Review Article
Volume 7 Issue 2 - 2020
A New Look at the Causes of Heart Failure at Old Age
Alexander V Panov*
Institute of Molecular Biology and Biophysics, Academy of Sciences of Russia, Novosibirsk, Russian Federation
*Corresponding Author: Alexander V Panov, Institute of Molecular Biology and Biophysics, Academy of Sciences of Russia, Novosibirsk, Russian Federation.
Received: December 23, 2019; Published: January 20, 2020


Most of the time, researchers in different fields of Science develop certain ideas or conceptions For some time these conceptions exist separately, but from time to time something happens, and these separate ideas, like small parts of a complex puzzle, begin to fell into much larger Scientific picture. In this brief review we make an attempt to bind together recently published new data regarding age-associated mutations of mtDNA, roles of mitochondrial phospholipids cardiolipin (CL) and phosphatidylethanolamine (PEA) in mitochondrial functions, oxidation of fatty acids in the heart’s energy metabolism and in oxidative stress, for better understanding of the mechanisms of aging and age-associated heart diseases. We came to conclusion that increased β-oxidation of fatty acids in people at the ages after 50 - 60 accelerates production of perhydroxyl radical, which activates in the heart the nonenzymatic autoxidation of CL and PEA and polyunsaturated fatty acids (PUFA). Autooxidation of PUFA produces a racemic mixture of hundreds of toxic molecules that gradually make mitochondria dysfunctional. Due to a large redundancy of mitochondrial enzymes these widely variable harms remain unnoticed for a long time. We conclude that not mutated mtDNA, but slowly accumulating dysfunctions cause wear and tear of the heart.

Keywords: mtDNA; Cardiolipin (CL); Phosphatidylethanolamine (PEA); Polyunsaturated Fatty Acids (PUFA)


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Citation: Alexander V Panov. “A New Look at the Causes of Heart Failure at Old Age”. EC Cardiology 7.2 (2020): 01-07.

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