Research Article
Volume 7 Issue 12 - 2020
Regulative Effect by Fermented Herbal Derivatives for Prolonged Fatigue Monitored by Herpes Virus Copies in Human
Daisuke Sakamoto1, Yasuhiro Nagayoshi1, Nobuo Yamaguchi2* and Shigeru Sakamoto1
1Department of Cardiovascular Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
2Ishikawa Natural Medicinal Products Research Center, Foundation, Fukubatake, Kanazawa, Ishikawa, Japan
*Corresponding Author: Nobuo Yamaguchi, Professor Emeritus, Department of Immunology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Received: October 10, 2020; Published: November 30, 2020


Introduction: Prolong fatigue is a common among young and older adults, yet, only a small percentage of affected individuals seek medical attention. Several studies have described complementary and alternative medicine as effective strategies for improving fatigue. The aim of this study was to evaluate the effect of a fermented herbal derivatives (FHD) on prolonged fatigue lasting less than 12 months.

Methods: In this trial, participants with prolonged fatigue lasting 1 - 6 months were randomly allocated into two groups: experimental group (FHD group, n=10) and a control group (C group, n = 9). The FHD group consumed once a day for 9 months, whereas the control group did not. Outcomes were assessed at baseline, 3 month, 6 month and 9 month. The primary outcome was fatigue severity as measured by the gene copy of herpes simplex virus. Secondary outcomes included sleep quality, depression symptoms, and quality of life as measured by the Pittsburgh Sleep Quality Index, respectively.

Results: Of 20 individuals screened, 19 completed the study. The mean change in fatigue severity was significantly larger in the FHD group than in the C group at 6 months and improvements in fatigue severity were maintained at 9 month follow-up. Sleep quality was also significantly improved in the FHD group at 6 and 9 months. There were no statistically significant changes in depression, quality of life, or liver and renal parameters during the experimental period.

Conclusion: The present results suggest that the fermented herbal decoction reduces fatigue severity and improves sleep quality in both young and older ager with prolonged fatigue.

Keywords: Fermented Herbal Decoction; Prolonged Fatigue; Herpes Simplex Virus


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Citation: Nobuo Yamaguchi., et al. “Regulative Effect by Fermented Herbal Derivatives for Prolonged Fatigue Monitored by Herpes Virus Copies in Human”. EC Cardiology 7.12 (2020): 61-70.

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