Case Report
Volume 9 Issue 1 - 2022
Carcinoid Heart Disease: Case Report and Literature Review
Hanane Mechal*, Hajar Bendahou, Meryem Haboub, Abdenacer Drighil, Leila Azzouzi and Rachida Habbal
Cardiology Department, University Hospital Center of Casablanca, Morocco
*Corresponding Author: Hanane Mechal, Cardiology department, University hospital center of Casablanca, Morocco.
Received: January 09, 2022; Published: January 27, 2022


We describe the case of a 51-year-old male patient, diagnosed with a neuroendocrine tumor, with liver metastases and carcinoid syndrome since January 2020. The patient had been treated with Somatostatin analogs (Somatuline), with a moderate decrease of tumor size. In September 2021, he presented aggravating dyspnea and symptoms of right heart failure. Transthoracic echocardiography revealed a right sided valvar involvement with thickened and restrictive leaflets of both tricuspid and pulmonary valves responsible for severe tricuspid and pulmonary regurgitations, associated with enlargement of right chambers suggestive of carcinoid heart disease.

Keywords: Carcinoid Heart Disease; Carcinoid Syndrome; Pulmonary Valve Stenosis; Tricuspid Valve Insufficiency; Neuroendocrine Tumors


  1. Yuan S-M. “Valvular Disorders in Carcinoid Heart Disease”. Brazilian Journal of Cardiovascular Surgery5 (2016): 400-405.
  2. Fox DJ and Khattar RS. “Carcinoid heart disease: presentation, diagnosis, and management”. Heart10 (2004): 1224-1228.
  3. Basson MD., et al. “Biology and management of the midgut carcinoid”. The American Journal of Surgery2 (1993): 288-297.
  4. Bernheim AM., et al. “Carcinoid heart disease in patients without hepatic metastases”. The American Journal of Cardiology2 (2007): 292-294.
  5. Chaowalit N., et al. “Carcinoid heart disease associated with primary ovarian carcinoid tumor”. The American Journal of Cardiology10 (2004): 1314-1315.
  6. Strickman NE., et al. “Carcinoid heart disease: a clinical pathologic, and therapeutic update”. Current Problems in Cardiology11 (1982): 1-42.
  7. Schweizer W., et al. “Carcinoid Heart Disease with Left-Sided Lesions”. Circulation 29 (1964): 253-257.
  8. Connolly HM., et al. “Outcome of cardiac surgery for carcinoid heart disease”. Journal of the American College of Cardiology2 (1995): 410-416.
  9. Pellikka PA., et al. “Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients”. Circulation4 (1993): 1188-1196.
  10. Westberg G., et al. “Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome”. British Journal of Surgery6 (2001): 865-872.
  11. Bhattacharyya S., et al. “Carcinoid Heart Disease”. Circulation 24 (2007): 2860-2865.
  12. Mansencal N., et al. “Assessment of patent foramen ovale in carcinoid heart disease”. American Heart Journal5 (2006): 1129.e1-1129.e6.
  13. Connolly HM., et al. “Surgical Management of Left-Sided Carcinoid Heart Disease”. Circulation1 (2001): I-36.
  14. Pandya UH., et al. “Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients”. Journal of the American College of Cardiology7 (2002): 1328-1332.
  15. Lundin L., et al. “Transoesophageal echocardiography improves the diagnostic value of cardiac ultrasound in patients with carcinoid heart disease”. British Heart Journal3 (1990): 190-194.
  16. Kulke MH and Mayer RJ. “Carcinoid tumors”. The New England Journal of Medicine11 (1999): 858-868.
  17. Janmohamed S and Bloom SR. “Carcinoid tumours”. Postgraduate Medical Journal858 (1997): 207-214.
  18. Anderson AS., et al. “Cardiovascular complications of malignant carcinoid disease”. American Heart Journal4 (1997): 693-702.
  19. Nielsen MS and Manners JM. “Valve replacement in carcinoid syndrome. Anaesthetic management for tricuspid and pulmonary valve surgery”. Anaesthesia 5 (1979): 494-499.
  20. Warner RRP and Castillo JG. “Carcinoid Heart Disease: The Challenge of the Unknown Known”. Journal of the American College of Cardiology 20 (2015): 2197-2200.
  21. Zimmermann W-H., et al. “Cardiac Grafting of Engineered Heart Tissue in Syngenic Rats”. Circulation 12-1 (2002): I-151.
  22. Laule M., et al. “Staged Catheter-Based Valve Treatment of Severe Carcinoid Heart Disease”. Neuroendocrinology3-4 (2016): 259-262.
  23. Luis SA and Pellikka PA. “Carcinoid heart disease: Diagnosis and management”. Best Practice and Research: Clinical Endocrinology and Metabolism1 (2016): 149-158.
Citation: Hanane Mechal., et al. “Carcinoid Heart Disease: Case Report and Literature Review”. EC Cardiology 9.1 (2022): 12-19.

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