison showed no significant difference among groups in evaluated factors. But the most PPD reduction was 4.5 ± 1 in L-PRF+GTR group, the most CAL gain was 3.73 ± 2 in GTR group, the most reduction in BOP sites were 14 sites in L-PRF+GTR groups and the most bone fill was 73% in GTR group.

Conclusion: Using EMD or L-PRF along GTR treatment does not have additional effect on positive results of GTR treatment alone.

Keywords: GTR; L-PRF; EMD; Periodontal Probing Depth; Clinical Attachment Level


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Citation: Nazli Rabienejad., et al. “Comparative Evaluation of Using Leukocyte-Platelet Rich Fibrin (L-PRF) and Emdogain (EMD) in Guided Tissue Regeneration (GTR) Technique for Reconstruction of Periodontal Intrabony Defects in Patients with Periodontitis”. EC Dental Science 19.2 (2020): 01-07.

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