Research Article
Volume 7 Issue 2 - 2020
Congenital Heart Diseases in Saudi Arabia: Epidemiologic Overview during the Period of 1988 - 2008
Abdullah Alabdullagader1*, Amin Alagib2 and Ahmed Ibrahim3
1Senior Consultant Paediatric Cardiologist, Electro physiologist, Prince Sultan Cardiac Centre-Alhassa, Saudi Arabia
2Paediatric Consultant, Assistant Professor, University of Medical Sciences and Technology, Sudan
3Consultant of Epidemiology, Prince Sultan Cardiac Centre- Alhassa, Saudi Arabia
*Corresponding Author: Abdullah Alabdullagader, Senior Consultant Paediatric Cardiologist, Electro physiologist, Prince Sultan Cardiac Centre-Alhassa, Saudi Arabia.
Received: December 31, 2019; Published: January 11, 2020


Background: Congenital heart disease is the most common congenital disorder in newborns. The prevalence of congenital heart disease is unclear, with underestimates of patients who actually have the diseases. In this study, we present an overview of the frequency, prevalence, geographical distribution, extra cardiac disorders and some factors associated with congenital heart diseases in children in Saudi Arabia.

Aim: To describe frequency, distribution and prevalence of congenital heart diseases and associated extra cardiac diseases in children during the period of 1988 - 2008 in Saudi Arabia.

Methods: Descriptive retrospective study of congenital heart diseases for databases collected from all paediatric and maternal hospitals in Saudi Arabia. A total number of 4465 patients were reported from all regions in Saudi Arabia. All patients with congenital heart defects had their diagnoses confirmed by paediatric cardiologist with use of at least echocardiography.

The frequency and prevalence of the anomalies were classified according to ICD-10 classification of congenital heart diseases. Types of congenital heart diseases were compared between geographical areas.

Findings: A total number of 4465 patients were diagnosed with congenital heart diseases, with prevalence of 2.01 per 1000 in children age 0- 4 years of age. The majority of them of them 3436 (77%) were reported from central region. The stratification of the diseases was as fellow: 1078 (24.1%) VSD, 786 (17.6%) PS, 493 (11%) ASD, 473 (10.6%) PDA, 229 (5.1%).

TOF and 202 (4.5%) HLHS. There was an overall statistically significant difference in reported CHD diseases (51% vs. 49%; 0.05) for male to female respectively. Several extra cardiac anomalies were observed associated with CHD, the most frequent were, chromosomal anomaly which was mainly Down syndrome 32.3%, genito-urinary abnormality 14%, Hematological disorders 9.4%, metabolic and endocrine disorders 9.2% and central nervous system defect 8.5%. Ventricular septal defect was the most frequent cyanotic anomaly, and tetralogy of Fallot was the most frequent cyanotic anomaly.

Conclusion: Children with congenital heart defects were mainly reported from central region, ventricular septal defect was the most frequent heart defect, Down syndrome predominant extra cardiac disease.

