Review Article
Volume 18 Issue 12 - 2019
Early Childhood Carious: A Literature Review
Basim Abdullah Al Musa1*, Danya Mansoor Al Hamad2, Noura Saleh Bin Saeed3, Bashayer Mohammed Alhazmi4, Rand Bin Salloum5, Khadija Sameer Alabdrabalridha6, Fawaz Saleh Alolaywi7, Amal Masud Alaabs8, Khaled Saad Alkhaldi9, Mohammed Osama Bader6 and Abbas Hassan Al Alshaikh10
1Department of Pediatric Dentistry, Dammam Medical Complex, Dammam, Saudi Arabia
2College of Dentistry, Medical university of Lodz, Lodz, Poland
3College of Dentistry, Alfarabi Colleges, Jeddah, Saudi Arabia
4College of Dentistry, Jazan University, Jazan, Saudi Arabia
5College of Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia
6Department of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
7Primary Health Care, Ministry of Health, Qassim, Saudi Arabia
8College of Dentistry, Imam Abdurahman bin Faisal University, Dammam, Saudi Arabia
9Hazm Sahik Primary Healthcare Center, Ministry of Health, Safwa, Saudi Arabia
10Department of Dentistry, Rafha Specialist Dental Center, Rafha, Saudi Arabia
*Corresponding Author: Basim Abdullah Al Musa, Department of Pediatric Dentistry, Dammam Medical Complex Dammam, Saudi Arabia.
Received: October 21, 2019; Published: November 06, 2019


Early Childhood Caries (ECC) is defined as having one or more decayed teeth, missed teeth (due to caries), or filled tooth surfaces; involving any primary tooth in children aged 71 months or younger. It represents a rising global health problem, with a high prevalence that may reach up to 94% in some communities. We have performed an extensive literature search of the Medline, Cochrane, and EMBASE databases to identify any papers relevant to ECC. ECC found to be multifactorial in nature, resulting from an interaction between micro-organisms, dietary, and socio-economic factors. Its progression may lead to pain and reduced ability to eat, with subsequent effect on child growth and development. The focus on the prevention and management of ECC should be modifying these factors along with proper health education of both the parents and the child.

Keywords: American Academy of Pediatric Dentistry (AAPD); Early Childhood Caries (ECC)


    1. American Academy of Pediatric Dentistry. "Policy on Early Childhood Caries (Ecc): Classifications, Consequences, and Preventive Strategies”. Pediatric Dentistry 38.6 (2016): 52-54. 
    2. Chen Kitty J., et al. "Prevalence of Early Childhood Caries among 5-Year-Old Children: A Systematic Review”. Journal of Investigative and Clinical Dentistry 10.1 (2019): e12376. 
    3. American Dental Association. "Statement on Early Childhood Caries”. 
    4. Bagramian RA., et al. "The Global Increase in Dental Caries. A Pending Public Health Crisis”. American Journal of Dentistry 22.1 (2009): 3-8. 
    5. Gupta P., et al. "Role of Sugar and Sugar Substitutes in Dental Caries: A Review”. ISRN Dentistry (2013): 519421. 
    6. Alazmah A. "Early Childhood Caries: A Review”. Journal of Contemporary Dental Practice 18.8 (2017): 732-737. 
    7. Kawashita Yumiko., et al. "Early Childhood Caries”. International Journal of Dentistry (2011): 725320. 
    8. Mantonanaki M., et al. "Prevalence of Dental Caries in 5-Year-Old Greek Children and the Use of Dental Services: Evaluation of Socioeconomic, Behavioural Factors and Living Conditions”. International Dental Journal 63.2 (2013): 72-79. 
    9. Ferraz NK., et al. "Clinical Consequences of Untreated Dental Caries and Toothache in Preschool Children”. Pediatric Dentistry 36.5 (2014): 389-392. 
    10. Ortiz FR., et al. "Toothache, Associated Factors, and Its Impact on Oral Health-Related Quality of Life (Ohrqol) in Preschool Children”. Brazilian Dental Journal 25.6 (2014): 546-553. 
    11. Li LW., et al. "Anthropometric Measurements and Dental Caries in Children: A Systematic Review of Longitudinal Studies”. Advances in Nutrition 6.1 (2015): 52-63. 
    12. Neves Érick Tássio Barbosa., et al. "Absenteeism among Preschool Children Due to Oral Problems”. Journal of Public Health 24.1 (2016): 65-72. 
