Review Article
Volume 5 Issue 7 - 2022
A Comprehensive Review of Stem Cells and Applications in Specific Diseases and Regenerative Therapy

John V Flores1,2, Nicholas A Kerna3,4, Sudeep Chawla5, ND Victor Carsrud6, Hilary M Holets1,2, Stephen M Brown7, Kevin D Pruitt8,9, Uzoamaka Nwokorie10, Dabeluchi Ngwu Onyejerebechi Florence11 and Nkiru J Obi 12

1Beverly Hills Wellness Surgical Institute, USA

2Orange Partners Surgicenter, USA

3SMC–Medical Research, Thailand

4First InterHealth Group, Thailand

5Chawla Health & Research, USA

6Lakeline Wellness Center, USA

7International University of Health Sciences, St. Kitts

8Kemet Medical Consultants, USA

9PBJ Medical Associates, LLC, USA

10University of Washington, USA

11Federal Medical Centre, Owerri, Imo State, Nigeria

12Washington University, USA

*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500. Contact: medpublab+drkerna@gmail.com.
Received: March 24, 2022; Published: June 30, 2022




Abstract

Stem cells (SCs) are undifferentiated progenitor cells present in multicellular organisms. They have the remarkable capacity to proliferate and differentiate into a wide range of various types of specialized cells. SC treatment has emerged as a intriguing research topic and opportunity for new therapies. The phenomenal breakthrough in SC research has provided the groundwork for cell-based therapeutics for diseases that traditional drugs cannot manage, such as ophthalmic disorders. Excellent outcomes have also been achieved in managing potential chronic medical diseases, such as diabetes and cardiomyopathy. SCs represent the frontiers of tissue regeneration due to their capacity for self-renewal and ability to develop into various types of cells. Clinical studies involving SC-based therapeutics have advanced at an exponential rate in recent years. Since their discovery, improvements in SC research have been irregular; and many issues restrict their utility. Nonetheless, breakthroughs have occurred in understanding their molecular genetics. These challenges concern not just tumor development in animal studies and transplant rejection, but also ethical and social considerations surrounding the use of embryonic cells. This comprehensive review of the history of SC research includes notable milestones that have been achieved in the growth of this crucial field of biomedicine.

