Research Article
Volume 5 Issue 6 - 2022
Place of Rectal Indomethacin to Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Retrospective Study
Sanaa Berrag*, Salma Ouahid, Tarik Adioui, Fouad Nejjari and MounaTamzaourte

Department of Gastroenterology I, Military Hospital, Mohamed V University of Rabat, Rabat, Morocco

*Corresponding Author: Sanaa Berrag, Department of Gastroenterology I, Military Hospital, Mohamed V University of Rabat, Rabat, Morocco.
Received: April 19, 2022; Published: May 25, 2022


Introduction: Previous researches show that rectal indomethacin (RI) reduces the risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of this study was to evaluate the utility of RI in preventing PEP.

Methods: We conceived a retrospective study including 89 patients who underwent ERCP at the Military Hospital Mohamed V of Rabat-Morocco over a period of 3 years (January 2019 to April 2022). We collected clinical features and procedures details from patients’ records.

Results: A total of 89 patients were included for this study. PEP occurred in 12 of 89 (13,5%) patients. In the univariate analysis, the factors were associated with PEP are: administration of RI, pancreatic cannulation, difficult cannulation, number of pancreatic duct cannulation and the contrast injection into the pancreatic duct. In the multivariate analysis, when adjusting with other PEP risk factors, administration of RI and difficult cannulation were significantly associated with a higher risk of PEP. RI reduced the risk of PEP by 88% (OR 0.12, 95%CI 0.02 - 0.84, p = 0.03) and difficult cannulation increase the risk of PEP (OR = 3.97, 95%CI 0.71 - 0.84, p = 0.03).

Conclusion: Prophylactic rectal indomethacin significantly reduced the rates of PEP and should be administrated for all patients undergoing ERCP.


Keywords: Endoscopic Retrograde Cholangio-Pancreatography (ERCP); Rectal Indomethacin (RI); Pancreatitis (PEP)


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Citation: Sanaa Berrag., et al. “Place of Rectal Indomethacin to Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Retrospective Study”. EC Clinical and Medical Case Reports 5.6 (2022): 02-06.

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