    13. Allareddy V., et al. "Hospital-Based Emergency Department Visits with Dental Conditions among Children in the United States: Nationwide Epidemiological Data”. Pediatric Dentistry 36.5 (2014): 393-399. 
    14. Van Houte Johannes. "Role of Micro-Organisms in Caries Etiology”. Journal of Dental Research 73.3 (1994): 672-681. 
    15. Berkowitz Robert J. "Causes, Treatment and Prevention of Early Childhood Caries: A Microbiologic Perspective”. Journal-Canadian Dental Association 69.5 (2003): 304-307. 
    16. Caufield PW., et al. "Initial Acquisition of Mutans Streptococci by Infants: Evidence for a Discrete Window of Infectivity”. Journal of Dental Research 72.1 (1993): 37-45. 
    17. Berkowitz Robert J. "Mutans Streptococci: Acquisition and Transmission”. Pediatric Dentistry 28.2 (2006): 106-09. 
    18. Wan AKL., et al. "A Longitudinal Study of Streptococcus Mutans Colonization in Infants after Tooth Eruption”. Journal of Dental Research 82.7 (2003): 504-508. 
    19. Kozai Katsuyuki., et al. "Intrafamilial Distribution of Mutans Streptococci in Japanese Families and Possibility of Father‐to‐Child Transmission”. Microbiology and Immunology 43.2 (1999): 99-106. 
    20. Li Yihong., et al. "Mode of Delivery and Other Maternal Factors Influence the Acquisition of Streptococcus Mutans in Infants”. Journal of Dental Research 84.9 (2005): 806-811. 
    21. Milgrom P., et al. "Dental Caries and Its Relationship to Bacterial Infection, Hypoplasia, Diet, and Oral Hygiene in 6- to 36-Month-Old Children”. Community Dentistry and Oral Epidemiology 28.4 (2000): 295-306. 
    22. Marshall TA., et al. "Dental Caries and Beverage Consumption in Young Children”. Pediatrics 112.3 (2003): e184-e191. 
    23. Bowen WH and RA Lawrence. "Comparison of the Cariogenicity of Cola, Honey, Cow Milk, Human Milk, and Sucrose”. Pediatrics 116.4 (2005): 921-926. 
    24. Kawashita Y., et al. "Pediatrician-Recommended Use of Sports Drinks and Dental Caries in 3-Year-Old Children”. Community Dental Health Journal 28.1 (2011): 29-33. 
    25. Kashket S and DP DePaola. "Cheese Consumption and the Development and Progression of Dental Caries”. Nutrition Reviews 60.4 (2002): 97-103. 
    26. Bowen WH and SK Pearson. "Effect of Milk on Cariogenesis”. Caries Research 27.6 (1993): 461-466. 
    27. Bowen WH., et al. "Influence of Milk, Lactose-Reduced Milk, and Lactose on Caries in Desalivated Rats”. Caries Research 25.4 (1991): 283-286. 
    28. Fejerskov O and E Kidd. “Dental Caries: The Disease and Its Clinical Management”. Wiley (2009). 
    29. Valaitis R., et al. "A Systematic Review of the Relationship between Breastfeeding and Early Childhood Caries”. Canadian Journal of Public Health 91.6 (2000): 411-417. 
    30. Iida H., et al. "Association between Infant Breastfeeding and Early Childhood Caries in the United States”. Pediatrics 120.4 (2007): e944-e952. 
    31. Harris R., et al. "Risk Factors for Dental Caries in Young Children: A Systematic Review of the Literature”. Community Dental Health 21.1 (2004): 71-85. 
    32. Aida J., et al. "An Ecological Study on the Association of Public Dental Health Activities and Sociodemographic Characteristics with Caries Prevalence in Japanese 3-Year-Old Children”. Caries Research 40.6 (2006): 466-472. 
    33. Ramos-Gomez FJ., et al. "Bacterial, Behavioral and Environmental Factors Associated with Early Childhood Caries”. Journal of Clinical Pediatric Dentistry 26.2 (2002): 165-173. 
    34. Marthaler TM. "Changes in Dental Caries 1953-2003”. Caries Research 38.3 (2004): 173-181. 
    35. Curzon ME and AJ Preston. "Risk Groups: Nursing Bottle Caries/Caries in the Elderly”. Caries Research 38.1 (2004): 24-33. 
