Review Article
Volume 7 Issue 2 - 2020
Hyponatremia: An Uncommon Trigger for Takotsubo Cardiomyopathy
Fulvio Cacciapuoti1*, Pio Caso1 and Federico Cacciapuoti2
1Cardiology Department, “V. Monaldi” Hospital Naples, Italy
2Department of Internal Medicine, “L. Vanvitelli” University Naples, Italy
*Corresponding Author: Fulvio Cacciapuoti, Cardiology Department, “V. Monaldi” Hospital Naples, Italy.
Received: December 16, 2019; Published: January 18, 2020


Background: Takotsubo or stress cardiomyopathy is a cause of reversible left ventricular systolic dysfunction in the absence of coronary artery disease. 

Methods: Cardiomyopathy is rather frequent in post-menopausal, older women. In these, the pathogenesis is induced by physical or emotional stressors in the absence of protective effect of estrogen on cardiovascular system. But, some endocrine stimuli (thyroid dysfunction surrenal insufficiency, diabetes mellitus, hypoglycemia pheochromocytoma) act as less frequent triggers of Takotsubo cardiomyopathy (TC).

Results: Hyponatremia, as expression of some pathologies ranging from nephrotic syndrome, cardiac failure and polydipsia, or as manifestation of syndrome of inappropriate secretion of antidiuretic hormone (SIADH), can also act as trigger of  TC. 

Conclusions: Hyposodiemia also acts by catecholamine excess  deriving from the central nervous system and reduced serum levels of Na+, that impairs the Na+/Ca++ myocardial membrane pump.

Keywords: Takotsubo Cardiomyopathy; Endocrine and dys-Autonomic Triggers; Hyponatremia; SIADH


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Citation: Fulvio Cacciapuoti., et al. “Hyponatremia: An Uncommon Trigger for Takotsubo Cardiomyopathy”. EC Cardiology 7.2 (2020): 01-07.

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