Research Article
Volume 5 Issue 5 - 2022
Peptide Correction of Tissue Hypoxia in Diabetic Foot Syndrome
Trofimova S*, Khavinson V, Trofimov A and Ivko O

St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

*Corresponding Author: Trofimova S, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Received: March 28, 2022; Published: April 27, 2022




Abstract

The problem of treating complications of diabetes mellitus continues to be a pressing issue in modern medicine. One of the complications of diabetes is diabetic foot syndrome. With this complication, a complex of anatomical and functional changes is observed, leading to the development of tissue ischemia (hypoxia), accompanied by increased trauma and infection of the soft tissues of the foot. It should be noted that such complications lead to early disability in patients, up to amputation of the foot and death. The use of the dipeptide bioregulator L-glutamic-L-tryptophanic acid (L-Glu-L-Trp) contributes to the activation of reparative processes in ischemic tissues of patients with diabetic foot syndrome by inhibiting the synthesis of the HIF 1α factor and, as a result, oxygenation of soft tissues.

 

Keywords: Diabetes Mellitus; Diabetic Foot; HIF 1 Factor, Dipeptide

References

  1. Левина АА., et al. “Регуляция гомеостаза кислорода. Фактор, индуцированный гипоксией (hif) и его значение в гомеостазе кислорода”. Педиатрия 4 (2009): 92-97.
  2. Петленко ИС., et al. “ЭКСПЕРИМЕНТАЛЬНОЕ ИЗУЧЕНИЕ СПЕЦИФИЧЕСКОЙ АКТИВНОСТИ L-ГЛУТАМИЛ - L-ТРИПТОФАНА”. Современные проблемы науки и образования (2019): 3.
  3. Трофимова СВ and Мирошниченко МИ. “Оптимизация гериатрической помощи пациентам с синдромом диабетической стопы”. Электронный научный журнал «Геронтология» (2020).
  4. Bhat PJ., et al. “Can metabolic plasticity be a cause for cancer? Warburg-Waddington legacy revisited”. Clinical Epigenetics2 (2011): 113-122.
  5. Bowering CK. “Diabetic foot ulcers. Pathophysiology, assessment, and therapy”. Canadian Family Physician 47 (2001): 1007-1016.
  6. Khavinson VKh. “Peptides and Ageing”. Neuroendocrinology Letters3-144 (2002).
  7. Khavinson VKh., et al. “EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease”. This Special Issue of Molecules, Peptide Therapeutics1-159 (2021): 1-16.
  8. Khavinson VKh and Malinin VV. “Gerontological Aspects of Genom Peptide Regulation”. Basel (Switzerland): Karger AG (2005): 104.
  9. Kleopatra Alexiadou and John Doupis Management of Diabetic Foot Ulcers Diabetes Ther. 3.1 (2012): 4.
  10. Lauterbach S., et al. “Prevalence of diabetic foot syndrome and its risk factors in the UK”. Journal of Wound Care 19 (2010): 333-337.
  11. Lerman OZ., et al. “Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia”. The American Journal of Pathology 162 (2003): 303-312.
  12. Martin A., et al. “Abnormal angiogenesis in diabetes mellitus”. Medicinal Research Reviews 23 (2003): 117-145.
  13. McGarvey S., et al. “Emerging treatments for epidemic (AIDS-related) Kaposi’s sarcoma”. Current Opinion in Oncology5 (1998): 413-422.
  14. V Trofimova and Vladimir Kh Khavinson. “Rattan Suresh and Gurcharan Kaur, edition. Nutrition, Food and Diet in Ageing and Longevity Springer. 2021. (Healthy Ageing and Longevity) Chapter: Svetlana Role of Short Peptides as an Important Nutritional Element in Maintenance of Body Homeostasis 14 (2021): 491- 507.
  15. Sayed KhM and Mahmoud AA. “Heat shock protein-70 and hypoxia inducible factor-1α in type 2 diabetes mellitus patients complicated with retinopathy”. Acta Ophthalmologica5 (2016): 361-366.
  16. Semenza GL and Wang GL. “A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site 96 required for transcriptional activation”. Molecular and Cellular Biology 12 (1992): 5447-5454.
  17. Semenza GL. “Targeting HIF-1 for cancer therapy”. Nature Reviews Cancer 10 (2003): 721-732.
  18. Thangarajah H., et al. “HIF-1α dysfunction in diabetes”. Cell Cycle1 (2010): 75-79.
  19. Thangarajah H., et al. “The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues”. Proceedings of the National Academy of Sciences of the United States of America 106 (2009): 13505-13510.
  20. Trofimov АV., et al. “Medical preparation for enhancing tissue oxygenation in case of diabetic foot and use of it”. United States Patent № 16634973; US 2020/0237850 A1; Australia Patent № 280032, 2017439352; Canada Patent № 3,066,214; European Patent № 3 638 281 (2021).
  21. Trofimova SV. “Molecular Mechanisms of Retina Pathology and Ways of its Correction”. Springer Nature (2020): 148.
  22. Trofimova SV., et al. “Medicinal Peptide Drugs: A Promising Direction in Modern Pharmacology”. EC Clinical and Medical Case Reports3 (2022): 17-24.
  23. Tulpule A., et al. “Results of a randomized study of IM862 nasal solution in the treatment of AIDS related Kaposi’s sarcoma”. Journal of Clinical Oncology4 (2000): 716-723.
  24. Vanyushin BF and Khavinson V.Kh. “Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity / W. Doerfler, P. Böhm (editions.). Epigenetics - A Different Way of Looking at Genetics”. Springer International Publishing Switzerland (2016): 69-90.
  25. Wenger RH. “Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression”. The FASEB Journal 16 (2002): 1151-1162.
  26. Yan HT and Su GF. “Expression and significance of HIF-1α and VEGF in rats with diabetic retinopathy”. Asian Pacific Journal of Tropical Medicine 7 (2014): 237-240.
  27. Ziello JE., et al. “Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia”. Yale Journal of Biology and Medicine2 (2007): 51-60.
Citation: Trofimova S., et al. “Peptide Correction of Tissue Hypoxia in Diabetic Foot Syndrome”. EC Clinical and Medical Case Reports 5.5 (2022): 08-15.

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