Keywords: Stem Cells (SCs); Specific Diseases; Regenerative Therapy

References

  1. TJ Stemcell. “Transplantation- Types, Risks and Benefits”. The Journal of Stem Cell Research and Therapy03 (2011). https://www.walshmedicalmedia.com/open-access/stemcell-transplantation-types-risks-and-benefits-2157-7633.1000114.pdf
  2. Shihadeh H. “History and recent advances of Stem Cell Biology and the implications for human health”. Digital Commons@URI (2022). https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1432&context=srhonorsprog
  3. Zakrzewski W., et al. “Stem cells: past, present, and future”. The Journal of Stem Cell Research and Therapy1 (2019): 68. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1165-5
  4. Charitos IA., et al. “Stem cells: A historical review about biological, religious, and ethical issues”. Stem Cells International (2021): 9978837. https://www.hindawi.com/journals/sci/2021/9978837/
  5. Ballini A., et al. “Stemness genes expression in naïve vs. osteodifferentiated human dental-derived stem cells”. European Review for Medical and Pharmacological Sciences7 (2019): 2916-2923. https://pubmed.ncbi.nlm.nih.gov/31002142/
  6. Girlovanu M., et al. “Stem cells - biological update and cell therapy progress”. Clujul Medical3 (2015): 265-271. https://pubmed.ncbi.nlm.nih.gov/26609255/
  7. Thomson JA., et al. “Embryonic stem cell lines derived from human blastocysts”. Science5391 (1998): 1145-1147. https://pubmed.ncbi.nlm.nih.gov/9804556/
  8. Boccellino M., et al. “Steroids and growth factors in oral squamous cell carcinoma: useful source of dental-derived stem cells to develop a steroidogenic model in new clinical strategies”. European Review for Medical and Pharmacological Sciences20 (2019): 8730-8740. https://pubmed.ncbi.nlm.nih.gov/31696459/
  9. Ballen KK., et al. “Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation”. Biology of Blood and Marrow Transplantation4 (2015): 688-695. https://pubmed.ncbi.nlm.nih.gov/25543094/
  10. Colman A. “Profile of John Gurdon and Shinya Yamanaka, 2012 Nobel laureates in medicine or physiology”. Proceedings of the National Academy of Sciences of the United States of America15 (2013): 5740-5741. https://www.pnas.org/doi/10.1073/pnas.1221823110
  11. Barzegar M., et al. “Potential therapeutic roles of stem cells in ischemia-reperfusion injury”. Stem Cell Research101421 (2019): 101421. https://pubmed.ncbi.nlm.nih.gov/30933723/
  12. EL Barky AR., et al. “Stem Cells, Classifications and their Clinical Applications”. American Journal of Pharmacology and Toxicology1 (2017): 001-007. https://pubmed.ncbi.nlm.nih.gov/16266332/
  13. Mahla RS. “Stem cells applications in regenerative medicine and disease therapeutics”. International Journal of Cell Biology (2016): 6940283. https://www.hindawi.com/journals/ijcb/2016/6940283/
  14. Zhang B and Wolynes PG. “Stem cell differentiation as a many-body problem”. Proceedings of the National Academy of Sciences of the United States of America28 (2014): 10185-10190. https://www.pnas.org/doi/10.1073/pnas.1408561111
  15. Stem Cell Differentiation | Stem Cells | Tocris Bioscience (2022). https://www.tocris.com/cell-biology/stem-cell-differentiation
  16. Lomax GP., et al. “Regulated, reliable, and reputable: Protect patients with uniform standards for stem cell treatments”. Stem Cells Translational Medicine5 (2020):547-553. https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.19-0377
  17. Galvez-Martin P., et al. “Mesenchymal stem cells as therapeutic agents: Quality and environmental regulatory aspects”. Stem Cells International (2016): 9783408. https://pubmed.ncbi.nlm.nih.gov/27999600/
  18. Center for Biologics Evaluation, Research. Tissue establishment registration. U.S. Food and Drug Administration (2021).
  19. Van Der Sanden B., et al. “Optimizing stem cell culture”. Journal of Cellular Biochemistry4 (2010): 801-807. https://pubmed.ncbi.nlm.nih.gov/20803548/
  20. Stem Cell quick guide: Stem Cell basics. Ucdavis.edu (2022).
  21. Cedar SH. “The function of stem cells and their future roles in healthcare”. The British Journal of Nursing2 (2006): 104-107. https://www.researchgate.net/publication/7284544_The_function_of_stem_cells_and_their_future_roles_in_healthcare
  22. Van Pham P. “Stem cell drugs: the next generation of pharmaceutical products”. Biomedical Research and Therapy10 (2016). http://www.bmrat.org/index.php/BMRAT/article/view/128
  23. Rouf M and Karnain O. “Stem cells and their potential therapeutic applications”. International Journal of Advanced Research in Biological Sciences4 (2016): 63-70. http://www.bmrat.org/index.php/BMRAT/article/view/128
