Research Article
Volume 17 Issue 2 - 2018
Bone Turnover Changes During Human Orthodontic Tooth Movement - An assessment of Phosphatases Activity in Gingival Crevicular Fluid
Arif Yezdani1*, Nilendu Sekhar Dhar2, R Venu Murali3, WS Manjula4, Kesavaram Padmavathy5 and Krishna Prasanth6
1Professor and Director, Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
2Post Graduate Student, Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
3Former Professor and HOD, Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
4Professor and Director of Post Graduate Studies, Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
5Associate Professor, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
6Assistant Professor, Department of Epidemiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India
*Corresponding Author: Arif Yezdani, Professor and Director, Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Narayanapuram, Pallikaranai, Chennai, India.
Received: December 09, 2017; Published: January 22, 2018
Citation: Arif Yezdani., et al. “Bone Turnover Changes During Human Orthodontic Tooth Movement - An assessment of Phosphatases Activity in Gingival Crevicular Fluid”. EC Dental Science 17.2 (2018): 51-62.
Abstract
Objective: The purpose of this longitudinal study was to ascertain whether acid and alkaline phosphatase activities in gingival crevicular fluid were indicative of bone turnover changes that occurred during one orthodontic cycle of canine retraction in human subjects.
Material and Methods: Seven patients (two males and five females); mean age of 23 years were selected and strapped up with pre-adjusted edgewise appliance (MBT 0.022 x 0.028-inch slot). Leveling and aligning was completed prior to distalization of the maxillary canines. The right side maxillary canine was the distalized canine (DC) and hence the experimental tooth whereas the contralateral canine (CC) was the control tooth. From the mesial and distal tooth sites of DC and CC the gingival crevicular fluid (GCF) was collected immediately before canine retraction, an hour after and subsequently weekly for a period of 4 weeks and assayed for phosphatase activities. The results were expressed as total acid and alkaline phosphatases (ACP and ALP) activities determined spectrophotometrically at 300C at 405 nm.
Results: Increased ACP activity was observed in the distal site of distalized canine with a significant peak on the 21st day whereas increased ALP activity was observed in the mesial site of distalized canine with significant peaks on the 14th and 28th day.
Conclusion: The alternating peaks of acid and alkaline phosphatase activity in GCF was indicative of alveolar bone turnover changes that occurred during canine retraction indicating that orthodontic tooth movement could be biologically monitored to facilitate patient compliance and optimal force delivery.
Keywords: Acid Phosphatase; Alkaline Phosphatase; Gingival Crevicular Fluid; Orthodontic Tooth Movement
Copyright: © 2018 Arif Yezdani., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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