Review Article
Volume 8 Issue 11 - 2021
Mindfulness Miscellany: Therapeutic Indications and Contraindications of Various Meditation Techniques on Specific Human Biomarkers and Conditions, Including Potential Immunomodulation in COVID-19
Nicholas A Kerna1,2*, ND Victor Carsrud3, Joseph Anderson II4, John V Flores5,6, Sahalia Rashid7, Hilary M Holets5,6 and Sudeep Chawla7
1SMC-Medical Research, Thailand
2First InterHealth Group, Thailand
3Lakeline Wellness Center, USA
4International Institute of Original Medicine, USA
5Beverly Hills Wellness Surgical Institute, USA
6Orange Partners Surgicenter, USA
7Chawla Health & Research, USA
*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: September 29, 2021; Published: October 26, 2021




Abstract

Meditation has been practiced by specific individuals and groups since ancient times, providing not only spiritual insights but also health benefits. Much more recently, meditation has been investigated for such health-promoting effects and disorder prevention. Transcendental meditation (TM) is the most notable and practiced form of meditation, spanning continents, cultures, and religious affiliations. TM was introduced to the Western world by the revered Maharishi Mahesh Yogi in the mid-twentieth century. Over subsequent decades, the practice of TM has spread globally. Its popularity is based primarily on its ease of learning, being unaffiliated with any religion or philosophy, the relatively short time required each day for its effective practice (two times per day, twenty minutes per session), near-global access for the novice to learn the meditation technique, and the frequently occurring, immediate benefits noted by new practitioners and sustained personal and social benefits in established practitioners.

This review covers a miscellany of meditation topics, highlighting the researched effects of TM on reducing inflammation, in establishing and maintaining healthy blood pressure, its adjuvant application for cancer patients, its potential in COVID-19, in regulating plasma glucose levels and lipid profiles (particularly in the diabetic and overweight and obese populations), as an effective immunomodulator, in enhancing longevity, accelerating wound repair—as well as TM’s overall safety and relatively rare adverse events from practicing TM. TM is highlighted as it is the most widely researched meditation techniques globally.

Keywords: Anti-Inflammatory Blood Pressure; Cancer; COVID-19; Immunomodulation; Lipid Profile; Longevity; Plasma Glucose; Psychodermatology

