Case Report
Volume 7 Issue 12 - 2020
Multiple Unruptured Sinus of Valsalva Aneurysms Involving Right and Left Aortic Sinuses and Presenting as Severe Aortic Regurgitation
Humberto Morais*
Department of Cardiology, Hospital Militar Principal/Instituto Superior, Luanda, Angola
*Corresponding Author: Humberto Morais, Department of Cardiology, Hospital Militar Principal/Instituto Superior, Luanda, Angola.
Received: October 05, 2020; Published: November 25, 2020


Sinus of Valsalva aneurysms (SVAs) is a rare but well-known defect of the aortic root. An even greater rarity is the presence of multiple unruptured aneurysms in the same patient. Unruptured SVAs is asymptomatic usually and often found incidentally. However, the condition can manifest by distortion or compression of adjacent structures as right ventricular outflow tract obstruction, aortic insufficiency, tricuspid stenosis and regurgitation, myocardial ischemia or infarction, conduction disturbances, mediastinal mass, thromboembolism and rupture. The diagnostic modalities include transthoracic and transesophageal echocardiography, multidetector computed tomography, magnetic resonance imaging angiography and cardiac catheterization. Surgical repair of unruptured SVAs should be advised in symptomatic cases.

The author describe a case of multiple unruptured SVAs involving right and left aortic sinuses presenting with signs and symptoms of congestive heart failure, due to a severe aortic regurgitation in a 25-year-old female who underwent successful surgical repair.

Keywords: Sinus of Valsalva Aneurysm; Echocardiography; Computed Tomography; Aortic Regurgitation


  1. Morais H., et al. “Unruptured congenital aneurysm of the sinus of Valsalva in an African population: a six-year experience at an echocardiography laboratory”. The Cardiovascular Journal of Africa 3 (2009): 192-195.
  2. Vijay B A., et al. “Surviving all odds: A unique case of multiple congenital unruptured sinus of Valsalva aneurysms involving both left and right coronary sinuses with biventricular dysfunction and heart block”. Case Reports in Cardiology (2016): 4654031.
  3. Chigurupati K., et al. “Multiple unruptured aortic sinus of Valsalva aneurysms: A rare presentation”. Echocardiography2 (2017): 317-319.
  4. Reddy SM. “Surgical repair of multiple unruptured aneurysms of sinus of Valsalva”. Interactive CardioVascular and Thoracic Surgery 4 (2009): 709-711.
  5. Goldberg N and Krasnow N. “Sinus of Valsalva aneurysms”. Clinical Cardiology 12 (1990): 831-836.
  6. Omeh DJ and Makaryus AN. “Unruptured multiple sinus of Valsalva aneurysms”. Radiology Case Reports (2020): 5046095.
  7. Chung E., et al. “A Case of Unruptured Aneurysm of the Right Sinus of Valsalva with Right Ventricular Outflow Obstruction Korean”. Circulation Journal 4 (2014): 274-277.
  8. Wang B., et al. “Sinus of Valsalva aneurysm protruding into the mitral anterior leaflet causing dyspnea: A CARE-compliant case report”. Medicine48 (2019): e18169.
  9. Gibbs KL., et al. “Hemodynamic compromise (tricuspid stenosis and insufficiency) caused by an unruptured aneurysm of the sinus of Valsalva”. Journal of the American College of Cardiology 5 (1986): 1177-1181.
  10. Mørk SR., et al. “Giant unruptured aneurysm of the left coronary sinus of Valsalva presenting as acute coronary syndrome: a case report”. European Heart Journal - Case Reports 2 (2019): ytz053.
  11. Shahrabani RM and Jairaj PS. “Unruptured aneurysm of the sinus of Valsalva: a potential source of cerebrovascular embolism”. British Heart Journal 69 (1993): 266-267.
  12. Hussain S., et al. “Un-ruptured Non-Coronary Sinus of Valsalva Aneurysm with Complete Heart Block”. Pakistan Journal of Medical Sciences 6 (2017): 1531-1533.
  13. Xu B., et al. “Sinus of Valsalva Aneurysms: A State-of-the-Art Imaging Review”. American Society of Echocardiography 3 (2002): 295-312.
  14. Hanna MF., et al. “Cross-sectional imaging of sinus of Valsalva aneurysms: lessons learned”. Diagnostic and Interventional Radiology 5 (2017): 339-346.
  15. Morais H., et al. “Rupture of right sinus of Valsalva aneurysm into right cardiac chambers: The role of different imaging modalities”. Journal of Cardiovascular Ultrasound 1 (2016): 84-86.
Citation: Humberto Morais. “Multiple Unruptured Sinus of Valsalva Aneurysms Involving Right and Left Aortic Sinuses and Presenting as Severe Aortic Regurgitation”. EC Cardiology 7.12 (2020): 44-48.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 21, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.