Review Article
Volume 8 Issue 8 - 2021
Aging and Age-Induced Cardiovascular Disease: Molecular Mechanism and Biomarkers for its Early Prognosis
Hemshankar Laugi1* and Hom Nath Chalise2,3
1Bal Kalyan Vidya Mandir, Biratnagar, Nepal
2Faculty Member, Department of Public Health, Nobel College Affiliated to Pokhara University, Sinamangal, Kathmandu, Nepal
3Vice President, Population Association of Nepal, Kathmandu Nepal
*Corresponding Author: Hemshankar Laugi, Bal Kalyan Vidya Mandir, Biratnagar, Nepal.
Received: July 05, 2021; Published: July 31, 2021


The world is witnessing a rapid demographic shift towards an aging population. Biologically, aging is gradual decline in the ability of a cell to perform its own function followed by cellular senescence. Aging-induced diseases are the leading causes of deaths which have plagued humankind. The purpose of this article is to discuss how molecular mechanism using biomarkers may be useful for the controlling of Cardiovascular diseases (CVD).

With age, imbalance in energy demand and supply occurs. This decreases cellular ability to repair and replace damaged cells. Telomere shortening, increase in oxidative stress, klotho deficiency, and epigenetic factors trigger cellular senescence with age. These factors disturb the original state of the body and hence, body becomes susceptible to a number of human diseases including CVD, cancer, diabetes, and Alzheimer’s disease. A number of functional and structural changes occurring in the heart with age induce reduction in stress tolerance causing decreased cardiac function.

The use of accurate, reliable, cheaper, and sensitive biomarkers greatly helps in the early prognosis of CVD, which prevents further complications and reduces death rate due to CVD.

Keywords: Cellular Aging; Apoptosis; Cardiovascular Disease; CVD Biomarkers; Senescence


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Citation: Hemshankar Laugi and Hom Nath Chalise. “Aging and Age-Induced Cardiovascular Disease: Molecular Mechanism and Biomarkers for its Early Prognosis”. EC Cardiology 8.8 (2021): 38-48.

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