Mini Review
Volume 8 Issue 7 - 2021
Subcellular Transplantation for Cardiac Ischaemia - The Exciting Future Unfolds
Pradeep Kumar Radhakrishnan1*, Sujatha Mohanty2, Gayathri Ananyajyothi Ambat1, Prashanthi Cherukuri1, Vasundara Gardas1, Nihas Nazer3, Arun Vijaya Kumar3, Murugan Sushamma3, Nazer Y A3 and Venugopal P2
1Gitam University, India
2AIIMS, India
3Travancore Heart Institute, India
4University of Chicago, USA
*Corresponding Author: Pradeep Kumar Radhakrishnan, MCh CTVS AIIMS, Postdoctoral Fellow CTVS, Postdoctoral Fellow ECMO, FIACS, FACC, Global MBA Lond, CPDH IISc, Professor, Chief Division of Cardiothoracic and Vascular Surgery, GIMSR Gitam University, India.
Received: April 05, 2021; Published: June 25, 2021




Abstract

Mitochondria known as power house of the cell are intimately linked to cellular origin and existence, enabling the conversion of oxygen to energy. Ischaemia ranks as a forerunner in mitochondrial damage leading to cell death. Replacing mitochondria in ischaemia situations like stroke or myocardial infarction opens up multitude of possibilities in treatment domain. To mitigate cellular dysfunction, mitochondrial transplantation is now an acceptable form of treatment of ischaemia reperfusion injury [1]. Real world applications in pediatric ischaemia reperfusion has been showed by the Boston Group [2]. Usefulness of this mode of treatment now extends to graft function improvement in transplantation scenarios too. From tissue samples following an automated system harvest vectors transport the mitochondria for target cell incorporation by endocytosis. A newer treatment modality has now emerged flaring hopes of successful treatment in areas of cardiovascular domain with significant morbidity and mortality. In addition to cell based therapies that are emerging in the form of stem cells, cellular organelle transplantation now opens up the domain of sub cellular transplantation too.

Keywords: Subcellular Transplantation; Cardiac Ischaemia; Mitochondria

References

  1. Shin B., et al. “Mitochondrial transplantation in myocardial ischemia and reperfusion injury”. Advances in Experimental Medicine and Biology 982 (2017): 595-619.
  2. Emani SM., et al. “Autologous mitochondrial transplantation for dysfunctionafterischemiareperfusion injury”. The Journal of Thoracic and Cardiovascular Surgery1 (2017): 286-289.
  3. Kolata G. “Dying organs restored to life in novel experiments”. The New York Times (2018).
  4. Masuzawa A., et al. “Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury”. The American Journal of Physiology-Heart and Circulatory Physiology7 (2013): H966-H982.
  5. McCully JD., et al. “Injection of isolated mitochondria during early reperfusion for cardioprotection”. The American Journal of Physiology-Heart and Circulatory Physiology1 (2009): H94-H105.
  6. Cowan DB., et al. “Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection”. PLoS ONE8 (2016): e0160889.
  7. Kaza AK., et al. “Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion”. The Journal of Thoracic and Cardiovascular Surgery4 (2017): 934-943.
  8. Pacak CA., et al. “Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function”. Biol Open5 (2015): 622-626.
  9. Cowan DB., et al. “Transit and integration of extracellular mitochondria in human heart cells”. Scientific Reports1 (2017): 17450.
  10. Nasr VG., et al. “Association of hospital structure and complications with mortality after pediatric extracorporeal membrane oxygenation”. Pediatric Critical Care Medicine7 (2016): 684-691.
Citation: Pradeep Kumar Radhakrishnan., et al. “Subcellular Transplantation for Cardiac Ischaemia - The Exciting Future Unfolds”. EC Gynaecology 8.7 (2021): 01-03.

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