Research Article
Volume 3 Issue 1 - 2020
The Use of Piracetam and Cerebrolysin in the Treatment of Agenesis of Corpus Callosum with Colpocephaly
Aamir Jalal Al Mosawi1,2*
1Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City, Baghdad, Iraq
2Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq
*Corresponding Author:Aamir Jalal Al Mosawi, Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City and Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq.
Received: October 30, 2019; Published: December 23, 2019




Abstract

Background: Corpus callosum is a large nerve tract consisting of a flat bundle of commissural fibers that runs below the brain cerebral cortex. It connects the left and right cerebral hemispheres. Absence of the corpus callosum because of failure of development is a rare congenital defect called “Agenesis of the corpus callosum”.

Patients and Methods: Two Iraqi infants with non-syndromic agenesis of the corpus callosum were observed. One infant had the isolated type and the second infant had agenesis of the corpus callosum associated with colpocephaly. 

Both infants had the clinical features of the syndrome resulting from the associated failure of neuronal migration including hypotonia with poor head control, no response to voice, not recognizing faces, and they didn’t show any eye contact. They have never smiled and had poor spontaneous movements. 

The patient with colpocephaly was a girl and, she was treated with courses of intramuscular piracetam and cerebrolysin for three months with aim of improving brain functions and accelerating her development. The second patient was a boy and he didn’t receive any specific therapy.

Results: Treatment was not associated with any side effects, and after three months of treatment, the patient experienced improvements in feeding, muscle tone, alertness and response to voice, and movements.

The untreated patient didn’t show any obvious improvement despite he didn’t have colpocephaly.

Conclusion: Further studies enrolling a larger number of patients are recommended.

Keywords: Corpus Callosum Agenesis; Colpocephaly; Piracetam; Cerebrolysin Treatment

References

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  12. Chen CC., et al. “Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study”. British Journal of Neurosurgery 27.6 (2013): 803-807.
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Citation: Aamir Jalal Al Mosawi. “The Use of Piracetam and Cerebrolysin in the Treatment of Agenesis of Corpus Callosum with Colpocephaly”. EC Clinical and Medical Case Reports 3.1 (2020): 01-05.

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