Research Article
Volume 19 Issue 2 - 2020
Oral Lichen Planus and Aloe Vera
Aina Torrejon Moya1, Albert Estrugo-Devesa2*, Enric Jané-Salas2, Antonio Marí Roig3 and José López-López4*
1Master’s Student in Oral Medicine, Surgery and Implantology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain
2Specialist in Stomatology, Professor of Oral Pathology, Faculty of Medicine and Health Sciences (Dentistry) and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, Spain
3Head of Service of Department of Maxillofacial Surgery, University Hospital of Bellvitge and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL and Professor of the Department of Clinical Sciences, Faculty of Medicine and Health Sciences (Medicine), University of Barcelona, Spain
4Specialist in Stomatology, Professor of Oral Pathology, Faculty of Medicine and Health Sciences (Dentistry) and Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL and Medical Director and Head of Service of the Surgical Medical Area of Odontological Hospital, University of Barcelona, Spain
*Corresponding Author: José López López and Albert Estrugo Devesa, Department of Odontostomatology, Faculty of Medicine and Health Sciences, Barcelona, Spain.
Received: January 07, 2020; Published: January 29, 2020


Objective: The aim of this review was to gather the available evidence regarding aloe vera treatment with oral lichen plans patients. 

This systematic review was conducts to answer the question: “When treating oral lichen planus patients, is aloe Vera an effective treatment versus other treatments?”.

Materials and Methods: A systematic review of the literature was done following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements. An electronic research was carried out using different electronic databases, PubMed and Cochrane databases.

Results: The searches in both databases (PubMed and Cochrane) resulted in 6 articles, one duplicated article was found and only four of them were eligible.

Manual research of the reference list yielded no additional papers. 

Therefore, four articles were identified as eligible for inclusion in this review, according to its inclusion and exclusion criteria. All the four studies were randomized clinical trials (RCT).

Conclusion: The results of the four RCTs showed an effective treatment to manage OLP patients, although corticosteroids are the gold standard, the treatment with AV shows encouraging results without adverse effects. 

Keywords: Aloe Vera; Oral Lichen Planus; Lichen Planus; Treatment; Management


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  2. Ismail Sumairi B., et al. "Oral Lichen Planus And Lichenoid Reactions: Etiopathogenesis, Diagnosis, Management And Malignant Transformation”. Journal of Oral Science 49.2 (2007): 89-106. 
  3. Farhi David and Nicolas Dupin. "Pathophysiology, Etiologic Factors, And Clinical Management Of Oral Lichen Planus, Part I: Facts And Controversies”. Clinics in Dermatology 28.1 (2010): 100-108. 
  4. López López José and Roselló Llabrés, Xavier “Cyclosporine A, an alternative to the oral lichen planus erosive treatment”. Bulletin du Groupèment International Pour La Recherche Scientifique en Stomatologie AND Odontology 38.1-2 (1995): 33-38. 
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  7. Mangaiyarkarasi SP., et al. "Benefits Of Aloe Vera In Dentistry”. Journal of Pharmacy and Bioallied Sciences 7.5 (2015): 257. 
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  12. Reddy RL et al. “Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus”. Quintessence International 43.9 (2012) 793-800. 
  13. Choonhakarn C., et al. "The Efficacy Of Aloe Vera Gel In The Treatment Of Oral Lichen Planus: A Randomized Controlled Trial”. British Journal of Dermatology 158.3 (2007): 573-577. 
  14. Mansourian Arash., et al. "Comparison Of Aloe Vera Mouthwash With Triamcinolone Acetonide 0.1% On Oral Lichen Planus: A Randomized Double-Blinded Clinical Trial”. The American Journal of the Medical Sciences 342.6 (2011): 447-451. 
  15. Ahmadi Amirhossein. "Potential Prevention: Aloe Vera Mouthwash May Reduce Radiation-Induced Oral Mucositis In Head And Neck Cancer Patients”. Chinese Journal of Integrative Medicine 18.8 (2012): 635-640. 
  16. Al-Maweri Sadeq Ali., et al. "Aloe Vera In Treatment Of Oral Submucous Fibrosis: A Systematic Review And Meta-Analysis”. Journal of Oral Pathology and Medicine 48.2 (2019): 99-107. 
  17. Bagan José., et al. "Topical Therapies For Oral Lichen Planus Management And Their Efficacy: A Narrative Review”. Current Pharmaceutical Design 18.34 (2012): 5470-5480. 
Citation: José López-López and Albert Estrugo Devesa. “Oral Lichen Planus and Aloe Vera”. EC Dental Science 19.2 (2020): 01-06.

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