Research Article
Volume 5 Issue 5 - 2022
Peptide Correction of Tissue Hypoxia in Diabetic Foot Syndrome
Trofimova S*, Khavinson V, Trofimov A and Ivko O

St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

*Corresponding Author: Trofimova S, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Received: March 28, 2022; Published: April 27, 2022


The problem of treating complications of diabetes mellitus continues to be a pressing issue in modern medicine. One of the complications of diabetes is diabetic foot syndrome. With this complication, a complex of anatomical and functional changes is observed, leading to the development of tissue ischemia (hypoxia), accompanied by increased trauma and infection of the soft tissues of the foot. It should be noted that such complications lead to early disability in patients, up to amputation of the foot and death. The use of the dipeptide bioregulator L-glutamic-L-tryptophanic acid (L-Glu-L-Trp) contributes to the activation of reparative processes in ischemic tissues of patients with diabetic foot syndrome by inhibiting the synthesis of the HIF 1α factor and, as a result, oxygenation of soft tissues.


Keywords: Diabetes Mellitus; Diabetic Foot; HIF 1 Factor, Dipeptide


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Citation: Trofimova S., et al. “Peptide Correction of Tissue Hypoxia in Diabetic Foot Syndrome”. EC Clinical and Medical Case Reports 5.5 (2022): 08-15.

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