Review Article
Volume 7 Issue 11 - 2020
Comparison of the New Generation Edwards Sapien 3 Valve and Sapien XT for Transcatheter Aortic Valve Replacement (TAVR)
Bahaa Alhabil*, Alain Dibie, Nicolas Amabile, François Philippe, Aurélie Veugeois, Luc Drieu and Christophe Caussin
Cardiology Department, Institut Mutualiste Montsouris, Paris, France
*Corresponding Author: Bahaa Alhabil, Cardiology Department, Institut Mutualiste Montsouris, Boulevard Jourdan, Paris, France.
Received: August 12, 2020; Published: October 09, 2020




Abstract

Background: The new balloon-expandable valve Edwards Sapien 3 provide a superiority over previous device, in a broader range of patients, with better accuracy in valve positioning and less paravalvular regurgitation. We aimed to evaluate periprocedural and short-term outcomes using the Sapien 3 compared with the earlier generation Sapien XT prosthesis.

Methods: A single center prospective study included 142 consecutive patients who underwent TAVR with SAPIEN device between January 2013 and March 2015 (n = 76 SXT and n = 66 S3). Valve Academic Research Consortium endpoints were used.

Results: Sapien 3 patients had a higher prevalence of peripheral arterial disease and ilio-femoral axis calcifications on CT scan. Device implantation success rate was higher in the Sapien 3.The prevalence of moderate to severe paravalvular leak was lower in Sapien 3 patients (0% vs 9.2%, p = 0.01), as well as, the incidence of life-threatening and major bleeding events (1,5% vs 13,1%, p = 0.02). There was no difference regarding the 30-days rate of MACCE between patients, including death (3% vs. 5%), stroke (3% vs. 2.6%) and major vascular complications (6% vs. 8%).

Conclusion: Sapien 3 valve allows TAVR in patients with more severe peripheral artery disease with lower rate of paravalvular regurgitations and major bleeding compared with Sapien XT.

Keywords: Edwards Sapien 3; Transcatheter Aortic Valve Replacement (TAVR); Aortic Stenosis

References

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Citation: Bahaa Alhabil., et al. “Comparison of the New Generation Edwards Sapien 3 Valve and Sapien XT for Transcatheter Aortic Valve Replacement (TAVR)”. EC Cardiology 7.11 (2020): 01-10.

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