Mini Review
Volume 7 Issue 8 - 2020
Oxidative Stress Cardiac Autonomic Neuropathy: A Unifying Paradigm in Adult Sudden Death with Normal Left Ventricular Ejection Fraction; Early Diagnosis and Treatment Reduces Sudden Death at Least 43%
Gary L Murray*
Director of Research, The Heart and Vascular Institute, Germantown, TN, USA
*Corresponding Author: Gary L Murray, Director of Research, The Heart and Vascular Institute, Germantown, TN, USA.
Received: June 17, 2020; Published: July 29, 2020


This commentary on our current paradigms’ inability to predict and prevent sudden cardiac death (SCD), responsible for 15 - 20% of all deaths in the general population, is inspired by the results of our 12 year study of 133 type II diabetics (DM) in whom we identified SCD risk with one autonomic screening and addressed it, reducing SCD 43% (p = 0.0076). We are currently ascertaining if this applies to non-diabetics. The SCD reduction in DMII was due to screening and treating even mild (69% of patients) oxidative cardiac autonomic neuropathy. Since oxidative stress, and secondary dysautonomia, is a common thread of all major cardiac disease, and there is preventative therapy, a new paradigm of oxidative-stress cardiac dysautonomia as a major common final pathway to SCD should be considered. The general population should be screened autonomically and preventive measures initiated.

Keywords: Autonomic Nervous System; Alpha Lipoic Acid; Sudden Death


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Citation: Gary L Murray. “Oxidative Stress Cardiac Autonomic Neuropathy: A Unifying Paradigm in Adult Sudden Death with Normal Left Ventricular Ejection Fraction; Early Diagnosis and Treatment Reduces Sudden Death at Least 43%”. EC Cardiology 7.8 (2020): 68-72.

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