Abstract

A patient with typical NK/T lymphoma of nasal type was treated with parenteral thiamin 100 mg twice a day plus 1 ampule of vitamin B complex for 10 days. Nasal signs and fever greatly improved. Then thiamin increased as 200 mg twice daily for next 4 months. Nasal signs including fever disappeared, daily farming and driving restored, and lab test greatly improved. However, the patient erroneously believed to be well cured and discontinued parenteral vitamins for 3 months. Totally, the patient was getting free from signs and symptoms for 7 months. Nasal signs then returned and chemo- and radiotherapy were held, January 5-15, 2013. Within 2 months, oral palate entirely perforated. He became extremely powerless and confined to bed until his death, June 29, 2013.

Keywords: Baker’s Cyst; Lipoma; Lymphoma; Osteosarcoma; Submandibular Gland Cyst; Thiamin

References

1. Lee BY and Thurmon TF. “Nutritional disorders in a concentration camp”. Journal of American College of Nutrition 16.4 (1997): 366-375.
2. Lee BY., et al. “Review of thiamin therapy for space occupying lesions”. Scholar Journal of Applied Sciences and Research 2.10 (2019): 29-34.
3. Lee BY and Bai JH. “Nutritional New Diseases and New Concepts”. Chapter 4, Tissue Enlargements in Malnutrition, KF Times Group Inc, USA (2017): 52.
4. Cascante M., et al. “Role of thiamin (vitamin B1) and transketolase in tumor cell proliferation”. Nutrition and Cancer 36 (2000): 150-154.
5. Boros LG., et al. “Thiamin supplementation to cancer patients: a double edged sword”. Anticancer Research 18.1 (1998): 595-602.
6. Lee BY., et al. “Thiamin deficiency: a possible major etiology of some tumors?” Oncol Reports 14 (2005): 1589-1592.
7. Zashe JA., et al. “Linking vitamin B1 with cancer cell metabolism”. Cancer and Metabolism 1 (2013): 16.
8. Sweet RL and Zashe JA. “HIF1-alpha-mediated gene expression induced by VB1 deficiency”. International Journal for Vitamin and Nutrition Research 83.3 (2013): 188-197.
9. Hanberry BS., et al. “High dose VB1 reduces proliferation in cancer cell lines analogous to dichloracetate”. Cancer Chemotherapy and Pharmacology 73 (2014): 585-594.
10. Luong KV and Nguyen LT. “The role of thiamin in cancer, possible genetic cellular signaling mechanisms”. Cancer Genomics Proteomics 10.4 (2013): 169-185.
11. Tuynes AJ. “A case-control study on colorectal cancer in Belgium. Preliminary results”. Sozial Und Praventimedzin 31 (1986): 81-82.
12. Slattery ML., et al. “Foods and colon cancer: an assessment of specific foods and their related nutrients (United States)”. Cancer Causes Control 8 (1997): 575-590.
13. Jedrychowski W., et al. “Alcohol consumption and the risk of colorectal cancer at low levels of micronutrient intake”. Medical Science Monitor 8 (2002): CR357-CR363.
14. Du S., et al. “Relationship between dietary nutrients intakes and human prostate cancer”. Public Health Research (Weisheng Yanjiu) 26 (1977): 122-125. 
15. Bidoli E., et al. “Micronutrients and ovarian cancer: a case-control study in Italy”. Annals of Oncology 12 (2001): 1589-1593.
16. Ireson J., et al. “The effect of a complex yeast preparation, as a food supplement, on the growth of Ehrlich’s ascites tumor in mice”. European Journal of Cancer 8 (1972): 159-166.
17. Bruce WR., et al. “Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats”. Cancer Letters 20 (2003): 125-129.
18. Shangari N., et al. “Toxicity of glyoxals - role of oxidative stress, metabolic detoxicification and thiamin deficiency”. Biochemical Society Transactions 31.6 (2000): 1390-1393.
19. Klaunig JE and Kamendulis LM. “The role of oxidative stress in carcinognensis”. Annual Review of Pharmacology and Toxicology 44 (2004): 239-267. 
20. Symons MC. “Radicals generated by bone cutting and fracture”. Free Radical Biology and Medicine 20 (1996): 831-835.
21. Thornalley PJ. “Review: Pharmacology of methylglyoxyal: Formation, modification of proteins and nucleic acids, and enzymatic detoxification- A role of pathogenesis and antiproliferative chemotherapy”. General Pharmacology 27 (1996): 565-573.
22. Takahashi M., et al. “Effect of glyoxal and methylglyoxal administration on gastric carcinogenesis in Wistar rats after initiation with N-methyl-N’-nitro-N- nitrosoguanidine”. Carcinogenesis 1989 10 (1989): 1925-1927.
23. Singh R., et al. “Advanced glycation end-products: a review”. Diabetologia 44 (2001): 129-146.
24. Thornalley PJ., et al. “Suppresssion of the accumulation of triosephosphates and increased formation of methyglyoxal in human red blood cells during hyperglycemia by thiamin in vitro”. Journal of Biochemistry 129 (2001): 543-549.
25. La Selva M., et al. “Thiamin corrects delayed replication and decreases production of lactate and advanced glycation end products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose condition”. Diabetologia 96 (1996): 1263-1268.
26. Brownlee M. “Biochemistry and molecular cell biology of diabetic complications”. Nature 414 (2001): 813-820.
27. Hammes HP., et al. “Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy”. Nature Medicine 9 (2003): 4-299.
28. Obrenovich ME and Monnier VM. “Vitamin B1 blocks damage caused by hyperglycemia”. Sci Aging Knowledge Envirn 10 (2003): PE6.