    36. Krol David M. "Dental Caries, Oral Health, and Pediatricians”. Current Problems in Pediatric and Adolescent Health Care 33.8 (2003): 253-270. 
    37. Bedos C., et al. "Dental Caries Experience: A Two-Generation Study”. Journal of Dental Research 84.10 (2005): 931-936. 
    38. Poulton Richie., et al. "Association between Children's Experience of Socioeconomic Disadvantage and Adult Health: A Life-Course Study”. Lancet (London, England) 360.9346 (2002): 1640-1645. 
    39. Kawashita Y., et al. "Dental Caries in 3-Year-Old Children Is Associated More with Child-Rearing Behaviors Than Mother-Related Health Behaviors”. Journal of Public Health Dentistry 69.2 (2009): 104-110. 
    40. Dye BA., et al. "Trends in Oral Health Status: United States, 1988-1994 and 1999-2004”. Vital and Health Statistics Series 11 248 (2007): 1-92. 
    41. Beltran-Aguilar ED., et al. "Surveillance for Dental Caries, Dental Sealants, Tooth Retention, Edentulism, and Enamel Fluorosis--United States, 1988-1994 and 1999-2002”. MMWR Surveillance Summaries 54.3 (2005): 1-43. 
    42. Carino KM., et al. "Early Childhood Caries in Northern Philippines”. Community Dentistry and Oral Epidemiology 31.2 (2003): 81-89. 
    43. Thitasomakul S., et al. "A Longitudinal Study of Early Childhood Caries in 9- to 18-Month-Old Thai Infants”. Community Dentistry and Oral Epidemiology 34.6 (2006): 429-436. 
    44. Skeie MS., et al. "Caries Patterns in an Urban Preschool Population in Norway”. European Journal of Paediatric Dentistry 6.1 (2005): 16-22. 
    45. Marcus Ht Fung., et al. "Early Childhood Caries: A Literature Review”. Journal of Oral Hygiene and Health 1.1 (2013): 1-7. 
    46. Yiu CK and SH Wei. "Management of Rampant Caries in Children”. Quintessence International 23.3 (1992): 159-168. 
    47. Johnston T and LB Messer. "Nursing Caries: Literature Review and Report of a Case Managed under Local Anaesthesia”. Australian Dental Journal 39.6 (1994): 373-381. 
    48. Eidelman E., et al. "Histopathology of the Pulp in Primary Incisors with Deep Dentinal Caries”. Pediatric Dentistry 14.6 (1992): 372-375. 
    49. Ismail AI. "Determinants of Health in Children and the Problem of Early Childhood Caries”. Pediatric Dentistry 25.4 (2003): 328-333. 
    50. Chu CH. "Treatment of Early Childhood Caries: A Review and Case Report”. General Dentistry 48.2 (2000): 142-148. 
    51. American Academy of Pediatric Dentistry. "Perinatal and Infant Oral Health Care”. 
    52. Lo EC., et al. "Arresting Dentine Caries in Chinese Preschool Children”. International Journal of Paediatric Dentistry 8.4 (1998): 253-260. 
    53. Autio-Gold JT and F Courts. "Assessing the Effect of Fluoride Varnish on Early Enamel Carious Lesions in the Primary Dentition”. Journal of the American Dental Association 132.9 (2001): 1247-1318. 
    54. Nyvad B and O Fejerskov. "Assessing the Stage of Caries Lesion Activity on the Basis of Clinical and Microbiological Examination”. Community Dentistry and Oral Epidemiology 25.1 (1997): 69-75.
    55. Bader JD., et al. "A Systematic Review of Selected Caries Prevention and Management Methods”. Community Dentistry and Oral Epidemiology 29.6 (2001): 399-411. 
    56. Lopez L., et al. "Topical Antimicrobial Therapy in the Prevention of Early Childhood Caries: A Follow-up Report”. Pediatric Dentistry 24.3 (2002): 204-206. 
    57. Redig DF. "A Comparison and Evaluation of Two Formocresol Pulpotomy Technics Utilizing "Buckley's" Formocresol”. Journal of Dentistry for Children 35.1 (1968): 22-30.
Citation: Basim Abdullah Al Musa., et al. “Early Childhood Carious: A Literature Review”. EC Dental Science 18.12 (2019): 01-07.

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