Review Article
Volume 5 Issue 1 - 2022
Adjuvanticity of Aloe Vera Gel and the Role of Butyrate Fermented as an Adjuvant for COVID-19 Vaccination
Akira Yagi1* and Byun P Yu2
1Special Advisor of Japan Aloe Science Association, Professor, Emeritus of Fukuyama University, Hiroshima, Japan
2Professor Emeritus of University of Texas, Heath Science Center, Department of Physiology, San Antonio, Texas, USA
*Corresponding Author: Akira Yagi, Special Advisor of Japan Aloe Science Association; Professor Emeritus of Fukuyama University, Hiroshima, Japan.
Received: December 08, 2021; Published: December 30, 2021




Abstract

Adjuvants are added to vaccinations to boost their immunogenicity. We reviewed what we know about how butyrate affects immunity and adjuvant action. The usefulness of Aloe vera, aloe vera gel polysaccharide (acemannan), and butyrate fermented adjuvants in increasing Covid-19 immunization efficacy was thoroughly investigated. Butyrate, a known histone deacetylase inhibitor that stimulates expression of numerous genes involved in immune system pathways, was studied extensively for its adjuvanticity and effects on virus infection.

Keywords: Adjuvanticity; Aloe Vera Gel; Butyrate Fermented; Covid-19 Va

References

  1. A Yagi. “Aloe vera high molecular weight fractions as carbohydrate-based immune adjuvants”. Journal of Gastroenterology and Hepatology Research 2013; 2.5 (2013): 568-570.
  2. Aguilar JC., et al. “Intranasal immunization using HBsAG-acemannan formulations: kinetics and duration of serum IgG responses”. Biotechnologia Aplicada 17 (2000): 120.
  3. Alonso M., et al. “On the isolation of immunostimulatory active acemannan from Aloe barbadensis”. Biotechnogia Aplicada2 (2012): 87-101.
  4. Abdy E., et al. “Comparative effects of Aloe vera gel and Freund’s adjuvant in vaccination of common carp (Cyprinus carpio L.) against”. Aeromonas hydrophila Aquuaculture Int 25 (2017): 727-742.
  5. Song EJ., et al. “Adjuvanticity of processed aloe vera gel for influenza vaccination in mice”. Immune Network 4 (2020): e31.
  6. Yakabe K., et al. “Understanding host immunity and the gut microbiota inspires the new development of vaccines and adjuvants”. Pharmaceutics 13 (2021): 163.
  7. Lu W., et al. “The potential role of probiotics in protection against influenza A virus infection in mice”. Foods 10 (2021): 902.
  8. Chen J and Vitetta L. “Modulation of gut microbiota for prevention and treatment of COVID-19”. Journal of Clinical Medicine 10 (2021): 2903.
  9. Chen J., et al. “Altered gut microbial metabolite could mediate the effects of risk factors in COVID-19”. Reviews in Medical Virology 5 (2021): 1-13.
  10. Chen J and Vitetta L. “The role of butyrate in attenuating pathobiont-induced hyperinflammation”. Immune Network2 (2020): e15.
  11. Chen J., et al. “The intestinal microbiota and improving the efficacy of COVID-19 vaccinations”. Journal of Functional Foods 87 (2021): 104850.
  12. Yagi A., et al. “Prophylactic role of Aloe components, butyrate fermented, micrnas, and hyaluronan on Alzheimer’s disease, Parkinson’s disease, and osteoarthritis in knee joints: Case reports of aloe vera juice ingestion producing intestinal butyrogenic microbiome and bone regeneration”. Journal of Gastroenterology and Hepatology Research 1 3392-3406.
  13. He X., et al.Faealibacterium prausnitzii: A next-generation probiotic in gut disease improvement”. Canadian Journal of Infectious Diseases and Medical Microbiology (2021).
  14. Yeoh YK., et al. “Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19”. Gutmicrobiota 70 (2021): 698-706.
  15. Walton GE., et al. “Mechanisms linking the human gut microbiome to prophylactic and treatment strategies for COVID-19”. British Journal of Nutrition2 (2020): 219-227.
  16. Lau HCH., et al. “Targeting the gut microbiota in COVID-19: Hype or Hope?” Gastroenterology (2021): 1-8.
  17. Archer DL and Kramer DC. “The use of microbial accessible and fermentable carbohydrates and/or butyrate as supportive treatment for patients with Coronavirus SARS-CoV-2 infection”. Frontiers in Medicine 7 (2020): 292.
  18. Sehli S., et al. “Metagenomics approaches to investigate the gut microbiome of COVID-19 patients”. Bioinformatics and Biology Insights 15 (2021): 1-8.
  19. Belkaid Y and Hand T. “Role of the microbiota in immunity and inflammation”. Cell 159 (2014): 121-141.
  20. Belkaid Y and Harrison OJ. “Homeostasis immunity and microbiota”. Immunity4 (2017): 562-567.
  21. Shenoy S. “Gut microbiome, vitamin D, ACE2 interaction are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection”. Inflammation Research 5 (2021): 1-4.
  22. Kabbash A., et al. “Exploratory approaches for the use of Aloe for Covid-19 treatment: Prevention and mitigation effect”. Journal of Diabetes Research Reviews and Reports 4 (2020): 1-6.
  23. Yagi A., et al. “Putative roles of Aloe ingredients in aging and age-related diseases: Management of microbiota senoinflammatory process”. Journal of Gastroenterology and Hepatology Research2 (2021): 3460-3465.
  24. Li RW and Li CJ. “Butyrate induces profound changes in gene expression related to multiple signaling pathways in bovine kidney epithelial cells”. BMC Genomics 73 (2006): 234.
  25. Li J., et al. “Butyrate regulates COVID-19-relevant genes in gut epithelial organoids from normotensive rats”. Hypertension2 (2021): 213-e216.
  26. Chemudupati M., et al. “Butyrate reprograms expression of specific interferon-stimulated genes”. Journal of Virology16 (2020): e00326-420.
Citation: Akira Yagi and Byun P Yu. “Adjuvanticity of Aloe Vera Gel and the Role of Butyrate Fermented as an Adjuvant for COVID-19 Vaccination”. EC Clinical and Medical Case Reports 5.1 (2022): 21-26.

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