Review Article
Volume 8 Issue 1 - 2021
Cardiogenic Dementia: The Role of Chronic Cerebral Hypoperfusion in Cardiogenic Dementia and Cognitive Impairment in Patients with Cardiovascular Diseases
Nicholas A Kerna1,2*, Kevin D Pruitt3, Kyle Kadivi4, Uzoamaka Nwokorie5, Olufemi Odugbemi6, Oluwatosin A Atolagbe7, Shain Waugh8 and Emmanuella Solomon9
1SMC–Medical Research, Thailand
2First InterHealth Group, Thailand
3Kemet Medical Consultants, USA
4Global Health Group LLC, USA
5University of Washington, USA
6Olabisi Onabanjo University, Nigeria
7Zorvis Inc., USA
8Fettle Path, USA
9Obafemi Awolowo University, Nigeria
*Corresponding Author: Nicholas A Kerna, SMC-Medical Research, Thailand.
Received: November 30, 2020; Published: December 31, 2020


The relationship between the brain and heart has been suspected and alluded to for several millennia. More recently, studies have associated low cardiac functioning with a decline in cognitive ability and established a link between vascular risk determinants and dementia. Cognitive function is dependent on several factors, which affect hemodynamic function and cardiac disease progression, contributing to cognitive decline (termed, cardiogenic dementia). Poor perfusion of cerebral tissues (termed, cerebral hypoperfusion) can adversely affect cognitive function, resulting in reduced attention span and memory. A dysfunction in cerebral autoregulation and neurometabolic inadequacy have been implicated in cognitive decline. Recently, specific treatment, namely cardiac resynchronization, is advancing enhancements in cardiac functioning in patients with symptomatic heart failure by improving cardiac hemodynamics and ejection fractions, resulting in improved executive functioning, global cognition, and visuospatial performance. However, at this time, studies on the efficacy of cardiac resynchronization and lessening the effects of cardiogenic dementia are limited.

Keywords: Alzheimer’s Disease; Cerebral hyperperfusion; Cognitive Decline; Dementia; Proteinopathy; Revascularization


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Citation: Kerna NA, Pruitt KD, Kadivi K, Nwokorie U, Odugbemi O, Atolagbe OA, Waugh S, Solomon E. “Cardiogenic Dementia: The Role of Chronic Cerebral Hypoperfusion in Cardiogenic Dementia and Cognitive Impairment in Patients with Cardiovascular Diseases”. EC Cardiology 8.1 (2021): 47-53.

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