Research Article
Volume 7 Issue 1 - 2020
How to Regulate for Human Physiological Functions by Fermented Material
Yuma Katoh1, Isao Horiuchi1, Hisako Izumi2 and Nobuo Yamaguchi2,3*
1Department of Respiratory Medicine, Tohkai Central Hospital, Gifu, Japan
2Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan
3Department of Fundamental Research for CAM, Kanazawa Medical University, Ishikawa, Japan
*Corresponding Author: Nobuo Yamaguchi, Department of Fundamental Research for CAM, Kanazawa Medical University, Ishikawa, Japan.
Received: November 29, 2019; Published: December 12, 2019


Background: There are many fermented foods either botanical or vertebrate source everywhere in the world. We have been investigated the mechanism of action by these products why these are good for many physiological functions. However, the focus of the products seem to attract as nutritional point of view such as taste and flavor, but few was for biomedical point of view. 

Introduction: Fermentation process are close to digestive process by enzymes in digestive tract. However, we have found that there are difference between stating molecular weight for select to their destiny, digestion by the cleavage enzyme or pass through intestinal tube without attack by the digestive enzyme. The latter one is the fate of fermented material but full molecular original/natural food is not.

Material and Method: A malted rice were prepared by the microorganisms from plum flower (Enterococcus faecalis, MPF). This products were exhibited by safe in animal safety test. The trial was made to investigate the relation between the molecular styles and complement activation.

Results: Our results in animal model showed that MPF was the safe for the animal safety test. Four weeks after the administration, granulocyte and lymphocyte ratio was regulated as modulate and neutral. 


  1. A multi-molecular saccharide are attacked by digestive enzyme in digestive tract. 
  2. However, middle molecular saccharide, such as oligo-saccharide made by fermentation escape from digestive enzyme, when that introduced in digestive tract. 
  3. The molecular size less than oligo-saccharide could pass through intestinal barrier to the lymph.
  4. A multi-chained saccharide can activate alternative complement pass way.
  5. The activated complement fragments can augment many physiological function including craniological system.
  6. The activated fragment of alternative pathway Bf was proved by the immuno-precipitin method after electrophoresis of human serum. 

Keywords: Complement; Alternative Pathway; Multi-Molecular Sugar Chain; Fermentation; Digestive Tract; Malted Rice; Mono-Saccharide; Disaccharide; Oligo-Saccharide; Poly-Saccharide


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Citation: Nobuo Yamaguchi., et al. “How to Regulate for Human Physiological Functions by Fermented Material”. EC Cardiology 7.1 (2020): 01-11.

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