Research Article
Volume 17 Issue 5 - 2018
Efficacy of Lycopene on Burning Sensation and Mouth Opening in Oral Submucous Fibrosis
Ahsan Ullah*, Namal Pervez, Muhammad Ishfaq and Shaheen Anjum
Nishtar Medical College, Multan, Pakistan
*Corresponding Author: Ahsan Ullah, Nishtar Medical College, Multan, Pakistan.
Received: February 14, 2018; Published: April 21, 2018
Citation: Ahsan Ullah., et al. “Efficacy of Lycopene on Burning Sensation and Mouth Opening in Oral Submucous Fibrosis”. EC Dental Science 17.5 (2018): 537-543.
Abstract
Introduction: Oral submucous fibrosis is a chronic premalignant condition of oral cavity, pharynx and upper digestive tract [1]. Primary etiology is areca nut, chewing. Nutritional deficiencies increases the risk of severity [3]. Areca nut disrupting the homeostatic balance between synthesis, and degradation of extra cellular matrix [4]. Lycopene is newer Antioxidants restrict the free radical injury to cells and cellular components [5]. Lycopene gives curative effect by inhibition of abnormal fibroblast, up regulation of lymphocytes resistance to stress.
Objective: Determine the efficacy of Lycopene on burning sensations, and mouth opening, in Oral submucous fibrosis.
Duration of Study: 6 months after approval of synopsis (18 August 2015 to 18 February 2016).
Study Type: Descriptive, case series.
Sitting:Out patients department, Oral and Maxillofacial Surgery Nishtar Institute of Dentistry Multan.
Materials and Methods: After approval of ethical committee and taking written consent patient were included in the study. Data was collected using structured questionnaire. Pretreatment mouth opening using divider and burning sensation on VAS recorded and compared to post treatment.
Results: The present study comprised of 101 patients of oral submucous fibrosis (OSMF). OSMF patients included 53 (52.4%) male and 48 (47.05%) female patients. Majority 70 (69.3%) have habit of pan chewing. Efficacy of lycopene for burning sensations pretreatment and post treatment were analysed. P value 0.00001(statistically significant). Similarly for mouth opening compared. P value 0.002 (statistically significant).
Conclusion: Lycopene is effective in the management of oral submucous fibrosis.
Keywords: Colorectal Cancer; Review; Screening; Treatment
Copyright: © 2018 Ahsan Ullah., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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