  24. Noguchi H., et al. “Induction of expandable tissue-specific progenitor cells from human pancreatic tissue through transient expression of defined factors”. Molecular Therapy Methods and Clinical Development 13 (2019): 243-252. https://pubmed.ncbi.nlm.nih.gov/30828587/
  25. Navaei T., et al. “Nanoengineering of stem cells for musculoskeletal regeneration”. In: Nanoengineering in Musculoskeletal Regeneration. Elsevier (2020): 159-196. https://www.elsevier.com/books/nanoengineering-in-musculoskeletal-regeneration/razavi/978-0-12-820262-3
  26. Khalid K., et al. “Stem cell therapy and its significance in HIV infection”. Cureus8 (2021): e17507. https://www.nature.com/articles/d41586-019-00798-3
  27. Hütter G. “Stem cell transplantation in strategies for curing HIV/AIDS”. AIDS Research and Therapy1 (2016). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020531/
  28. Hütter G., et al. “Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation”. The New England Journal of Medicine7 (2009): 692-698. https://pubmed.ncbi.nlm.nih.gov/19213682/
  29. Allers K and Schneider T. “CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy”. Current Opinion in Virology 14 (2015): 24-29. https://pubmed.ncbi.nlm.nih.gov/26143158/
  30. Brown TR. “I am the Berlin patient: a personal reflection”. AIDS Research and Human Retroviruses1 (2015): 2-3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287108/
  31. Moyer CA and Mustafa A. “Drivers and deterrents of facility delivery in sub-Saharan Africa: a systematic review”. Reproductive Health1 (2013): 40. https://reproductive-health-journal.biomedcentral.com/articles/10.1186/1742-4755-10-40
  32. Zhang CL., et al. “Stem cells in cancer therapy: opportunities and challenges”. Oncotarget43 (2017): 75756-75766. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650462/
  33. Palop JJ., et al. “Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer’s disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling”. Methods in Molecular Biology 670 (2011): 245-262. https://pubmed.ncbi.nlm.nih.gov/20967595/
  34. Ong HT., et al. “Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth”. The Journal of Hepatology5 (2013): 999-1006. https://pubmed.ncbi.nlm.nih.gov/23867315/
  35. Stem cell research a guide to using small molecules product guide | Edition 2 (2022).
  36. Takahashi K and Yamanaka S. “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors”. Cell4 (2006): 663-676. https://pubmed.ncbi.nlm.nih.gov/16904174/
  37. Takahashi K., et al. “Induction of pluripotent stem cells from adult human fibroblasts by defined factors”. Cell5 (2007): 861-872. https://pubmed.ncbi.nlm.nih.gov/18035408/
  38. Huangfu D., et al. “Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds”. Nature Biotechnology7 (2008): 795-797. https://pubmed.ncbi.nlm.nih.gov/18568017/
  39. Stem Cell Transplantation | Leukemia and Lymphoma Society (2022). https://www.lls.org/treatment/types-treatment/stem-cell-transplantation
  40. Lennard AL. “Stem cell transplantation”. Western Journal of Medicine1 (2001): 42-46. https://www.lls.org/treatment/types-treatment/stem-cell-transplantation
  41. Allen SR and Wright A. “Stem cell therapy for knee osteoarthritis: a narrative review of a rapidly evolving treatment with implications for physical therapy management”. Physical Therapy Reviews1-2 (2019): 44-50. https://www.tandfonline.com/doi/abs/10.1080/10833196.2019.1585674
  42. Busse DMD. “Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells”. Pain Physician5-3 (2008): 343-353. https://pubmed.ncbi.nlm.nih.gov/18523506/
  43. Spasovski D., et al. “Intra-articular injection of autologous adipose-derived mesenchymal stem cells in the treatment of knee osteoarthritis”. Journal of Gene Medicine1 (2018): e3002. https://pubmed.ncbi.nlm.nih.gov/29243283/
  44. Yeh DC and Chan TM. “Therapeutics of stem cell treatment in anti-aging and rejuvenation”. The Stem Cell Discovery02 (2018): 13-31. https://www.scirp.org/journal/paperinformation.aspx?paperid=87258
  45. Prakoeswa CRS., et al. “The effects of amniotic membrane stem cell-conditioned medium on photoaging”. Journal of Dermatological Treatment5 (2019): 478-482. https://pubmed.ncbi.nlm.nih.gov/30265171/
  46. Fontes PA and Thomson AW. “Stem cell technology”. BMJ7220 (1999): 1308-1308. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129084/
  47. Aly RM. “Current state of stem cell-based therapies: an overview”. The Stem Cell Investigation 7 (2020): 8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367472/
