Research Article
Volume 8 Issue 3 - 2021
Tachyarrhythmias in COVID19 Patients: A Systematic Review and Meta-Analysis
Hilaryano Ferreira1*, Tchitchamene Nelumba2 and Humberto Morais3
1Department of Cardiology, Hospital Professor Doutor Fernando Fonseca, Lisbon, Portugal
2Department of Paediatric Cardiology, Hospital Santa Cruz, Lisbon, Portugal
3Department of Cardiology, Hospital Militar Principal/Instituto Superior, Luanda, Angola
*Corresponding Author: Hilaryano Ferreira, Department of Cardiology, Hospital Professor Doutor Fernando Fonseca, Lisbon, Portugal.
Received: January 26, 2021; Published: February 18, 2021


Background: Studies have shown that cardiovascular disease is associated with an increased risk of mortality in patients with COVID-19. The incidence of tachyarrhythmias and how it affects prognosis is not well determined. This systematic review and meta-analysis aimed to evaluate the incidence of tachyarrhythmias in patients with COVID-19 and their implications on patient prognosis.

Methods: We performed a search PubMed, and BVS Salud databases. The primary endpoint of the study was poor outcomes including mortality, tachyarrhythmias, and COVID-19.

Results: A total of 6 studies including 2232 patients were analyzed. The incidence of tachyarrhythmias in patients with COVID-19 was 7.9% (95% CI: 15.39, 143.26; I2: 0%). Supraventricular tachycardia was common, occurring in 5% (OR: 40.79, [95% CI: 11.18, 148.83, I2: 0%]). All-cause mortality had an (OR: 27.96, [95% CI: 7.59, 102.98, I2: 37%]) and arrhythmia-related mortality had an (OR: 4.21, [95% CI: 0.91, 19.45, I2: 8%]).

Conclusion: Tachyarrhythmia incidence and tachyarrhythmia-related mortality appears to be low in patients with COVID-19.

Keywords: Arrhythmias; Covid-19; Rhythm; Disorders; SARS-CoV-2; Cardiovascular Disease


    1. World Health Organization. “Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020” (2020).
    2. Wu Z and McGoogan JM. “Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention”. The Journal of the American Medical Association 13 (2020): 1239-1242.
    3. Cui Y., et al. “A 55-Day-Old female infant infected with 2019 novel coronavirus disease: Presenting with pneumonia, liver injury, and heart damage”. The Journal of Infectious Diseases 11 (2020): 1775-1781.
    4. Jiehao C., et al. “A Case Series of Children With 2019 Novel Coronavirus Infection: Clinical and Epidemiological Features”. Clinical Infectious Diseases 6 (2020): 1547-1551.
    5. Petrilli CM., et al. “Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study”. BMJ (2020).
    6. Moher D., et al. “Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement”. Annals of Internal Medicine 151 (2009): 264-269.
    7. Le Floch B., et al. “Which positive factors determine the GP satisfaction in clinical practice? A systematic literature review”. BMC Family Practice 17 (2016): 133.
    8. Cipriani A., et al. “Arrhythmic profile and 24-hour QT interval variability in COVID-19 patients treated with hydroxychloroquine and azithromycin”. International Journal of Cardiology 316 (2020): 280-284.
    9. Chen Q., et al. “Cardiovascular manifestations in severe and critical patients with COVID-19”. Clinical Cardiology 7 (2020): 796-802.
    10. Wang D., et al. “Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China”. The Journal of the American Medical Association 11 (2020): 1061-1069.
    11. Bhatla A., et al. “COVID-19 and cardiac arrhythmias”. Heart Rhythm9 (2020): 1439-1444.
    12. Si D., et al. “Death, discharge and arrhythmias among patients with COVID-19 and cardiac injury”. Canadian Medical Association Journal 28 (2020): E791-E798.
    13. Samuel S., et al. “Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval”. Heart Rhythm11 (2020): 1960-1966.
    14. Lakkireddy DR., et al. “Guidance for Cardiac Electrophysiology During the COVID-19 Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association Circulation 141.21 (2020): e823-e831.
    15. Pranata R., et al. “Incidence and impact of cardiac arrhythmias in coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis”. Indian Pacing and Electrophysiology Journal 5 (2020): 193-198.
    16. Liao S-C., et al. “Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients”. Critical Care 1 (2020): 690.
    17. Goyal P., et al. “Clinical Characteristics of Covid-19 in New York City”. The New England Journal of Medicine 24 (2020): 2372-2374.
    18. Cho Jae Hyung., et al. “Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States”. PLoS One 12 (2020): e0244533.
    19. Peretto G., et al. “Ventricular Arrhythmias in Myocarditis: Characterization and Relationships With Myocardial Inflammation”. Journal of the American College of Cardiology 9 (2020): 1046-1057.
    20. Richardson S., et al. “Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area”. The Journal of the American Medical Association 20 (2020): 2052-2059.
    21. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet10223 (2020): 497-506.
    22. Shi S., et al. “Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China”. JAMA Cardiology 7 (2020): 802-810.
Citation: Hilaryano Ferreira., et al. “Tachyarrhythmias in COVID19 Patients: A Systematic Review and Meta-Analysis”. EC Cardiology 8.3 (2021): 14-21

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 15, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.