Research Article
Volume 8 Issue 6 - 2021
Therapeutic Thrombolysis of Mechanical Prosthetic Valve Thrombosis Using Reteplase: An Effective and Safe Treatment Modality
Ahamed Ali1*, Satyajit Samal1, Soumyaranjan Das1, Harpreet Singh Minhas2 and Muhammad Abid Geelani3
1Department of CTVS, GB Pant Hospital, New Delhi, India
2Professor, Department of CTVS, GB Pant Hospital, New Delhi, India
3Professor and head, Department of CTVS, GB Pant Hospital, New Delhi, India
*Corresponding Author: Ahamed Ali, Department of CTVS, GB Pant Hospital, New Delhi, India.
Received: May 06, 2021, 2021; Published: May 31, 2021


Objective: Emergency redo surgery for stuck valve or prosthetic valve thrombosis (PVT) has higher mortality rates and thrombolytic therapy has been proven effective treatment with different thrombolytic agents. In this study we evaluated the efficacy and safety profile of thrombolysis using Reteplase.

Materials and Methods: We retrospectively analyzed data of total 124 patients of stuck valve undergone thrombolysis between Jan 2013 t0 Dec 2020, after proper diagnostic evaluation at the time of presentation.

Results: The incidence of stuck valve was 3.65% with mean age of patients was 39.8 ± 11.9 years, mean interval from valve replacement surgery to episode of stuck valve was 4.9 ± 2.7 years. After thrombolysis, 71 (64.6%) patients had full range reopening of valve leaflets, 27 (24.5%) patients had partial reopening of leaflets, failed thrombolysis in 08 (7.3%) patients. As complications, 06 (5.4%) patients developed major bleeding, 16 (14.5%) patients developed minor bleeding, 08 (7.2%) patients developed cerebrovascular stroke and 04 (3.6%) patients expired.

Conclusion: Because of good efficacy, better safety, easy dosing Reteplase can be considered as an effective thrombolytic agent in patients with stuck bileaflet valve.

Keywords: Prosthetic Valve Thrombosis (PVT); Reteplase; Thrombolysis; Redo Surgery


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Citation: Ahamed Ali., et al. “Therapeutic Thrombolysis of Mechanical Prosthetic Valve Thrombosis Using Reteplase: An Effective and Safe Treatment Modality”. EC Cardiology 8.6 (2021): 75-81.

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