References

  1. Arias AJ., et al. “Systematic review of the efficacy of meditation techniques as treatments for medical illness”. Journal of Alternative and Complementary Medicine8 (2006): 817-832. https://pubmed.ncbi.nlm.nih.gov/17034289/
  2. Fortney L and Taylor M. “Meditation in medical practice: a review of the evidence and practice”. Primary Care1 (2010): 81-90. https://pubmed.ncbi.nlm.nih.gov/20188999/
  3. Rakicevic M. “27 Meditation Statistics for Your Well-Being in (2021). https://disturbmenot.co/meditation-statistics/
  4. Meditation: In-Depth. https://www.nccih.nih.gov/health/meditation-in-depth
  5. Some other types of meditation. https://www.headspace.com/meditation/techniques
  6. Behavior: The TM craze: 40 minutes to bliss". Time. 1975-10-13.
  7. Needleman J. “Transcendental Meditation". The New Rel1st edition.)”. Garden City N.Y.: Doubleday (1970): 132-147.
  8. Mahesh Yogi M. “The Science of Being and Art of Living”. Meridian Publishing (1963).
  9. Roth R. Transcendental Meditation. New York: Primus (1994). http://lakshminarayanlenasia.com/articles/Transcendental-Meditation.pdf
  10. The story of transcendental meditation. https://www.inverse.com/article/16579-is-transcendental-meditation-the-best-meditation-om-maybe
  11. Morris B. “Maharishi's Vedic Science and Technology: The Only Means to Create World Peace”. Modern Science and Vedic Science Journal1-2 (1992): 200.
  12. Feloni R. “History of transcendental meditation” (2016). https://www.businessinsider.in/strategy/how-the-offshoot-of-an-ancient-hindu-practice-popularized-by-the-beatles-made-its-way-to-wall-street/articleshow/55446161.cms
  13. Wallace RK. “Physiological effects of Transcendental Meditation”. Science 167 (1970): 1751-1754. https://pubmed.ncbi.nlm.nih.gov/5416544/
  14. Unsolved: Transcendental Meditation technique. https://handwiki.org/wiki/Unsolved:Transcendental_Meditation_technique
  15. Goldstein CM., et al. “Current Perspectives on the Use of Meditation to Reduce Blood Pressure”. International Journal of Hypertension (2012): 578397. https://pubmed.ncbi.nlm.nih.gov/22518287/
  16. Cleveland Clinic. Meditation (2018). https://my.clevelandclinic.org/health/articles/17906-meditation
  17. Jang JH., et al. “Effects of Mind-Body Training on Cytokines and Their Interactions with Catecholamines”. Psychiatry Investigation4 (2017): 483-490. https://pubmed.ncbi.nlm.nih.gov/28845176/
  18. Jevning R., et al. “Behavioral alteration of plasma phenylalanine concentration”. Physiology and Behavior5 (1977): 611-614. https://pubmed.ncbi.nlm.nih.gov/343124/
  19. Rainforth MV., et al. “Stress reduction programs in patients with elevated blood pressure: a systematic review and meta-analysis”. Current Hypertension Reports 9 (2007): 520-528. https://pubmed.ncbi.nlm.nih.gov/18350109/
  20. Walton KG., et al. “Psychosocial stress and cardiovascular disease Part 2: effectiveness of the Transcendental Meditation program in treatment and prevention”. Journal of Behavioral Medicine 28 (2002): 106-123. https://pubmed.ncbi.nlm.nih.gov/16463759/
  21. Ooi SL., et al. “Transcendental meditation for lowering blood pressure: An overview of systematic reviews and meta-analyses”. Complementary Therapies in Medicine 34 (2017): 26-34. https://pubmed.ncbi.nlm.nih.gov/28917372/
  22. Schneider R., et al. “A randomized controlled trial of stress reduction for hypertension in older African Americans”. Hypertension (1995): 26820-26827. https://pubmed.ncbi.nlm.nih.gov/7591024/
  23. Alexander CN., et al. “A trial of stress reduction for hypertension in older African Americans, II: sex and risk factor subgroup analysis”. Hypertension (1996): 28228-28237. https://pubmed.ncbi.nlm.nih.gov/8707387/
  24. Barnes VA., et al. “Impact of Transcendental Meditation on cardiovascular function at rest and during acute stress in adolescents with high normal blood pressure”. Journal of Psychosomatic Research4 (2001): 597-605. https://pubmed.ncbi.nlm.nih.gov/11595248/
  25. Anderson JW., et al. “Blood pressure response to transcendental meditation: a meta-analysis”. American Journal of Hypertension3 (2008): 310-316. https://pubmed.ncbi.nlm.nih.gov/18311126/
  26. Brook RD., et al. “Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the american heart association”. Hypertension6 (2013): 1360-1383. https://pubmed.ncbi.nlm.nih.gov/23608661/
  27. Wenneberg SR., et al. “A controlled study of the effects of the Transcendental Meditation program on cardiovascular reactivity and ambulatory blood pressure”. International Journal of Neuroscience 89 (1997): 15-28. https://pubmed.ncbi.nlm.nih.gov/9134445/
  28. Canter PH and Ernst E. “Insufficient evidence to conclude whether or not Transcendental Meditation decreases blood pressure: results of a systematic review of randomized clinical trials”. Journal of Hypertension 22 (2004): 2049-2054. https://pubmed.ncbi.nlm.nih.gov/15480084/
  29. Hartley L., et al. “Transcendental meditation for the primary prevention of cardiovascular disease”. The Cochrane Database of Systematic Reviews 12 (2014): CD010359. https://pubmed.ncbi.nlm.nih.gov/25436436/
