Research Article
Volume 17 Issue 5 - 2018
Comparison of Steroids and Calcineurin Inhibitors in the Management of Oral Lichen Planus– A Meta-Analysis
Ch Sai Kiran1*, P Ramaswamy2 and Santosh N3
1Reader, Department of Oral Medicine and Radiology, St. Joseph Dental College, Eluru, Andhra Pradesh, India
2Professor and Head of the department, Department of Oral Medicine and Radiology, St. Joseph Dental College, Eluru, Andhra Pradesh, India
3Postgraduate, Department of Oral Medicine and Radiology, St. Joseph Dental College, Eluru, Andhra Pradesh, India
*Corresponding Author: Ch Sai Kiran, Reader, Department of Oral Medicine and Radiology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.
Received: February 27, 2018; Published: April 28, 2018
Citation: Ch Sai Kiran., et al. “Comparison of Steroids and Calcineurin Inhibitors in the Management of Oral Lichen Planus- A Meta-Analysis”. EC Dental Science 17.5 (2018): 606-612.
Abstract
Context: Lichen planus is the one of the most common muco-cutaneous disorder in India with a wide variety of therapeutic modalities such as Steroids and immuno-modulators.
Aim and Objective: The present study was done to compare the efficacy of corticosteroids with immune-suppressants like Calcineurin inhibitors in treating Oral lichen planus (OLP).
Material and Methods: PubMed, Scopus and Google scholar database were searched using keywords Oral lichen planus, Corticosteroids, Triamcinolone, Clobetasol, Immuno-modulators, Tacrolimus, Pimecrolimus, local application. From each article, information regarding the type of drug used, duration, response to the drug, side effects and recurrences were recorded. The data was entered in a spreadsheet and subjected meta-analysis of relative risk and mean difference.
Results: A total of 56 studies were obtained through the search. Out of them 40 articles were excluded as they contained only one drug in the treatment of OLP (either corticosteroid or Calcineurin inhibitor). Out of 16 articles, 3 articles have study methodologies below standard, and the statistical data was not complete or clear. Hence a total of 13 articles were included in the study, which were subjected to meta-analysis. Calcineurin inhibitors are 1.31 times more potent than corticosteroids in curing OLP. Steroid cases have 1.69 times more recurrences when compared to Calcineurin inhibitors. Calcineurin inhibitors produced higher side effects when compared with Steroids. Steroids showed significant reduction in Visual analog scale (VAS) score when compared to Calcineurin inhibitors.
Conclusion: Our study proved that Steroids are best in giving symptomatic relief (such as reducing burning sensation) to the patient with minimal side effects. On the other hand, Calcineurin inhibitors are profound in suppressing the disease with minimal recurrence rate.
Keywords: Oral Lichen Planus; Corticosteroids; Triamcinolone; Clobetasol; Immuno-Modulators; Tacrolimus; Pimecrolimus
Copyright: © 2018 Ch Sai Kiran., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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