Keywords: Congenital Heart Disease; Epidemiology; Extra-Cardiac Anomalies


  1. Mitchell SC., et al. “Congenital heart disease in 56,109 births. Incidence and natural history”. Circulation 43 (1971): 323-332.
  2. Hoffman JIE and Christianson R. “Congenital heart disease in a cohort of 19.502 births with long-term follow-up”. American Journal of Cardiology 42 (1978): 641-647.
  3. Samánek M., et al. “Distribution of age at death in children with congenital heart disease who died before the age of 15”. British Heart Journal 59 (1988): 581-585.
  4. Hoffman JIE and Kaplan S. “The incidence of congenital heart disease”. Journal of the American College of Cardiology 39 (2002): 1890-1900.
  5. Wren C. “The epidemiology of cardiovascular malformations”. In: Moller JH, Hoffman JIE, Benson DW, van Hare GF, Wren C, editors. Pediatric Cardiovascular Medicine. Oxford, England: Wiley-Blackwell (2012): 268-275.
  6. Julien IE Hoffman. “The global burden of congenital heart disease”. Cardiovascular Journal of Africa 24.4 (2013): 141-145. 
  8. W Greer AL., et al. “Geographical distribution of congenital heart defects in Saudi Arabia”. Annals of Saudi Medicine 25.1 (2005): 63- 69.
  9. Amirah M., et al. “The epidemiology of congenital heart diseases in Saudi Arabia: A systematic review”. Journal of Public Health and Epidemiology 7 (2015): 232-240.
  10. Hoffman JIE., et al. “Prevalence of congenital heart disease”. American Heart Journal 147.3 (2004): 425-439.
  11. Wu MH., et al. “Prevalence of congenital heart disease at live birth in Taiwan”. The Journal of Pediatrics 156.5 (2010): 782-785.
  12. JM Mulder. “Epidemiology of adult congenital heart disease: demographic variations worldwide”. Netherlands Heart Journal 20.12 (2012): 505-508.
  13. Yanji Qu., et al. “Incidence of Congenital Heart Disease: The 9-Year Experience of the Guangdong Registry of Congenital Heart Disease, China”. PLoS One 11.7 (2016): e0159257. 
  14. Fen Liu., et al. “Prevalence of Congenital Heart Disease in Xinjiang Multi-Ethnic Region of China”. PLoS One. 2015 10.8 (2015): e0133961. 
  15. Miyague., et al. “Congenital heart defects in children and adolescents”. Arquivos Brasileiros de Cardiologia 80 (2003): 274-278.
  16. Alabdulgader AA. “Congenital heart disease in 740 subjects: Epidemiological aspects”. Annals of Tropical Paediatrics 21.2 (2001): 111 -118.
  17. Abbag FI., et al. “Congenital heart diseases and other major anomalies in patients with Down syndrome”. Saudi Medical Journal 27.2 (2006): 219-222.
  18. Al-Jarallah AS., et al. “Down's syndrome and the pattern of congenital heart disease in a community with high parental consanguinity”. Medical Science Monitor 15.8 (2009): 409-412.
  19. Al-Mesned A., et al. “Incidence of severe congenital heart disease at the province of Al-Qassim, Saudi Arabia”. Congenital Heart Disease 7.3 (2012): 277-282.
  20. Almawazini AM and Al-Ghamdi AS. “Congenital heart disease in south-west Saudi Arabia”. Saudi Medical Journal 32.2 (2011): 195-196.
  21. Alnajjar AA., et al. “Pediatric heart diseases in Madina, Saudi Arabia. Current status and future expectations”. Saudi Medical Journal 30.9 (2009): 1186-1191.
  22. Alqurashi M., et al. “Symptomatic congenital heart disease in the Saudi Children and Adolescents”. Annals of Saudi Medicine 27.6 (2007): 442-444.
  23. Baht BA., et al. “Pattern of congenital heart disease among children in Madina Munawara”. Journal of the Saudi Heart Association 9 (1997): 16-19.
  24. Jaiyesimi F., et al. “Pattern of congenital heart disease in King Fahd Specialist Hospital, Buraidah”. Annals of Saudi Medicine 13.3 (1993): 407-411.
  25. “Congenital Heart Disease in Down Syndrome”. Pediatrics in Review 28 (2007): e19-e12.
  26. Kenna AP., et al. “Congenital heart disease in Liverpool: 1960-1969”. Quarterly Journal of Medicine 44.173 (1975): 17-44.
  27. Zabala LM and Guzzetta NA. “Cyanotic congenital heart disease (CCHD): focus onhypoxemia, secondary erythrocytosis, and coagulation alterations”. Paediatric Anaesthesia 25.10 (2015): 981-989.
  28. Meissner T., et al. “Hyperinsulinism in syndromal disorders”. Acta Paediatrica 90.8 (2001): 856-859.
  29. de Los Reyes E and Roach ES. “Neurologic complications of congenital heart disease and its treatment”. Handbook of Clinical Neurology 119 (2014): 49-59.
  30. Chéhab G., et al. “Congenital heart disease associated with gastrointestinal malformations”. Lebanese Medical Journal 55.2 (2007): 70-74. 
  31. Duess JW and Puri P. “Syndromic Hirschsprung's disease and associated congenital heart disease: a systematic review”. Pediatric Surgery International 31.8 (2015): 781-785.
  32. Feldt RH., et al. “Growth of children with heart disease”. The American Journal of Diseases of Children 117 (1969): 573-579.
Citation: Abdullah Alabdullagader., et al. “Congenital Heart Diseases in Saudi Arabia: Epidemiologic Overview during the Period of 1988 - 2008”. EC Cardiology 7.2 (2020): 01-07.

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