  30. Cancer Research UK (2019). https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/complementary-alternative-therapies/individual-therapies/meditation
  31. Nidich SI., et al. “A randomized controlled trial of the effects of transcendental meditation on quality of life in older breast cancer patients”. Integrative Cancer Therapies3 (2009): 228-234. https://pubmed.ncbi.nlm.nih.gov/19815592/
  32. Mahone MC., et al. “fMRI during Transcendental Meditation practice”. Brain and Cognition 123 (2018): 30-33. https://www.researchgate.net/publication/323533221_fMRI_during_Transcendental_Meditation_practice
  33. Infante JR., et al. “Levels of immune cells in transcendental meditation practitioners”. The International Journal of Yoga Therapy2 (2014): 147-151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097901/
  34. Orme-Johnson D. “Medical care utilization and the transcendental meditation program”. Psychosomatic Medicine5 (1987): 493-507. https://pubmed.ncbi.nlm.nih.gov/3313489/
  35. Bay R and Bay F. “Combined Therapy Using Acupressure Therapy, Hypnotherapy, and Transcendental Meditation versus Placebo in Type 2 Diabetes”. Journal of Acupuncture and Meridian Studies3 (2011): 183-186. https://pubmed.ncbi.nlm.nih.gov/21981869/
  36. Paul-Labrador M., et al. “Effects of a Randomized Controlled Trial of Transcendental Meditation on Components of the Metabolic Syndrome in Subjects With Coronary Heart Disease”. Archives of Internal Medicine11 (2006): 1218-1224. https://pubmed.ncbi.nlm.nih.gov/16772250/
  37. Mills PJ., et al. “Beta-adrenergic receptor sensitivity in subjects practicing transcendental meditation”. Journal of Psychosomatic Research1 (1990): 29-33. https://www.sciencedirect.com/science/article/abs/pii/002239999090005O
  38. Schneider RH., et al. “Long-term effects of stress reduction on mortality in persons > or = 55 years of age with systemic hypertension”. The American Journal of Cardiology9 (2005): 1060-1064. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482831/
  39. Alexander CN., et al. “Transcendental meditation, mindfulness, and longevity: an experimental study with the elderly”. Journal of Personality and Social Psychology6 (1989): 950-964. https://pubmed.ncbi.nlm.nih.gov/2693686/
  40. Cooper MJ and Aygen MM. “Transcendental Meditation in the management of hypercholesterolemia”. Journal of Human Stress4 (1979): 24-27. https://www.reliasmedia.com/articles/65796-transcendental-meditation-and-prevention-of-cardiovascular-disease
  41. Cooper MJ and Aygen MM. “Effect of Transcendental Meditation on serum cholesterol and blood pressure”. Harefuah The Israel Medical Association Journal1 (1978): 1-2. https://journals.sagepub.com/doi/abs/10.4278/0890-1171-10.3.208
  42. Shenoi SD and Prabhu SS. “Psychodermatology: An Indian perspective”. Clinics in Dermatology6 (2018): 737-742. https://www.cidjournal.com/article/S0738-081X(18)30184-6/fulltext
  43. Farias M., et al. “Adverse events in meditation practices and meditation-based therapies: a systematic review”. Acta Psychiatrica Scandinavica5 (2020): 374-393. https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13225
  44. Lindahl JR., et al. “The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists”. PLoS One 12 (2017): e0176239. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176239
  45. Van Dam NT., et al. “Reiterated concerns and further challenges for mindfulness and meditation research: a reply to Davidson and Dahl”. Perspectives on Psychological Science - SAGE Journals 13 (2018): 66-69. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817993/
  46. Persinger MA. “Transcendental Meditation (TM) and General Meditation are Associated with Enhanced Complex Partial Epileptic-Like Signs: Evidence for “Cognitive” Kindling?” Perceptual and Motor Skills1 (1993): 80-82. https://pubmed.ncbi.nlm.nih.gov/8451153/
  47. Otis L. “Adverse effects of transcendental meditation”. In: D Shapiro, R Walsh, editors. Meditation: classic and contemporary perspectives. New York, NY: Aldine (1984): 201-208.
  48. Vieten C., et al. “Future directions in meditation research: Recommendations for expanding the field of contemplative science”. PLoS One 13 (2018): e0205740. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205740
  49. Persinger MA. “Striking EEG profiles from single episodes of glossolalia and transcendental meditation”. Perceptual and Motor Skills 58 (1984): 127-133. https://pubmed.ncbi.nlm.nih.gov/6371700/
  50. Rodríguez FM. “Estudio sobre “Efectos Adversos” Relacionados con la Meditación Study about Meditation Related “Side Effects”. Journal of Transpersonal Research 7 (2015): 188-198. https://www.researchgate.net/publication/309159591_Estudio_sobre_Efectos_Adversos_Relacionados_con_la_Meditacion_Study_about_Meditation_Related_Side_Effects
Citation: Kerna NA, Carsrud NDV, Anderson II J, Flores JV, Rashid S, Holets HM, Chawla S. “Mindfulness Miscellany: Therapeutic Indications and Contraindications of Various Meditation Techniques on Specific Human Biomarkers and Conditions, Including Potential Immunomodulation in COVID-19”. EC Cardiology 8.11 (2021): 06-15.

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