Research Article
Volume 17 Issue 4 - 2018
Protective Effect of Low Concentrated Boric Acid in Oral Candidiasis: An In Vitro Study
Shikha Tarang1, Tyler Ushio1, Michael Harrison1, Manisha Virdi1, Joseph Franco2, Laura Harris-Vieyra3, Sonia Maria Rocha-Sanchez1*
1Department of Oral Biology, Creighton University School of Dentistry, Omaha, NE, USA
2Department of Oral Diagnosis, Creighton University School of Dentistry, Omaha, NE, USA
3Department of Periodontics, Creighton University School of Dentistry, Omaha, NE, USA
*Corresponding Author: Sonia Maria Rocha-Sanchez, Department of Oral Biology, Creighton University School of Dentistry, Omaha, NE, USA.
Received: January 29, 2018; Published: March 05, 2018
Citation: Sonia Maria Rocha-Sanchez., et al. “Protective Effect of Low Concentrated Boric Acid in Oral Candidiasis: An In Vitro Study”. EC Dental Science 17.4 (2018): 302-308.
Abstract
Candida albicans (C. albicans) is the most common human commensal fungi found adhered to the mucosal membranes of the oral cavity. Under certain conditions, previously asymptomatic colonization can become virulent, resulting in oral candidiasis (OC). Acrylic denture bases are porous and can potentially harbor infection in the denture, the denture cup and the soft tissues of the mouth, promoting C. albicans overgrowth. Patients with OC who wear removable dentures are not only susceptible to Candida infection, but also to reinfection. The present study aimed to test the efficiency of using low concentrations of boric acid (BA) solution for the topical treatment of OC, and to prevent reinfection. Overall, our findings support the potential use of low concentrated BA solutions for the topical treatment of OC, disinfection of dentures, and prevention of reinfection.
Keywords: Boric Acid; Candida albicans; Oral Candidiasis; Oral Fibroblasts; Denture-Resin Acrylic Material
Copyright: © 2018 Sonia Maria Rocha-Sanchez., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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