  48. Shroff G and Gupta R. “Human embryonic stem cells in treating patients with spinal cord injury”. Annals of Neurosciences4 (2015): 208-216. https://pubmed.ncbi.nlm.nih.gov/26526627/
  49. Cheng A., et al. “Cartilage repair using human embryonic stem cell-derived chondroprogenitors: Human pluripotent stem cells for cartilage repair”. Stem Cells Translational Medicine11 (2014): 1287-1294. https://pubmed.ncbi.nlm.nih.gov/25273540/
  50. Mizutari K., et al. “Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma”. Neuron1 (2013): 58-69. https://pubmed.ncbi.nlm.nih.gov/23312516/
  51. Kuo BR., et al. “In vivo cochlear hair cell generation and survival by coactivation of β-catenin and Atoh1”. The Journal of Neuroscience30 (2015): 10786-10798. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518053/
  52. Cronk SM., et al. “Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy”. Stem Cells Translational Medicine5 (2015): 459-467. https://pubmed.ncbi.nlm.nih.gov/25769654/
  53. Mead B., et al. “Stem cell treatment of degenerative eye disease”. Stem Cell Research3 (2015): 243-257. https://www.sciencedirect.com/science/article/pii/S1873506115000306
  54. Gary Brown S., et al. “Adipose-derived stem cell therapy for severe muscle tears in working German shepherds: Two case reports”. The Stem Cell Discovery02 (2012): 41-44. https://www.researchgate.net/publication/272876924_Adipose-derived_stem_cell_therapy_for_severe_muscle_tears_in_working_German_shepherds_Two_case_reports
  55. Levit RD., et al. “Cellular encapsulation enhances cardiac repair”. Journal of the American Heart Association5 (2013): e000367. https://pubmed.ncbi.nlm.nih.gov/24113327/
  56. Lin BJ., et al. “Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration”. Journal of Materials Chemistry. B, Materials for Biology and Medicine3 (2016): 489-504. https://pubs.rsc.org/en/content/articlelanding/2016/tb/c5tb02265g
  57. Kaigler D., et al. “Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial”. Cell Transplant5 (2013): 767-777. https://pubmed.ncbi.nlm.nih.gov/22776413/
  58. Dye BR., et al. “In vitro generation of human pluripotent stem cell-derived lung organoids”. Elife (2015): 4. https://elifesciences.org/articles/05098
  59. Hanna J and Hubel A. “Preservation of stem cells”. Organogenesis3 (2009): 134-137. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781093/
  60. Mirabet V and Solves P. “Stem Cell Banking”. In: Regenerative Nephrology. Elsevier (2011): 409-420.
  61. Pamphilon D and Mijovic A. “Storage of hemopoietic stem cells”. Asian Journal of Transfusion Science2 (2007): 71-76. https://www.researchgate.net/publication/51661948_Storage_of_Hemopoietic_Stem_Cells
  62. Cyranoski D. “The potent effects of Japan’s stem-cell policies”. Nature7775 (2019): 482-485. https://link.gale.com/apps/doc/A600819355/AONE?u=googlescholar&sid=AONE&xid=531e4eb6
  63. Kurtzberg J., et al. “Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood”. Journal of Clinical Investigation10 (2005): 2592-2597. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236704/
  64. FDA Warns About Stem Cell Therapies | FDA (2022). https://www.fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapies
  65. Stem Cell or Bone Marrow Transplant Side Effects (2022).
  66. Lodi D., et al. “Stem cells in clinical practice: applications and warnings”. Journal of Experimental and Clinical Cancer Research1 (2011): 9. https://pubmed.ncbi.nlm.nih.gov/21241480/
  67. Stem Cell Therapy for Musculoskeletal Conditions.
  68. Lovell-Badge R. “The future for stem cell research”. Nature6859 (2001): 88-91. https://pubmed.ncbi.nlm.nih.gov/11689952/
  69. Kim KM and Evans GRD. “Tissue Engineering: The Future of Stem Cells”. The Journal of Tissue Science and Engineering1 (2001): 1-21. https://www.oulu.fi/spareparts/ebook_topics_in_t_e_vol2/abstracts/evans_0102.pdf
a href="https://pubmed.ncbi.nlm.nih.gov/33158718/">Ribeiro EM., et al. “Safety of coffee consumption after myocardial infarction: A systematic review andmeta-analysis”. Nutrition, Metabolism and Cardiovascular Diseases 30 (2020): 2146-2158. https://pubmed.ncbi.nlm.nih.gov/33158718/
  • Cornelis MC and El-Sohemy A. “Coffee, caffeine, and coronary heart disease”. Current Opinion in Clinical Nutrition and Metabolic Care 10 (2007): 745-751. https://pubmed.ncbi.nlm.nih.gov/17218826/
  • Citation: Flores JV, Kerna NA, Chawla S, Carsrud NDV, Holets HM, Brown SM, Pruitt KD, Nwokorie U, Florence DNO, Obi NJ. “A Comprehensive Review of Stem Cells and Applications in Specific Diseases and Regenerative Therapy”. EC Clinical and Medical Case Reports 5.7 (2022): 95-113.

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